STAG2

Description		STAG2 cohesin complex component
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GO Annotations	Cellular Component	Chromosome, Centromeric Region Chromatin Fibrillar Center Nucleus Nucleoplasm Chromosome Nucleolus Cytosol Cohesin Complex Membrane Nuclear Matrix Mitotic Cohesin Complex Mitotic Spindle Pole
	Molecular Function	Chromatin Binding Protein Binding
	Biological Process	Chromosome Segregation Sister Chromatid Cohesion Establishment Of Mitotic Sister Chromatid Cohesion Cell Division Meiotic Cell Cycle Mitotic Spindle Assembly
Pathways		Meiotic synapsis Separation of Sister Chromatids Establishment of Sister Chromatid Cohesion Cohesin Loading onto Chromatin Resolution of Sister Chromatid Cohesion SUMOylation of DNA damage response and repair proteins Estrogen-dependent gene expression
Drugs
Diseases
GWAS		Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494)
Interacting Genes		7 interacting genes: ITGB1BP2 PLK1 PTEN RAD21 SSU72 STAG1 SUMO2
Entrez ID		10735
HPRD ID		05077
Ensembl ID		ENSG00000101972
Uniprot IDs		Q8N3U4
PDB IDs		4PJU 4PJW 4PK7 6QNX 7ZJS 8K4D
Enriched GO Terms of Interacting Partners?		Sister Chromatid Cohesion Cohesin Complex Establishment Of Mitotic Sister Chromatid Cohesion Mitotic Cohesin Complex Establishment Of Sister Chromatid Cohesion Anaphase-promoting Complex Binding Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Chromosome Segregation Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Spindle Organization Chromosome, Centromeric Region Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Negative Regulation Of Mitotic Metaphase/anaphase Transition Negative Regulation Of Cell Cycle Phase Transition Negative Regulation Of Mitotic Cell Cycle Mitotic Spindle Pole Negative Regulation Of Mitotic Nuclear Division Negative Regulation Of Cell Cycle Process Protein Localization To Chromatin Chromosome Organization Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Mitotic Sister Chromatid Separation Negative Regulation Of Cell Cycle Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle G2/M Phase Transition Regulation Of Proteolysis Regulation Of Chromosome Separation Negative Regulation Of Synaptic Vesicle Clustering Negative Regulation Of Chromosome Organization Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Serine/threonine Phosphatase Activity Regulation Of Cell Cycle Phase Transition Microtubule Cytoskeleton Organization Regulation Of Mitotic Metaphase/anaphase Transition Cell Division Mitotic Spindle Organization Spindle Assembly Regulation Of Sister Chromatid Segregation Regulation Of Mitotic Cell Cycle Nucleoplasm Protein Localization To Chromosome Synaptonemal Complex Disassembly Golgi Inheritance Regulation Of G2/M Transition Of Mitotic Cell Cycle Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity PML Body
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