SLC35A1 and SDC3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SLC35A1	SDC3
Description		solute carrier family 35 member A1	syndecan 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Golgi Apparatus Plasma Membrane Membrane	Golgi Lumen Plasma Membrane Cell Surface Membrane Extracellular Matrix Lysosomal Lumen Microspike
	Molecular Function	CMP-N-acetylneuraminate Transmembrane Transporter Activity Protein Binding Pyrimidine Nucleotide-sugar Transmembrane Transporter Activity Antiporter Activity	Protein Binding Identical Protein Binding
	Biological Process	Carbohydrate Metabolic Process N-acetylneuraminate Metabolic Process CMP-N-acetylneuraminate Biosynthetic Process CMP-N-acetylneuraminate Transmembrane Transport Protein Modification Process Pyrimidine Nucleotide-sugar Transmembrane Transport	Cell Migration
Pathways		Sialic acid metabolism Defective SLC35A1 causes congenital disorder of glycosylation 2F (CDG2F) Defective SLC35A1 causes congenital disorder of glycosylation 2F (CDG2F) Transport of nucleotide sugars Matriglycan biosynthesis on DAG1	Glycosaminoglycan-protein linkage region biosynthesis HS-GAG biosynthesis HS-GAG biosynthesis HS-GAG degradation Cell surface interactions at the vascular wall Syndecan interactions Syndecan interactions Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective EXT2 causes exostoses 2 Defective EXT1 causes exostoses 1, TRPS2 and CHDS Defective B3GALT6 causes EDSP2 and SEMDJL1 Attachment and Entry Attachment and Entry Retinoid metabolism and transport Respiratory syncytial virus (RSV) attachment and entry RSV-host interactions
Drugs
Diseases		Congenital disorders of glycosylation (CDG) type II
GWAS		Bone mineral density (hip) ( 30172743) Obesity-related traits ( 23251661)	Loneliness ( 27629369) Systolic blood pressure ( 34074324)
Interacting Genes		36 interacting genes: AQP6 ARL13B ASGR2 ASZ1 BCL2L13 CD53 CERS4 CPLX4 EBAG9 ERGIC3 F11R F2RL1 FAM209A FNDC9 FXYD3 GPX8 KIR3DL3 LHFPL5 LMNA MCFD2 MGST3 MRPS18B PIK3IP1 PLPP4 PSCA RELL2 SAR1A SDC3 SLC1A1 SLC34A2 SSMEM1 SYT2 TCTA TMEM139 TMPRSS2 TMX2	32 interacting genes: AGR2 CASK CMTM7 COL5A1 CSK CTTN CUX1 EPHB4 FGF2 FYN ITGB4 KCNJ2 KRTAP1-1 KRTAP1-3 KRTAP10-3 KRTAP2-3 KRTAP2-4 KRTAP4-2 KRTAP5-7 KRTAP5-9 KRTAP9-2 LCE3D MDK PLN PTN SLC35A1 SMIM1 TMEM14C TMEM218 TUBA1A TUBB TUBB2A
Entrez ID		10559	9672
HPRD ID		09290	01719
Ensembl ID		ENSG00000164414	ENSG00000162512
Uniprot IDs		P78382	O75056
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane	Intermediate Filament Keratin Filament Response To Mechanical Stimulus Cell Motility Cell Migration Positive Regulation Of Blood Vessel Branching Regulation Of Blood Vessel Branching Regulation Of Calcium Ion Import Leukocyte Chemotaxis Involved In Inflammatory Response Integrin Binding Cell Projection Morphogenesis Positive Regulation Of Chemotaxis Learning Or Memory Chondroitin Sulfate Binding Positive Regulation Of Hepatocyte Proliferation Dendritic Spine Maintenance Estrous Cycle Heparin Binding Anatomical Structure Morphogenesis Learning Relaxation Of Cardiac Muscle Cognition Regulation Of Response To Wounding Regulation Of Hepatocyte Proliferation Basement Membrane Proline-rich Region Binding Regulation Of Chemotaxis Positive Regulation Of Cell Division Regulation Of Neural Precursor Cell Proliferation Positive Regulation Of Vascular Endothelial Cell Proliferation Response To L-glutamate Relaxation Of Muscle Positive Regulation Of Oligodendrocyte Differentiation Cerebral Cortex Development Response To Auditory Stimulus Ovulation Cycle Leukocyte Migration Involved In Inflammatory Response Neuron Projection Arborization Positive Regulation Of Neurogenesis Positive Regulation Of Stem Cell Differentiation Schaffer Collateral - CA1 Synapse Structural Constituent Of Cytoskeleton Identical Protein Binding Cell Migration Involved In Sprouting Angiogenesis Glial Cell Differentiation Calcium Ion Transport Dentate Gyrus Development Integrin Biosynthetic Process Developmental Process Protein Tyrosine Kinase Activity
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