ABCA7 and C5AR2

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		ABCA7	C5AR2
Description		ATP binding cassette subfamily A member 7	complement C5a receptor 2
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Phagocytic Cup Cytoplasm Endosome Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Cell Surface Membrane Cell Junction Early Endosome Membrane Ruffle Membrane Cell Projection Intracellular Membrane-bounded Organelle Glial Cell Projection	Plasma Membrane Basal Plasma Membrane Membrane Apical Part Of Cell
	Molecular Function	Nucleotide Binding ATP Binding Phospholipid Transporter Activity ATP Hydrolysis Activity Apolipoprotein A-I Receptor Activity ATPase-coupled Transmembrane Transporter Activity Phosphatidylcholine Floppase Activity Phosphatidylserine Floppase Activity ATPase-coupled Intramembrane Lipid Transporter Activity Floppase Activity ABC-type Transporter Activity	Complement Receptor Activity Complement Component C5a Receptor Activity G Protein-coupled Receptor Activity Protein Binding
	Biological Process	Lipid Transport Phagocytosis Memory Visual Learning Positive Regulation Of Cholesterol Efflux Regulation Of Lipid Metabolic Process Cholesterol Efflux Phospholipid Efflux Amyloid-beta Formation High-density Lipoprotein Particle Assembly Protein Localization To Nucleus Apolipoprotein A-I-mediated Signaling Pathway Negative Regulation Of Amyloid Precursor Protein Biosynthetic Process Negative Regulation Of MAPK Cascade Plasma Membrane Raft Organization Phospholipid Translocation Negative Regulation Of Endocytosis Positive Regulation Of Phagocytosis Transmembrane Transport Positive Regulation Of ERK1 And ERK2 Cascade Amyloid-beta Clearance By Cellular Catabolic Process Positive Regulation Of Amyloid-beta Clearance Positive Regulation Of Engulfment Of Apoptotic Cell Negative Regulation Of Amyloid-beta Formation Regulation Of Amyloid Precursor Protein Catabolic Process Positive Regulation Of Phospholipid Efflux Negative Regulation Of PERK-mediated Unfolded Protein Response Positive Regulation Of Protein Localization To Cell Surface	Complement Receptor Mediated Signaling Pathway Regulation Of Immune System Process Chemotaxis Inflammatory Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Interleukin-8 Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Complement Component C5a Signaling Pathway Negative Regulation Of Neutrophil Chemotaxis
Pathways		ABC transporters in lipid homeostasis	Peptide ligand-binding receptors Regulation of Complement cascade
Drugs
Diseases
GWAS		Alzheimer's disease ( 21460840 33074286 31473137) Alzheimer's disease (late onset) ( 21460841 30617256 23571587 24162737) Alzheimer's disease or family history of Alzheimer's disease ( 33589840 30617256) Eosinophil percentage of white cells ( 27863252) Family history of Alzheimer's disease ( 30617256) Lymphocyte percentage of white cells ( 27863252) Mean corpuscular hemoglobin concentration ( 32888494 27863252 29403010) Mean corpuscular volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 31628463) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252) Neutrophil percentage of white cells ( 27863252) Red blood cell count ( 32888494) Red cell distribution width ( 32888494) Serum metabolite levels ( 33031748) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252)
Interacting Genes		2 interacting genes: ADRB2 C5AR2	17 interacting genes: ABCA7 ACO2 ARLN C3 C4A C5AR1 CALM3 HAGHL HERC2 HERPUD1 PLXDC1 SCN1B SCRIB SLC25A11 SLC26A11 SYNGR2 TMEM234
Entrez ID		10347	27202
HPRD ID		09255	17072
Ensembl ID		ENSG00000064687	ENSG00000134830
Uniprot IDs		B3KUJ3 Q8IZY2	Q9P296
PDB IDs		8EDW 8EE6 8EEB 8EOP 8Y1O 8Y1P
Enriched GO Terms of Interacting Partners?		Mitotic Spindle Regulation Of Systemic Arterial Blood Pressure By Norepinephrine-epinephrine Intercellular Bridge Positive Regulation Of Mini Excitatory Postsynaptic Potential Response To Psychosocial Stress Norepinephrine-epinephrine-mediated Vasodilation Involved In Regulation Of Systemic Arterial Blood Pressure Beta-adrenergic Receptor Activity Norepinephrine Binding Positive Regulation Of Lipophagy Microtubule Cytoskeleton AMPA Selective Glutamate Receptor Signaling Pathway Beta2-adrenergic Receptor Activity Internode Region Of Axon Complement Component C5a Receptor Activity Complement Component C5a Signaling Pathway Negative Regulation Of Neutrophil Chemotaxis Negative Regulation Of Neutrophil Migration Positive Regulation Of Autophagosome Maturation Heat Generation G Protein-coupled Receptor Activity Complement Receptor Activity Adrenergic Receptor Activity Diet Induced Thermogenesis Adenylate Cyclase Binding Negative Regulation Of Smooth Muscle Contraction Negative Regulation Of Multicellular Organism Growth Negative Regulation Of Microtubule Polymerization Complement Receptor Mediated Signaling Pathway Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Regulation Of Autophagosome Maturation Positive Regulation Of CAMP/PKA Signal Transduction Cilium Negative Regulation Of Muscle Contraction Neuronal Dense Core Vesicle Adrenergic Receptor Signaling Pathway Negative Regulation Of Systemic Arterial Blood Pressure Negative Regulation Of Leukocyte Chemotaxis Adaptive Thermogenesis Bone Resorption Regulation Of Systemic Arterial Blood Pressure Mediated By A Chemical Signal Brown Fat Cell Differentiation Ionotropic Glutamate Receptor Signaling Pathway Myelin Sheath Positive Regulation Of Excitatory Postsynaptic Potential Regulation Of Neutrophil Chemotaxis G Protein-coupled Receptor Signaling Pathway Temperature Homeostasis Positive Regulation Of Protein-containing Complex Disassembly Regulation Of CAMP/PKA Signal Transduction Potassium Channel Regulator Activity	Positive Regulation Of Apoptotic Cell Clearance Regulation Of Apoptotic Cell Clearance Classical-complement-pathway C3/C5 Convertase Complex Amyloid-beta Clearance Regulation Of Endocytosis Positive Regulation Of Phagocytosis Complement Activation, Lectin Pathway Complement Activation, GZMK Pathway Activation Of Membrane Attack Complex Positive Regulation Of Phagocytosis, Engulfment Complement Receptor Mediated Signaling Pathway Opsonization Regulation Of Phagocytosis Regulation Of Vesicle-mediated Transport Symbiont Cell Surface Transmembrane Transporter Binding Locomotion Positive Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of Endocytosis Antigen Binding Complement Activation, Classical Pathway Regulation Of Vascular Endothelial Growth Factor Production C5L2 Anaphylatoxin Chemotactic Receptor Binding Endopeptidase Inhibitor Activity Plasma Membrane Presynaptic Endocytosis Corticospinal Neuron Axon Guidance Oxoglutarate:malate Antiporter Activity Negative Regulation Of Response To Endoplasmic Reticulum Stress Complement Activation Positive Regulation Of Activation Of Membrane Attack Complex Basolateral Plasma Membrane Negative Regulation Of High Voltage-gated Calcium Channel Activity Neural Nucleus Development Positive Regulation Of Voltage-gated Sodium Channel Activity Apolipoprotein A-I Receptor Activity Positive Regulation Of Engulfment Of Apoptotic Cell Regulation Of Engulfment Of Apoptotic Cell Scrib-APC-beta-catenin Complex
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