IRX5 and APLF

Number of citations of the paper that reports this interaction (PMID 17396150)
36

Data Source:
HPRD (in vitro)

		IRX5	APLF
Gene Name		iroquois homeobox 5	aprataxin and PNKP like factor
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus	Nucleus Nucleoplasm Cytosol Site Of Double-strand Break
	Molecular Function	Vitamin D Binding Sequence-specific DNA Binding	Nucleotide Binding DNA-(apurinic Or Apyrimidinic Site) Lyase Activity Endodeoxyribonuclease Activity Protein Binding 3'-5' Exonuclease Activity Metal Ion Binding
	Biological Process	Regulation Of Heart Rate Transcription, DNA-templated Regulation Of Transcription, DNA-templated Visual Perception Gonad Development Neuron Maturation Embryonic Cranial Skeleton Morphogenesis Response To Stimulus Retinal Bipolar Neuron Differentiation	Single Strand Break Repair DNA Catabolic Process, Endonucleolytic Double-strand Break Repair Cellular Response To DNA Damage Stimulus Regulation Of Isotype Switching Positive Regulation Of DNA Ligation Nucleic Acid Phosphodiester Bond Hydrolysis
Pathways
Drugs
Diseases
GWAS		Dialysis-related mortality ( 21546767)
Protein-Protein Interactions		1 interactors: APLF	9 interactors: APP FBXO25 GMCL1 IRX5 LIG4 PARP1 XRCC1 XRCC4 XRCC5
Entrez ID		10265	200558
HPRD ID		08395	09848
Ensembl ID		ENSG00000176842	ENSG00000169621
Uniprot IDs		P78411	Q8IW19
PDB IDs			2KQB 2KQC 2KQD 2KQE 2KUO
Enriched GO Terms of Interacting Partners?		Positive Regulation Of DNA Ligation Single Strand Break Repair Regulation Of Isotype Switching Regulation Of DNA Recombination DNA Catabolic Process, Endonucleolytic DNA Catabolic Process Positive Regulation Of DNA Metabolic Process Double-strand Break Repair Regulation Of Adaptive Immune Response Nucleic Acid Phosphodiester Bond Hydrolysis Regulation Of Lymphocyte Activation Aromatic Compound Catabolic Process Regulation Of Cell Activation	Establishment Of Integrated Proviral Latency Establishment Of Viral Latency Double-strand Break Repair Via Nonhomologous End Joining Response To X-ray Double-strand Break Repair DNA Repair Pro-B Cell Differentiation Immunoglobulin V(D)J Recombination DNA Ligation Involved In DNA Repair Cellular Response To DNA Damage Stimulus Lymphoid Progenitor Cell Differentiation DNA Ligation Response To Radiation Response To Ionizing Radiation Cellular Response To Lithium Ion DNA Metabolic Process Single Strand Break Repair Hematopoietic Progenitor Cell Differentiation Cell Differentiation Isotype Switching V(D)J Recombination Hemopoiesis Neuron Maturation Response To Lithium Ion DNA Recombination Somatic Recombination Of Immunoglobulin Gene Segments Immune System Development Regulation Of Neurogenesis Somatic Diversification Of Immunoglobulins Cellular Response To Stress Immunoglobulin Production Involved In Immunoglobulin Mediated Immune Response Generation Of Neurons B Cell Activation Involved In Immune Response Neurogenesis Response To Gamma Radiation Regulation Of Cell Development Neuron Apoptotic Process Leukocyte Differentiation Organ Development Immunoglobulin Production Nucleobase-containing Compound Metabolic Process Base-excision Repair Positive Regulation Of Fibroblast Proliferation Neuron Death T Cell Differentiation In Thymus Central Nervous System Development Multicellular Organismal Development Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Telomere Maintenance
Tagcloud ?		16q anaplasia anaplastic blastic confined deleted deletion deletions differentiating disturbed enriched favorable immature irx3 irx6 irxb mapped maturing neoplasm nephrogenesis notch overlap renewal rho sets smallest tubular wilms wts	acidic adp analogs ation binds chaperone chaperones chromatin collectively define eukaryotes exhibits h4 histone histones homologous localize modulates motif nap1l poly poorly preferentially reactions relaxation repair ribose ribosyl tetramer
Tagcloud (Difference) ?		16q anaplasia anaplastic blastic confined deleted deletion deletions differentiating disturbed enriched favorable immature irx3 irx6 irxb mapped maturing neoplasm nephrogenesis notch overlap renewal rho sets smallest tubular wilms wts	acidic adp analogs ation binds chaperone chaperones chromatin collectively define eukaryotes exhibits h4 histone histones homologous localize modulates motif nap1l poly poorly preferentially reactions relaxation repair ribose ribosyl tetramer
Tagcloud (Intersection) ?