ASIC3 and ASIC2

Number of citations of the paper that reports this interaction (PubMedID 10842183)
0

Data Source:
HPRD (in vivo)

		ASIC3	ASIC2
Description		acid sensing ion channel subunit 3	acid sensing ion channel subunit 2
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Membrane	Plasma Membrane Membrane Neuron Projection Neuronal Cell Body Dendritic Spine Synapse Postsynaptic Density Membrane
	Molecular Function	Monoatomic Cation Channel Activity Sodium Channel Activity Ligand-gated Sodium Channel Activity Enterobactin Transmembrane Transporter Activity PH-gated Sodium Channel Activity PH-gated Monoatomic Ion Channel Activity	Monoatomic Ion Channel Activity Monoatomic Cation Channel Activity Sodium Channel Activity Protein Binding Ligand-gated Sodium Channel Activity Monoatomic Ion-gated Channel Activity PH-gated Sodium Channel Activity
	Biological Process	Monoatomic Ion Transport Monoatomic Cation Transport Sodium Ion Transport Response To Heat Response To Mechanical Stimulus Response To Acidic PH Monoatomic Ion Transmembrane Transport Sodium Ion Transmembrane Transport Enterobactin Transport Detection Of Chemical Stimulus Involved In Sensory Perception Sensory Perception Of Sour Taste Detection Of Temperature Stimulus Involved In Sensory Perception Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Detection Of Mechanical Stimulus Involved In Sensory Perception Of Pain Detection Of Chemical Stimulus Involved In Sensory Perception Of Pain Detection Of Mechanical Stimulus Involved In Sensory Perception Establishment Of Localization In Cell Membrane Depolarization	Regulation Of Systemic Arterial Blood Pressure By Aortic Arch Baroreceptor Feedback Monoatomic Ion Transport Monoatomic Cation Transport Sodium Ion Transport Synapse Assembly Phototransduction Sensory Perception Of Sound Response To Mechanical Stimulus Response To Acidic PH Regulation Of Vasoconstriction Monoatomic Ion Transmembrane Transport Regulation Of Monoatomic Ion Transmembrane Transport Protein Localization To Synapse Sodium Ion Transmembrane Transport Regulation Of Membrane Potential Negative Regulation Of Apoptotic Process Sensory Perception Of Sour Taste Detection Of Mechanical Stimulus Involved In Sensory Perception Establishment Of Localization In Cell Positive Regulation Of Synapse Assembly Cellular Response To Xenobiotic Stimulus Cellular Response To Acidic PH Regulation Of Postsynapse Assembly
Pathways		Stimuli-sensing channels	Stimuli-sensing channels
Drugs		Agmatine	Amiloride
Diseases
GWAS		Eyebrow thickness ( 26926045)	Adult body size ( 32376654) Angiotensin-converting enzyme inhibitor intolerance ( 28030426) Autism ( 30675382) Cerebellum cortex volume ( 31530798) Chronotype ( 30696823) Clopidogrel active metabolite levels ( 28207573) Congenital heart disease (septal defects) ( 33201861) Femur bone mineral density x serum urate levels interaction ( 34046847) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) Longevity ( 26912274) Mosquito bite size ( 28199695) Plasma parathyroid hormone levels ( 30134803) Polycystic ovary syndrome ( 30343302) Serum bilirubin levels in metabolic syndrome ( 30621171) Severe gingival inflammation ( 28459102)
Interacting Genes		9 interacting genes: ASIC2 CSNK2A1 DLG4 GOPC LIN7B MAGI1 PATJ PRKACA STOM	4 interacting genes: ASIC1 ASIC3 PICK1 STOM
Entrez ID		9311	40
HPRD ID		10626	03471
Ensembl ID		ENSG00000213199	ENSG00000108684
Uniprot IDs		A0A090N7X8 A0A090N8Q1 A0A090N8Z6 Q9UHC3	Q16515
PDB IDs			6L6P
Enriched GO Terms of Interacting Partners?		Regulation Of Monoatomic Ion Transmembrane Transport Plasma Membrane Postsynaptic Density Membrane Regulation Of Monoatomic Ion Transport Bicellular Tight Junction Intracellular Protein Localization Cell Junction Establishment Of Protein Localization Regulation Of Cell Junction Assembly Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Establishment Or Maintenance Of Apical/basal Cell Polarity Protein Localization To Synapse Regulation Of Systemic Arterial Blood Pressure By Aortic Arch Baroreceptor Feedback Cellular Component Assembly Establishment Of Localization In Cell P2Y1 Nucleotide Receptor Binding Negative Regulation Of Anion Channel Activity Regulation Of Transport Neuromuscular Junction Protein Localization To Cell Junction Synapse PH-gated Sodium Channel Activity Monoatomic Ion-gated Channel Activity Anchoring Junction Cell Periphery Protein Kinase CK2 Complex Protein Transport Symbiont-mediated Disruption Of Host Cell PML Body Beta-1 Adrenergic Receptor Binding Regulation Of Grooming Behavior Negative Regulation Of Glycolytic Process Through Fructose-6-phosphate Protein Localization To Lipid Droplet Dendritic Spine Regulation Of System Process Positive Regulation Of Aggrephagy AMPA Glutamate Receptor Clustering Cell Projection Neuroligin Family Protein Binding MPP7-DLG1-LIN7 Complex Regulation Of Synapse Assembly NMDA Selective Glutamate Receptor Signaling Pathway Establishment Or Maintenance Of Cell Polarity CAMP-dependent Protein Kinase Activity	PH-gated Monoatomic Ion Channel Activity Sensory Perception Of Sour Taste Ligand-gated Sodium Channel Activity Response To Acidic PH Sensory Perception Of Taste Sodium Channel Activity Monoatomic Cation Channel Activity Response To PH Establishment Of Localization In Cell Enterobactin Transport Enterobactin Transmembrane Transporter Activity Sensory Perception Of Chemical Stimulus Sodium Ion Transmembrane Transport Monoatomic Ion-gated Channel Activity PH-gated Sodium Channel Activity Siderophore Transport Detection Of Chemical Stimulus Involved In Sensory Perception Of Pain Sodium Ion Transport Membrane Curvature Sensor Activity Plasma Membrane Negative Regulation Of Arp2/3 Complex-mediated Actin Nucleation Negative Regulation Of Neurotransmitter Secretion Inorganic Cation Transmembrane Transporter Activity Negative Regulation Of Actin Nucleation Negative Regulation Of Telomere Capping Host-mediated Perturbation Of Viral Genome Replication Host-mediated Activation Of Viral Genome Replication Neuronal Ion Channel Clustering Dendritic Spine Maintenance Ion Channel Inhibitor Activity Detection Of Mechanical Stimulus Involved In Sensory Perception Of Pain Arp2/3 Complex Binding Regulation Of Telomere Capping Long-term Synaptic Depression Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Sensory Perception Regulation Of Transport Cellular Response To PH Regulation Of Membrane Potential Modulation Of Chemical Synaptic Transmission Positive Regulation Of Protein Targeting To Membrane RNA Polymerase Binding Detection Of Mechanical Stimulus Involved In Sensory Perception Detection Of Temperature Stimulus Involved In Sensory Perception Detection Of Temperature Stimulus Positive Regulation Of Receptor Internalization Regulation Of Arp2/3 Complex-mediated Actin Nucleation Exon-exon Junction Complex Telomerase RNA Binding Telomeric DNA Binding
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