SLC1A6 and ARHGEF11

Number of citations of the paper that reports this interaction (PMID 11242047)
40

Data Source:
HPRD (in vivo, in vitro)

		SLC1A6	ARHGEF11
Gene Name		solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6	Rho guanine nucleotide exchange factor (GEF) 11
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Membrane	Intracellular Cytoplasm Cytosol Membrane
	Molecular Function	L-glutamate Transmembrane Transporter Activity L-aspartate Transmembrane Transporter Activity Sodium:dicarboxylate Symporter Activity	G-protein Coupled Receptor Binding Rho Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding
	Biological Process	Ion Transport Synaptic Transmission Aspartate Transport L-glutamate Transport Regulation Of Membrane Potential Transmembrane Transport L-glutamate Transmembrane Transport L-aspartate Transmembrane Transport	Cytokinesis Regulation Of Cell Growth Movement Of Cell Or Subcellular Component Striated Muscle Contraction G-protein Coupled Receptor Signaling Pathway Small GTPase Mediated Signal Transduction Rho Protein Signal Transduction Axon Guidance Establishment Of Cell Polarity Actin Cytoskeleton Organization Positive Regulation Of Rho GTPase Activity Termination Of G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Apoptotic Process Positive Regulation Of Transcription, DNA-templated Neurotrophin TRK Receptor Signaling Pathway Regulation Of Small GTPase Mediated Signal Transduction Apoptotic Signaling Pathway
Pathways		Neurotransmitter Release Cycle Transport of inorganic cations/anions and amino acids/oligopeptides SLC-mediated transmembrane transport Glutamate Neurotransmitter Release Cycle Transmission across Chemical Synapses	Signaling by GPCR Signalling by NGF Axon guidance Semaphorin interactions Cell death signalling via NRAGE, NRIF and NADE p75 NTR receptor-mediated signalling Rho GTPase cycle GPCR downstream signaling NRAGE signals death through JNK Signaling by Rho GTPases G alpha (12/13) signalling events Sema4D in semaphorin signaling Sema4D induced cell migration and growth-cone collapse
Drugs
Diseases
GWAS
Protein-Protein Interactions		2 interactors: ARHGEF11 ARIH2	13 interactors: ABCA1 CDC42 GNA12 GNA13 LPAR1 LPAR2 MAP1A MAP1B PLXNB1 PLXNB2 PLXNB3 RHOA SLC1A6
Entrez ID		6511	9826
HPRD ID		09005	09302
Ensembl ID		ENSG00000105143	ENSG00000132694
Uniprot IDs		B7Z7Q5 P48664 Q8N753	F8W8P9 O15085
PDB IDs			1HTJ 1XCG 2DLS 3KZ1 3T06
Enriched GO Terms of Interacting Partners?			Regulation Of Cell Morphogenesis Regulation Of Cell Projection Organization Positive Regulation Of Cell Projection Organization Positive Regulation Of Cell Morphogenesis Involved In Differentiation Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Axonogenesis Positive Regulation Of Neuron Projection Development Regulation Of Cellular Component Organization Positive Regulation Of Cell Development Cell Surface Receptor Signaling Pathway Regulation Of Cell Migration Regulation Of Cell Motility Positive Regulation Of Neuron Differentiation Regulation Of Rho Protein Signal Transduction Regulation Of Locomotion Regulation Of Intracellular Signal Transduction Regulation Of Cellular Component Movement Regulation Of Neuron Projection Development Regulation Of Axonogenesis Regulation Of Cell Shape Semaphorin-plexin Signaling Pathway Positive Regulation Of Neurogenesis Regulation Of Cell Development Positive Regulation Of Cell Differentiation Apolipoprotein A-I-mediated Signaling Pathway Rho Protein Signal Transduction Axonogenesis Generation Of Neurons Signaling Regulation Of Cell Differentiation Regulation Of Neuron Differentiation Cell Communication Axon Development Positive Regulation Of Phospholipase Activity Anatomical Structure Morphogenesis Neurogenesis Cell Morphogenesis Involved In Neuron Differentiation Cell Differentiation Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity Neuron Projection Morphogenesis Cell Projection Organization Regulation Of Ras Protein Signal Transduction Regulation Of Neurogenesis Regulation Of Signal Transduction Cell Morphogenesis Involved In Differentiation Ossification Involved In Bone Maturation Signal Transduction Positive Regulation Of Intracellular Signal Transduction Bone Maturation
Tagcloud ?		1rn antidopaminergic daao darpp dgcr2 dgcr6 drd2 drd3 dtnbp1 evolves facets forcefully g72 gabra1 gabra6 gabrp gria1 grin1 grm3 merge mglu2 networking prodh rgs4 underpinned unifying vulnerablility zdhhc8
Tagcloud (Difference) ?		1rn antidopaminergic daao darpp dgcr2 dgcr6 drd2 drd3 dtnbp1 evolves facets forcefully g72 gabra1 gabra6 gabrp gria1 grin1 grm3 merge mglu2 networking prodh rgs4 underpinned unifying vulnerablility zdhhc8
Tagcloud (Intersection) ?