AASS and ARF5

		AASS	ARF5
Description		aminoadipate-semialdehyde synthase	ARF GTPase 5
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GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Mitochondrial Matrix Cytosol	Cytoplasm Golgi Apparatus Plasma Membrane Membrane Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Transcription Corepressor Activity Catalytic Activity Saccharopine Dehydrogenase Activity Saccharopine Dehydrogenase (NAD+, L-lysine-forming) Activity Oxidoreductase Activity Histone Binding Saccharopine Dehydrogenase (NADP+, L-lysine-forming) Activity Saccharopine Dehydrogenase (NAD+, L-glutamate-forming) Activity	Nucleotide Binding GTPase Activity Protein Binding GTP Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Lysine Catabolic Process L-lysine Catabolic Process L-lysine Catabolic Process To Acetyl-CoA Via Saccharopine	Intracellular Protein Transport Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Protein Transport Vesicle-mediated Transport
Pathways		Lysine catabolism	COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic
Drugs		Glutamic acid NADH NADPH L-Saccharopine
Diseases		Hyperlysinemia
GWAS		Opioid dependence (time to event) ( 34124712)	Type 2 diabetes ( 23532257)
Interacting Genes		2 interacting genes: OGT WEE2-AS1	17 interacting genes: ACY3 AP1B1 AP3B1 ARFIP1 ARFIP2 ASAP2 DANCR DENND1A DENND1B DTX3 ERBB2 GGA1 GORAB IKBKG PIP5K1A RAB11FIP3 SNCA
Entrez ID		10157	381
HPRD ID		05489	00055
Ensembl ID		ENSG00000008311	ENSG00000004059
Uniprot IDs		A0A7P0T9N4 A4D0W4 Q9UDR5	A4D0Z3 P84085
PDB IDs		5L76 5L78 5O1N 5O1O 5O1P 8DDA 8E8T 8E8U 8E8V	2B6H
Enriched GO Terms of Interacting Partners?			Cellular Localization Establishment Of Localization In Cell Localization Within Membrane Trans-Golgi Network Membrane Intracellular Protein Localization Golgi Apparatus Clathrin-coated Vesicle Membrane Protein Transport Vesicle-mediated Transport To The Plasma Membrane Vesicle-mediated Transport Intracellular Transport Establishment Of Protein Localization Cytosol Clathrin Adaptor Complex Endocytic Recycling Protein Localization To Cell Periphery Protein Domain Specific Binding Melanosome Assembly Endosomal Transport Establishment Of Vesicle Localization GTP-dependent Protein Binding Small GTPase Binding Intracellular Protein Transport Platelet Dense Granule Organization Protein Localization To Membrane Vesicle Localization Phospholipid Binding Ruffle Organization Regulation Of Arp2/3 Complex-mediated Actin Nucleation Early Endosome Phosphatidylinositol Phosphate Binding Membrane Coat Phosphatidylinositol-4-phosphate Binding Protein Localization To Cell Surface Regulation Of Actin Nucleation Synaptic Vesicle Transport Golgi To Plasma Membrane Protein Transport Melanosome Organization Pigment Granule Organization Cytoplasmic Vesicle Membrane Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Saccharopine Dehydrogenase (NADP+, L-lysine-forming) Activity Saccharopine Dehydrogenase Activity Saccharopine Dehydrogenase (NAD+, L-lysine-forming) Activity Saccharopine Dehydrogenase (NAD+, L-glutamate-forming) Activity Negative Regulation Of Retrograde Transport, Endosome To Golgi
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