TRIM38 and TSBP1

		TRIM38	TSBP1
Description		tripartite motif containing 38	testis expressed basic protein 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol	Nucleus Membrane
	Molecular Function	Transcription Coactivator Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Immune System Process Regulation Of Gene Expression Protein Ubiquitination Protein Sumoylation Regulation Of Interferon-beta Production Positive Regulation Of Canonical NF-kappaB Signal Transduction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Viral Genome Replication Innate Immune Response Positive Regulation Of DNA-templated Transcription Regulation Of Viral Entry Into Host Cell Positive Regulation Of Viral Entry Into Host Cell Positive Regulation Of Viral Process Negative Regulation Of Defense Response To Virus Protein K48-linked Ubiquitination Regulation Of Viral Life Cycle
Pathways		Interferon gamma signaling
Drugs
Diseases
GWAS		A body shape index ( 34021172) Autism spectrum disorder or schizophrenia ( 28540026) Brain morphology (MOSTest) ( 32665545) Cardiac hypertrophy ( 21348951) Fish- and plant-related diet ( 32066663) Height ( 28552196) Iron status biomarkers ( 19084217) Lung cancer ( 28604730) Lung cancer in ever smokers ( 28604730) Refractive error ( 32231278) Subcortical volume (MOSTest) ( 32665545)	Type 1 diabetes (age at diagnosis) ( 33179336)
Interacting Genes		30 interacting genes: ATXN1 BYSL EIF1B GMCL1 GORASP2 HSPA1A HSPA1B HSPA1L HSPA2 HSPA8 MTURN PIAS4 PSMA4 RFC5 RIPK1 RNF4 SDCBP STXBP1 TCEA2 TSPYL4 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2I UBE2U ZNF764	1 interacting genes: FBXO7
Entrez ID		10475	10665
HPRD ID		15555	09851
Ensembl ID		ENSG00000112343	ENSG00000204296
Uniprot IDs		O00635	A0A1U9X7D1 B4DXY0 E9PLW3 Q13647 Q5SRN2
PDB IDs
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Protein K48-linked Ubiquitination ATP Binding Protein Refolding Protein Polyubiquitination ATP-dependent Protein Folding Chaperone Protein K11-linked Ubiquitination Ubiquitin-protein Transferase Activity Nucleotide Binding Macromolecule Catabolic Process Protein Modification By Small Protein Conjugation C3HC4-type RING Finger Domain Binding Protein Folding Chaperone Blood Microparticle ATP-dependent Protein Disaggregase Activity Heat Shock Protein Binding Post-translational Protein Modification Response To Unfolded Protein Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Negative Regulation Of Inclusion Body Assembly Protein Ubiquitination Unfolded Protein Binding Nucleus Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Protein Monoubiquitination Proteolysis Involved In Protein Catabolic Process Protein Modification Process Nucleoplasm Regulation Of Inclusion Body Assembly Macromolecule Metabolic Process Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Transferase Activity Protein K63-linked Ubiquitination Protein K6-linked Ubiquitination Cellular Response To Steroid Hormone Stimulus ISG15 Transferase Activity Ubiquitin Protein Ligase Binding Cellular Response To Stress Regulation Of Spindle Assembly Catabolic Process Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Protein Metabolic Process Protein Folding Positive Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Cellular Heat Acclimation Negative Regulation Of Protein Localization To Chromatin ISG15-protein Conjugation Positive Regulation Of Myeloid Cell Differentiation ATP Hydrolysis Activity	Protein K48-linked Ubiquitination Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Protein Polyubiquitination Lewy Body Core Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Protein Catabolic Process Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Positive Regulation Of Viral Entry Into Host Cell Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Defense Response To Virus Post-translational Protein Modification Regulation Of Viral Entry Into Host Cell Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Mitophagy Positive Regulation Of Viral Life Cycle Positive Regulation Of Viral Genome Replication Positive Regulation Of Autophagy Of Mitochondrion Protein Targeting To Mitochondrion Macromolecule Catabolic Process Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Proteolysis Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Mitophagy Protein Sumoylation Regulation Of Autophagy Of Mitochondrion Positive Regulation Of Viral Process Regulation Of Interferon-beta Production Negative Regulation Of Lymphocyte Differentiation SCF Ubiquitin Ligase Complex Regulation Of Defense Response To Virus Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle G1/S Phase Transition Protein Modification Process Regulation Of Viral Genome Replication Establishment Of Protein Localization To Mitochondrion Autophagy Of Mitochondrion Regulation Of Viral Life Cycle Immune System Process Catabolic Process Ubiquitin-like Ligase-substrate Adaptor Activity Ubiquitin Ligase Complex Positive Regulation Of Macroautophagy
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