AKAP9 and ASB4

		AKAP9	ASB4
Description		A-kinase anchoring protein 9	ankyrin repeat and SOCS box containing 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Golgi Stack Cis-Golgi Network Centrosome Microtubule Organizing Center Cytosol Cytoskeleton Voltage-gated Potassium Channel Complex Potassium Channel Complex Neuronal Cell Body Dendritic Branch Synaptic Membrane Glutamatergic Synapse Extrinsic Component Of Postsynaptic Density Membrane	Cytoplasm Cytosol Cul2-RING Ubiquitin Ligase Complex Cul5-RING Ubiquitin Ligase Complex
	Molecular Function	DNA Binding Signaling Receptor Binding Protein Binding Potassium Channel Regulator Activity Protein Kinase A Regulatory Subunit Binding Transmembrane Transporter Binding Molecular Adaptor Activity Potassium Channel Activator Activity	Ubiquitin-protein Transferase Activity Protein Binding Enzyme Binding Ubiquitin Protein Ligase Binding Ubiquitin Protein Ligase Activity
	Biological Process	Microtubule Nucleation Signal Transduction Chemical Synaptic Transmission Positive Regulation Of Microtubule Polymerization Protein-containing Complex Localization Response To Electrical Stimulus Maintenance Of Centrosome Location Regulation Of Membrane Repolarization Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Cellular Response To CAMP Regulation Of Heart Rate By Cardiac Conduction Regulation Of Cardiac Muscle Cell Action Potential Involved In Regulation Of Contraction Regulation Of Golgi Organization	Protein Ubiquitination Intracellular Signal Transduction Protein Autoubiquitination Positive Regulation Of Vasculogenesis
Pathways		Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Phase 3 - rapid repolarisation Phase 2 - plateau phase Anchoring of the basal body to the plasma membrane Signaling by BRAF and RAF1 fusions AURKA Activation by TPX2	Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases		Long QT syndrome, including: Romano-Ward syndrome; Jervell and Lange-Nielsen syndrome (JLNS)
GWAS		Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced) ( 24236485) Appendicular lean mass ( 33097823) Breast cancer ( 29059683) Cerebrospinal fluid p-tau levels in mild cognitive impairment ( 29274321) Cerebrospinal fluid t-tau levels in mild cognitive impairment ( 29274321) Disrupted circadian rhythm (low relative amplitude of rest-activity cycles) ( 30120083) Hippocampal volume in Alzheimer's disease dementia ( 29274321) Red blood cell count ( 32888494)	BMI (adjusted for smoking behaviour) ( 28443625) Body mass index ( 25673413) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Metabolite levels ( 23823483) Middle childhood and early adolescence aggressive behavior ( 26087016)
Interacting Genes		85 interacting genes: ABI2 BEX2 BLZF1 C1orf94 CALM1 CALM2 CALM3 CASK CCDC116 CCDC146 CCP110 CDC5L CEP55 CLIC1 CSNK1D CSNK1E CTBP1 CTNNA3 DVL2 FAM90A1 FMR1 FNBP1 FXR2 GLIS2 GPC4 GRIN1 GTSE1 HDDC3 HNRNPM IKZF3 KCNQ1 KDM1A KIF19 KLC4 LMO1 MAGEA6 MAGED1 MED1 MYO5A NDEL1 PARD6G PCM1 PCNT PKN1 PKP2 PPP1CA PPP2R1B PPP2R3A PRC1 PRDM14 PRKAR2A PRKAR2B PRKCE RBM10 RBM14 RPA2 RSRC2 SAMD3 SCNM1 SF3B2 SLAIN1 SNF8 SNRPB SSX2 SSX3 SSX5 SUV39H2 TACC3 TCEANC TDP2 TENT5B THAP1 THOC1 TLX3 TNIK TRIP10 TSG101 TSNAX TUBGCP3 TULP3 USHBP1 USO1 VPS9D1 WAC YWHAE	3 interacting genes: HIF1AN ID2 UBE2D1
Entrez ID		10142	51666
HPRD ID		04921	05770
Ensembl ID		ENSG00000127914	ENSG00000005981
Uniprot IDs		A0A2R8Y590 Q5GIA7 Q6PJH3 Q99996	Q9Y574
