CHST4 and CD34

Number of citations of the paper that reports this interaction (PMID 10330415)
36

Data Source:
HPRD (in vitro)

		CHST4	CD34
Gene Name		carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 4	CD34 molecule
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Trans-Golgi Network Integral Component Of Membrane Intrinsic Component Of Golgi Membrane	Cytoplasm Lysosome Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Basal Plasma Membrane Apical Plasma Membrane Glomerular Endothelium Fenestra Intercellular Bridge Perinuclear Region Of Cytoplasm
	Molecular Function	N-acetylglucosamine 6-O-sulfotransferase Activity Sulfotransferase Activity	Transcription Factor Binding Carbohydrate Binding Sulfate Binding
	Biological Process	Carbohydrate Metabolic Process N-acetylglucosamine Metabolic Process Protein Sulfation Sulfur Compound Metabolic Process Movement Of Cell Or Subcellular Component Inflammatory Response Immune Response Cell Adhesion Cell-cell Signaling Leukocyte Tethering Or Rolling	Tissue Homeostasis Endothelial Cell Proliferation Glomerular Filtration Endothelium Development Signal Transduction Regulation Of Blood Pressure Cell Proliferation Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Single Organismal Cell-cell Adhesion Hemopoiesis Negative Regulation Of Blood Coagulation Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Interleukin-10 Production Mesangial Cell-matrix Adhesion Paracrine Signaling Positive Regulation Of Odontogenesis Negative Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Angiogenesis Cell Motility Regulation Of Immune Response Leukocyte Migration Transdifferentiation Vascular Wound Healing Hematopoietic Stem Cell Proliferation Positive Regulation Of Transforming Growth Factor Beta Production Positive Regulation Of Granulocyte Colony-stimulating Factor Production Extracellular Vesicular Exosome Assembly Glomerular Endothelium Development Stem Cell Proliferation Metanephric Glomerular Mesangial Cell Differentiation Negative Regulation Of Cellular Response To Heat Negative Regulation Of Cellular Response To Hypoxia Negative Regulation Of Interleukin-2 Secretion Positive Regulation Of Glial Cell Line-derived Neurotrophic Factor Secretion Negative Regulation Of Neuron Death Positive Regulation Of Vasculogenesis
Pathways
Drugs
Diseases
GWAS			Age-related macular degeneration ( 23326517) Heart rate ( 23583979) Resting heart rate ( 20639392)
Protein-Protein Interactions		2 interactors: CD34 DCPS	5 interactors: ATF5 CHST4 CREM CRKL PRKCD
Entrez ID		10164	947
HPRD ID		07477	00790
Ensembl ID		ENSG00000140835	ENSG00000174059
Uniprot IDs		Q8NCG5	B4DG27 P28906 Q5JTA5
PDB IDs
Enriched GO Terms of Interacting Partners?		Extracellular Vesicular Exosome Assembly Positive Regulation Of Glial Cell Line-derived Neurotrophic Factor Secretion Negative Regulation Of Cellular Response To Heat Mesangial Cell-matrix Adhesion Cellular Response To Menadione Positive Regulation Of Granulocyte Colony-stimulating Factor Production Positive Regulation Of Macrophage Colony-stimulating Factor Production Negative Regulation Of Interleukin-2 Secretion Negative Regulation Of Cellular Response To Hypoxia Regulation Of Macrophage Colony-stimulating Factor Production Vascular Wound Healing Paracrine Signaling Metanephric Glomerular Mesangial Cell Differentiation Regulation Of Cellular Response To Hypoxia Glomerular Endothelium Development Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Positive Regulation Of Odontogenesis Metanephric Glomerulus Vasculature Development Positive Regulation Of Vasculogenesis Cell Differentiation Involved In Metanephros Development Transdifferentiation Hematopoietic Stem Cell Proliferation Negative Regulation Of Nitric Oxide Biosynthetic Process Glomerular Filtration MRNA Cis Splicing, Via Spliceosome Renal Filtration Regulation Of Vasculogenesis Metanephric Glomerulus Development Endothelial Cell Proliferation Negative Regulation Of Reactive Oxygen Species Biosynthetic Process Angiogenesis Involved In Wound Healing Negative Regulation Of Interleukin-2 Production Negative Regulation Of Cell Death Positive Regulation Of Transforming Growth Factor Beta Production Glomerulus Vasculature Development Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic Regulation Of Odontogenesis Regulation Of Cellular Response To Heat Positive Regulation Of Interleukin-10 Production Negative Regulation Of Cytokine Secretion Negative Regulation Of Tumor Necrosis Factor Production Cell Differentiation Involved In Kidney Development Metanephric Nephron Development Negative Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Negative Regulation Of Reactive Oxygen Species Metabolic Process Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Regulation Of Cell Death Negative Regulation Of Blood Coagulation Regulation Of Nitric Oxide Biosynthetic Process	Positive Regulation Of Phospholipid Scramblase Activity Positive Regulation Of Glucosylceramide Catabolic Process Positive Regulation Of Sphingomyelin Catabolic Process Positive Regulation Of Phospholipid Catabolic Process Circadian Rhythm Interleukin-10 Production Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Filopodium Assembly Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Interleukin-12 Production Positive Regulation Of Ceramide Biosynthetic Process Olfactory Bulb Interneuron Development Regulation Of Ceramide Biosynthetic Process Rhythmic Process Positive Regulation Of Phospholipid Transport Negative Regulation Of Platelet Aggregation Positive Regulation Of Superoxide Anion Generation Negative Regulation Of Glial Cell Apoptotic Process Positive Regulation Of Metabolic Process Parathyroid Gland Development Protein Sulfation Positive Regulation Of Cellular Biosynthetic Process Olfactory Bulb Interneuron Differentiation Leukocyte Tethering Or Rolling Negative Regulation Of Astrocyte Differentiation Regulation Of Superoxide Anion Generation Regulation Of Platelet Aggregation Negative Regulation Of Platelet Activation Positive Regulation Of Protein Dephosphorylation Sulfation Neutrophil Activation Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress N-acetylglucosamine Metabolic Process Positive Regulation Of Lipid Catabolic Process Cellular Response To Growth Factor Stimulus Regulation Of Astrocyte Differentiation Negative Regulation Of Cellular Metabolic Process Response To Growth Factor Cellular Extravasation Regulation Of Platelet Activation Cellular Senescence Regulation Of MAPK Cascade Immune System Process Negative Regulation Of Glial Cell Differentiation Forebrain Neuron Development Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Negative Regulation Of Insulin Receptor Signaling Pathway Olfactory Bulb Development B Cell Proliferation
Tagcloud ?			agvhd alive allogeneic allografting allotransplantation anc ards august cgvhd donors evaluable february follows grades gvhd hematological leukaphereses mismatched mononucleated pbpc reach recipient scored september siblings sickle transplant unrelated unsupported
Tagcloud (Difference) ?			agvhd alive allogeneic allografting allotransplantation anc ards august cgvhd donors evaluable february follows grades gvhd hematological leukaphereses mismatched mononucleated pbpc reach recipient scored september siblings sickle transplant unrelated unsupported
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