STAG1 and STAG2

Number of citations of the paper that reports this interaction (PubMedID 11076961)
58

Data Source:
HPRD (in vitro, in vivo)

		STAG1	STAG2
Description		STAG1 cohesin complex component	STAG2 cohesin complex component
Image
GO Annotations	Cellular Component	Chromosome, Centromeric Region Chromatin Nucleus Nucleoplasm Chromosome Cytosol Cilium Cohesin Complex Nuclear Matrix Nuclear Body Mitotic Cohesin Complex Mitotic Spindle Pole	Chromosome, Centromeric Region Chromatin Fibrillar Center Nucleus Nucleoplasm Chromosome Nucleolus Cytosol Cohesin Complex Membrane Nuclear Matrix Mitotic Cohesin Complex Mitotic Spindle Pole
	Molecular Function	Chromatin Binding Protein Binding	Chromatin Binding Protein Binding
	Biological Process	Chromosome Segregation Sister Chromatid Cohesion Establishment Of Mitotic Sister Chromatid Cohesion Cell Division Mitotic Spindle Assembly	Chromosome Segregation Sister Chromatid Cohesion Establishment Of Mitotic Sister Chromatid Cohesion Cell Division Meiotic Cell Cycle Mitotic Spindle Assembly
Pathways		Meiotic synapsis Separation of Sister Chromatids Establishment of Sister Chromatid Cohesion Cohesin Loading onto Chromatin Resolution of Sister Chromatid Cohesion SUMOylation of DNA damage response and repair proteins Estrogen-dependent gene expression	Meiotic synapsis Separation of Sister Chromatids Establishment of Sister Chromatid Cohesion Cohesin Loading onto Chromatin Resolution of Sister Chromatid Cohesion SUMOylation of DNA damage response and repair proteins Estrogen-dependent gene expression
Drugs
Diseases
GWAS		A body shape index ( 34021172) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Apolipoprotein B levels ( 32203549) Autism spectrum disorder or schizophrenia ( 28540026) Body mass index ( 25673413 28892062) C-reactive protein levels or HDL-cholesterol levels (pleiotropy) ( 27286809) Central corneal thickness ( 32528159 29760442 31798171) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Coronary artery disease ( 29212778) Dentures ( 31235808) General risk tolerance (MTAG) ( 30643258) HDL cholesterol ( 30275531) Height ( 25282103) Intraocular pressure ( 29617998) LDL cholesterol levels ( 32203549) Liver enzyme levels (alanine transaminase) ( 33972514) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Low density lipoprotein cholesterol levels ( 32154731) Multisite chronic pain ( 31194737 33830993) Myocardial infarction ( 33532862) Number of decayed, missing and filled tooth surfaces or use of dentures ( 31235808) Plateletcrit ( 32888494) Schizophrenia ( 30285260 29483656 28991256 25056061) Waist circumference adjusted for body mass index ( 34021172)	Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494)
Interacting Genes		7 interacting genes: CALM1 DSCAM RAD21 SMAD2 SMAD9 STAG2 WFDC5	7 interacting genes: ITGB1BP2 PLK1 PTEN RAD21 SSU72 STAG1 SUMO2
Entrez ID		10274	10735
HPRD ID		05076	05077
Ensembl ID		ENSG00000118007	ENSG00000101972
Uniprot IDs		Q8WVM7	Q8N3U4
PDB IDs		5QSM 5QSN 5QSO 5QSP 5QSQ 5QSR 5QSS 5QST 5QSU 5QSV 5QSW 5QSX 5QSY 5QSZ 6QB5 6R7O 6RRC 6RRK 6WG3 7W1M	4PJU 4PJW 4PK7 6QNX 7ZJS 8K4D
Enriched GO Terms of Interacting Partners?		Cohesin Complex Meiotic Cohesin Complex Sister Chromatid Cohesion Heteromeric SMAD Protein Complex SMAD Protein Complex Establishment Of Sister Chromatid Cohesion Establishment Of Mitotic Sister Chromatid Cohesion Mitotic Cohesin Complex Regulation Of Cell Communication By Electrical Coupling Detection Of Calcium Ion I-SMAD Binding Chromatin Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion SMAD Protein Signal Transduction Calcium Channel Complex Spindle Pole Chromosome, Centromeric Region Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum DGDP Biosynthetic Process GDP Biosynthetic Process Organ Growth Condensed Nuclear Chromosome Calcitriol Binding Lithocholic Acid Binding Histone H2B Ubiquitin Ligase Activity Peptidyl-aspartic Acid 3-dioxygenase Activity Nucleoplasm Negative Regulation Of High Voltage-gated Calcium Channel Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Post-embryonic Retina Morphogenesis In Camera-type Eye Netrin Receptor Binding Homomeric SMAD Protein Complex Negative Regulation Of Phosphate Transmembrane Transport Nuclear Receptor-mediated Bile Acid Signaling Pathway Bile Acid Nuclear Receptor Activity Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Regulation Of Transmembrane Transporter Activity Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Roof Of Mouth Development Intracellular Signal Transduction Regulation Of Cardiac Muscle Contraction Regulation Of Monoatomic Ion Transmembrane Transporter Activity Glycoprotein Transport Zygotic Specification Of Dorsal/ventral Axis Activin Responsive Factor Complex Paraxial Mesoderm Morphogenesis Cis-regulatory Region Sequence-specific DNA Binding Establishment Of Meiotic Sister Chromatid Cohesion Chromosome Organization	Sister Chromatid Cohesion Cohesin Complex Establishment Of Mitotic Sister Chromatid Cohesion Mitotic Cohesin Complex Establishment Of Sister Chromatid Cohesion Anaphase-promoting Complex Binding Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Chromosome Segregation Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Spindle Organization Chromosome, Centromeric Region Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Negative Regulation Of Mitotic Metaphase/anaphase Transition Negative Regulation Of Cell Cycle Phase Transition Negative Regulation Of Mitotic Cell Cycle Mitotic Spindle Pole Negative Regulation Of Mitotic Nuclear Division Negative Regulation Of Cell Cycle Process Protein Localization To Chromatin Chromosome Organization Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Mitotic Sister Chromatid Separation Negative Regulation Of Cell Cycle Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle G2/M Phase Transition Regulation Of Proteolysis Regulation Of Chromosome Separation Negative Regulation Of Synaptic Vesicle Clustering Negative Regulation Of Chromosome Organization Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Serine/threonine Phosphatase Activity Regulation Of Cell Cycle Phase Transition Microtubule Cytoskeleton Organization Regulation Of Mitotic Metaphase/anaphase Transition Cell Division Mitotic Spindle Organization Spindle Assembly Regulation Of Sister Chromatid Segregation Regulation Of Mitotic Cell Cycle Nucleoplasm Protein Localization To Chromosome Synaptonemal Complex Disassembly Golgi Inheritance Regulation Of G2/M Transition Of Mitotic Cell Cycle Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity PML Body
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