IFITM2 and UPF3A

Number of citations of the paper that reports this interaction (PubMedID 15231747)
47

Data Source:
HPRD (two hybrid)

		IFITM2	UPF3A
Description		interferon induced transmembrane protein 2	UPF3A regulator of nonsense mediated mRNA decay
Image		No pdb structure
GO Annotations	Cellular Component	Lysosome Lysosomal Membrane Endosome Plasma Membrane Membrane Late Endosome Membrane Protein-containing Complex	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Plasma Membrane Exon-exon Junction Complex Neuron Projection
	Molecular Function		Nucleic Acid Binding RNA Binding MRNA Binding Protein Binding Telomeric DNA Binding
	Biological Process	Immune System Process Immune Response Response To Virus Response To Type II Interferon Response To Interferon-alpha Response To Interferon-beta Cellular Response To Interferon-beta Negative Regulation Of Viral Genome Replication Innate Immune Response Host-mediated Suppression Of Symbiont Invasion Defense Response To Virus Type I Interferon-mediated Signaling Pathway	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay In Utero Embryonic Development Spermatogenesis Positive Regulation Of Translation MRNA Transport Positive Regulation Of MRNA Cis Splicing, Via Spliceosome Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay
Pathways		Interferon alpha/beta signaling	Regulation of expression of SLITs and ROBOs Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs
Diseases
GWAS		Autoimmune thyroid disease ( 32581359) Basophil count ( 32888494) Eosinophil count ( 27863252 32888494) Eosinophil percentage of white cells ( 32888494) Granulocyte count ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) Liver enzyme levels (alkaline phosphatase) ( 33972514) Lymphocyte percentage of white cells ( 32888494 27863252) Mean platelet volume ( 32888494) Medication use (thyroid preparations) ( 31015401) Monocyte count ( 32888494 27863252) Monocyte percentage of white cells ( 32888494 27863252) Myeloid white cell count ( 27863252) Myocardial infarction ( 33532862) Neutrophil count ( 27863252 32888494) Neutrophil percentage of white cells ( 32888494 27863252) Platelet count ( 27863252 32888494) Plateletcrit ( 32888494) Red blood cell count ( 32888494) Sum basophil neutrophil counts ( 27863252) Sum eosinophil basophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) White blood cell count ( 27863252 32888494) White blood cell count (basophil) ( 27863252)	Height ( 31562340) Hip circumference adjusted for BMI ( 34021172) Nodular sclerosis Hodgkin lymphoma ( 29196614) Pulse pressure ( 30578418)
Interacting Genes		4 interacting genes: KRTAP1-1 PTCD3 SLC10A1 UPF3A	9 interacting genes: ALYREF APP GSK3B IFITM2 NXF1 PIGT RBM8A SMG1 UPF1
Entrez ID		10581	65110
HPRD ID		05718	09274
Ensembl ID		ENSG00000185201	ENSG00000169062
Uniprot IDs		Q01629	B3KUE7 Q9H1J1
PDB IDs			2L08 7QG6
Enriched GO Terms of Interacting Partners?			MRNA Export From Nucleus RNA Export From Nucleus Nuclear Export MRNA Transport RNA Transport Nucleobase-containing Compound Transport Nuclear Transport Nucleocytoplasmic Transport Exon-exon Junction Complex Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Regulation Of Translation Cellular Localization Post-transcriptional Regulation Of Gene Expression Intracellular Transport Transcription Export Complex Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process Establishment Of Localization In Cell Telomeric DNA Binding RNA Catabolic Process Response To Cytokine Response To Peptide Negative Regulation Of Gene Expression Neuron Projection Organization Regulation Of Long-term Synaptic Potentiation Peptidyl-serine Phosphorylation MRNA Metabolic Process Negative Regulation Of Protein Localization To Nucleus MRNA Binding Cellular Response To Amyloid-beta Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Response To Amyloid-beta Positive Regulation Of Toll Signaling Pathway Regulation Of Microtubule Anchoring At Centrosome Glial Cell Development Positive Regulation Of Establishment Of Protein Localization Positive Regulation Of Neuron Apoptotic Process Regulation Of Protein Metabolic Process Protein Phosphorylation Nucleobase-containing Compound Catabolic Process RNA Binding Acetylcholine Receptor Activator Activity Response To Interleukin-1 Macromolecule Metabolic Process Lipoprotein Particle Positive Regulation Of Protein Import Phosphorylation
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