POSTN and SPART

		POSTN	SPART
Description		periostin	spartin
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Golgi Apparatus Trans-Golgi Network Extracellular Matrix Neuromuscular Junction	Cytoplasm Mitochondrial Outer Membrane Lipid Droplet Cytosol Plasma Membrane Midbody Synapse
	Molecular Function	Extracellular Matrix Structural Constituent Protein Binding Heparin Binding Metal Ion Binding Cell Adhesion Molecule Binding	Protein Binding Lipid Binding Ubiquitin Protein Ligase Binding
	Biological Process	Response To Hypoxia Negative Regulation Of Cell-matrix Adhesion Regulation Of Systemic Arterial Blood Pressure Cell Adhesion Regulation Of Notch Signaling Pathway Response To Mechanical Stimulus Tissue Development Response To Muscle Activity Positive Regulation Of Smooth Muscle Cell Migration Extracellular Matrix Organization Response To Estradiol Cellular Response To Fibroblast Growth Factor Stimulus Cellular Response To Vitamin K Cellular Response To Tumor Necrosis Factor Cellular Response To Transforming Growth Factor Beta Stimulus Negative Regulation Of Substrate Adhesion-dependent Cell Spreading Neuron Projection Extension Bone Regeneration Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production	Lipid Metabolic Process Lipid Transport Lipid Catabolic Process BMP Signaling Pathway Negative Regulation Of BMP Signaling Pathway Lipid Droplet Organization Collateral Sprouting In Absence Of Injury Negative Regulation Of Collateral Sprouting In Absence Of Injury Neuromuscular Process Cell Division Regulation Of Mitochondrial Membrane Potential Adipose Tissue Development Lipophagy Midbody Abscission Regulation Of Biological Quality
Pathways
Drugs
Diseases			Hereditary spastic paraplegia (SPG)
GWAS		Age-related macular degeneration ( 23326517) Blood protein levels ( 30072576) Plasma proprotein convertase subtilisin/kexin type 9 levels in stable coronary artery disease ( 29748315) Tourette's syndrome or obsessive-compulsive disorder ( 25158072)
Interacting Genes			21 interacting genes: APP APPL1 DESI2 EPN2 EPS15 GPR35 ITCH MAP3K1 OTUB2 OTUD7B OTULIN PLIN3 PRKAR1A RABGEF1 SMURF2 TUBA1A UBAC1 USP5 WWP2 YOD1 ZFYVE9
Entrez ID		10631	23111
HPRD ID		12295	06170
Ensembl ID		ENSG00000133110	ENSG00000133104
Uniprot IDs		Q15063	A0A024RDV9 Q8N0X7
PDB IDs		5WT7 5YJG 5YJH	2DL1 4U7I
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Collateral Sprouting In Absence Of Injury Dolichyl-phosphate Beta-glucosyltransferase Activity Collateral Sprouting In Absence Of Injury Lipophagy Cytoplasmic Side Of Rough Endoplasmic Reticulum Membrane Negative Regulation Of Collateral Sprouting Regulation Of Collateral Sprouting Collateral Sprouting Midbody Abscission Protein N-linked Glycosylation Via Asparagine Dolichol-linked Oligosaccharide Biosynthetic Process Mitotic Cytokinetic Process Cytokinetic Process Lipid Droplet Organization	Cysteine-type Deubiquitinase Activity Protein K48-linked Deubiquitination Early Endosome Membrane Protein Deubiquitination Protein Modification By Small Protein Removal Protein K11-linked Deubiquitination Post-translational Protein Modification Cysteine-type Peptidase Activity Cytosol K48-linked Deubiquitinase Activity Endosome Early Endosome Deubiquitinase Activity Protein K63-linked Deubiquitination Proteolysis Protein Modification Process Cytoplasm Endocytosis Peptidase Activity Negative Regulation Of Signal Transduction Negative Regulation Of Signaling Negative Regulation Of Cell Communication Protein Metabolic Process Cell Surface Receptor Signaling Pathway Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Regulation Of Protein Localization Import Into Cell Protein Ubiquitination Response To Mechanical Stimulus Negative Regulation Of Leukocyte Activation Regulation Of Immune Response Neuromuscular Junction Negative Regulation Of Protein Localization Negative Regulation Of Transport Negative Regulation Of Cell Activation Protein Modification By Small Protein Conjugation K63-linked Deubiquitinase Activity Regulation Of Notch Signaling Pathway Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Ubiquitin Binding Regulation Of Signaling Ubiquitin Ligase Complex Negative Regulation Of Multicellular Organismal Process Regulation Of Cytokine Production Vesicle-mediated Transport Symbiont Entry Into Host Cell Negative Regulation Of Immune System Process Regulation Of Immune System Process Negative Regulation Of Transporter Activity Regulation Of Signal Transduction
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