SLC35A1 and PIK3IP1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SLC35A1	PIK3IP1
Description		solute carrier family 35 member A1	phosphoinositide-3-kinase interacting protein 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Golgi Apparatus Plasma Membrane Membrane	Extracellular Space Plasma Membrane Membrane
	Molecular Function	CMP-N-acetylneuraminate Transmembrane Transporter Activity Protein Binding Pyrimidine Nucleotide-sugar Transmembrane Transporter Activity Antiporter Activity	Endopeptidase Activity Signaling Receptor Binding Protein Binding Phosphatidylinositol 3-kinase Inhibitor Activity
	Biological Process	Carbohydrate Metabolic Process N-acetylneuraminate Metabolic Process CMP-N-acetylneuraminate Biosynthetic Process CMP-N-acetylneuraminate Transmembrane Transport Protein Modification Process Pyrimidine Nucleotide-sugar Transmembrane Transport	Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Pathways		Sialic acid metabolism Defective SLC35A1 causes congenital disorder of glycosylation 2F (CDG2F) Defective SLC35A1 causes congenital disorder of glycosylation 2F (CDG2F) Transport of nucleotide sugars Matriglycan biosynthesis on DAG1
Drugs
Diseases		Congenital disorders of glycosylation (CDG) type II
GWAS		Bone mineral density (hip) ( 30172743) Obesity-related traits ( 23251661)	Fish- and plant-related diet ( 32066663) Metabolite levels ( 23823483) Oily fish consumption ( 32066663) Pork consumption ( 32066663) Red cell distribution width ( 32888494)
Interacting Genes		36 interacting genes: AQP6 ARL13B ASGR2 ASZ1 BCL2L13 CD53 CERS4 CPLX4 EBAG9 ERGIC3 F11R F2RL1 FAM209A FNDC9 FXYD3 GPX8 KIR3DL3 LHFPL5 LMNA MCFD2 MGST3 MRPS18B PIK3IP1 PLPP4 PSCA RELL2 SAR1A SDC3 SLC1A1 SLC34A2 SSMEM1 SYT2 TCTA TMEM139 TMPRSS2 TMX2	7 interacting genes: MAGEA11 MFSD11 SLC35A1 TMEM218 UBQLN1 UBQLN2 UPK1B
Entrez ID		10559	113791
HPRD ID		09290	17518
Ensembl ID		ENSG00000164414	ENSG00000100100
Uniprot IDs		P78382	Q96FE7
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane	Positive Regulation Of ERAD Pathway Regulation Of ERAD Pathway Polyubiquitin Modification-dependent Protein Binding Positive Regulation Of Response To Endoplasmic Reticulum Stress CMP-N-acetylneuraminate Transmembrane Transporter Activity CMP-N-acetylneuraminate Transmembrane Transport Autophagosome Regulation Of Response To Endoplasmic Reticulum Stress Autophagosome Assembly ERAD Pathway Negative Regulation Of Store-operated Calcium Channel Activity Autophagosome Organization Negative Regulation Of G Protein-coupled Receptor Internalization Positive Regulation Of Proteasomal Protein Catabolic Process Apical Plasma Membrane Urothelial Plaque Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Negative Regulation Of Toll-like Receptor 3 Signaling Pathway CMP-N-acetylneuraminate Metabolic Process CMP-N-acetylneuraminate Biosynthetic Process Negative Regulation Of Clathrin-dependent Endocytosis Pyrimidine Nucleotide-sugar Transmembrane Transporter Activity Vacuole Organization Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Regulation Of Macroautophagy Positive Regulation Of Protein Catabolic Process Response To Endoplasmic Reticulum Stress Pyrimidine Nucleotide-sugar Transmembrane Transport Nucleotide-sugar Transmembrane Transport N-acetylneuraminate Metabolic Process Regulation Of Toll-like Receptor 3 Signaling Pathway Aggrephagy Autophagy Negative Regulation Of Receptor Internalization Regulation Of Clathrin-dependent Endocytosis
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