SLC1A6 and ARHGEF11

Number of citations of the paper that reports this interaction (PubMedID 11242047)
0

Data Source:
HPRD (in vitro, in vivo)

		SLC1A6	ARHGEF11
Description		solute carrier family 1 member 6	Rho guanine nucleotide exchange factor 11
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Apparatus Plasma Membrane Membrane Presynaptic Membrane Intermediate Filament Cytoskeleton Membrane Protein Complex Glutamatergic Synapse	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Membrane
	Molecular Function	L-glutamate Transmembrane Transporter Activity High-affinity L-glutamate Transmembrane Transporter Activity Neutral L-amino Acid Transmembrane Transporter Activity L-aspartate Transmembrane Transporter Activity Symporter Activity Glutamate:sodium Symporter Activity Metal Ion Binding	G Protein-coupled Receptor Binding Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding
	Biological Process	Neurotransmitter Uptake Monoatomic Ion Transport Neurotransmitter Transport Amino Acid Transport Chemical Synaptic Transmission Neutral Amino Acid Transport Aspartate Transmembrane Transport L-glutamate Transmembrane Transport Regulation Of Membrane Potential Establishment Of Localization In Cell Import Into Cell L-glutamate Import Across Plasma Membrane L-aspartate Import Across Plasma Membrane	Regulation Of Cell Growth Striated Muscle Contraction G Protein-coupled Receptor Signaling Pathway Rho Protein Signal Transduction Establishment Of Cell Polarity Actin Cytoskeleton Organization Positive Regulation Of DNA-templated Transcription Regulation Of Small GTPase Mediated Signal Transduction
Pathways		Glutamate Neurotransmitter Release Cycle SLC-mediated transport of amino acids	NRAGE signals death through JNK G alpha (12/13) signalling events Sema4D induced cell migration and growth-cone collapse RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle
Drugs		Glutamic acid
Diseases
GWAS		Familial squamous cell lung carcinoma ( 29924316)	Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Chin dimples ( 27182965) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Heel bone mineral density ( 30598549) Height ( 31562340) Lymphocyte count ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte percentage of white cells ( 32888494) Platelet count ( 32888494) Plateletcrit ( 32888494) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		2 interacting genes: ARHGEF11 ARIH2	16 interacting genes: ABCA1 CDC42 GNA12 GNA13 KLHL20 LPAR1 LPAR2 MAP1A MAP1B PLXNB1 PLXNB2 PLXNB3 PTPRF RHOA RPS6KA1 SLC1A6
Entrez ID		6511	9826
HPRD ID		09005	09302
Ensembl ID		ENSG00000105143	ENSG00000132694
Uniprot IDs		B7Z7Q5 P48664	A0AAQ5BIK5 O15085
PDB IDs			1HTJ 1XCG 2DLS 3KZ1 3T06 5E6P 5JHG 5JHH 5TYT
Enriched GO Terms of Interacting Partners?			Regulation Of Cell Shape Regulation Of Cellular Component Organization Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Semaphorin-plexin Signaling Pathway Regulation Of Neuron Projection Development Regulation Of Cell Morphogenesis Cell Junction Assembly Semaphorin Receptor Activity Semaphorin Receptor Complex Positive Regulation Of Cellular Component Organization Regulation Of Biological Quality G Protein Activity Glutamatergic Synapse Neuronal Cell Body Positive Regulation Of Cell Projection Organization D5 Dopamine Receptor Binding Positive Regulation Of Axonogenesis Regulation Of Rho Protein Signal Transduction Establishment Of Monopolar Cell Polarity Establishment Or Maintenance Of Monopolar Cell Polarity Regulation Of Cell Migration Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Plasma Membrane Regulation Of Developmental Process Regulation Of Cell Motility Positive Regulation Of Rho Protein Signal Transduction Synapse Assembly Regulation Of Locomotion Cell Junction Organization Lysophosphatidic Acid Receptor Activity Regulation Of Cytoskeleton Organization Apolipoprotein A-I-mediated Signaling Pathway Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Anatomical Structure Morphogenesis Regulation Of Axonogenesis Membrane Invagination Cell Migration Rho-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Supramolecular Fiber Organization Regulation Of Supramolecular Fiber Organization Positive Regulation Of Cytoskeleton Organization Positive Regulation Of Actin Filament Bundle Assembly Ossification Involved In Bone Maturation Rho Protein Signal Transduction Cell Motility Regulation Of Intracellular Signal Transduction Endocytic Vesicle
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