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Calcium Ion Export Across Plasma Membrane Regulation Of Calcium Ion Export Across Plasma Membrane Cytoskeleton Negative Regulation Of Cation Transmembrane Transport Negative Regulation Of Monoatomic Ion Transmembrane Transport Negative Regulation Of Transporter Activity Cytoplasm Centrosome Nucleus Microtubule Nucleation Negative Regulation Of Monoatomic Ion Transport Regulation Of Heart Rate Adenylate Cyclase Activator Activity Negative Regulation Of Calcium Ion Transmembrane Transport Protein Binding Negative Regulation Of Transmembrane Transport Spindle Microtubule Transporter Inhibitor Activity Microtubule-based Process Regulation Of Cardiac Muscle Contraction Regulation Of Cytokinesis Regulation Of Cell Cycle Transmembrane Transporter Binding Negative Regulation Of Voltage-gated Calcium Channel Activity Negative Regulation Of Calcium Ion Transport Nucleoplasm Regulation Of Calcium Ion Transmembrane Transport Regulation Of Cardiac Muscle Cell Action Potential Regulation Of Metal Ion Transport Regulation Of Action Potential Regulation Of Striated Muscle Contraction Microtubule Cytoskeleton Organization Regulation Of Calcium Ion Transport Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Protein Domain Specific Binding Negative Regulation Of High Voltage-gated Calcium Channel Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Ubiquitin Protein Ligase Binding Spindle Titin Binding Calcium Channel Inhibitor Activity Protein Kinase A Catalytic Subunit Binding Regulation Of Monoatomic Ion Transport Regulation Of Heart Rate By Cardiac Conduction Regulation Of Voltage-gated Calcium Channel Activity Detection Of Calcium Ion Regulation Of Monoatomic Cation Transmembrane Transport Regulation Of Monoatomic Ion Transmembrane Transporter Activity Regulation Of Cell Communication By Electrical Coupling Regulation Of Transmembrane Transporter Activity	Negative Regulation Of B Cell Differentiation Negative Regulation Of Dopaminergic Neuron Differentiation Transmembrane Transporter Binding Peyer's Patch Development Bundle Of His Development Transcription Corepressor Activity Negative Regulation Of DNA-templated Transcription Enucleate Erythrocyte Differentiation Epithelial Cell Differentiation Involved In Mammary Gland Alveolus Development Negative Regulation Of Transcription By RNA Polymerase II Endodermal Digestive Tract Morphogenesis RNA Polymerase II-specific DNA-binding Transcription Factor Binding Mucosa-associated Lymphoid Tissue Development Negative Regulation Of RNA Biosynthetic Process Thigmotaxis Maintenance Of Centrosome Location Potassium Channel Activator Activity Regulation Of Cardiac Muscle Cell Action Potential Involved In Regulation Of Contraction Dendritic Branch Extrinsic Component Of Postsynaptic Density Membrane Ankyrin Repeat Binding [protein]-asparagine 3-dioxygenase Activity Peptidyl-aspartic Acid 3-dioxygenase Activity Carboxylic Acid Binding Peptidyl-histidine Dioxygenase Activity Oxygen Sensor Activity Negative Regulation Of RNA Metabolic Process Potassium Channel Complex Negative Regulation Of Nucleobase-containing Compound Metabolic Process Locomotor Rhythm Regulation Of Dopaminergic Neuron Differentiation Membranous Septum Morphogenesis Positive Regulation Of Astrocyte Differentiation Regulation Of Cellular Response To Growth Factor Stimulus Positive Regulation Of Vasculogenesis Ventricular Cardiac Muscle Tissue Development Negative Regulation Of Oligodendrocyte Differentiation Response To Lithium Ion Positive Regulation Of Macrophage Differentiation Embryonic Digestive Tract Morphogenesis Mammary Gland Epithelial Cell Differentiation Cellular Response To Lithium Ion Mammary Gland Alveolus Development Mammary Gland Epithelial Cell Proliferation White Fat Cell Differentiation Positive Regulation Of Protein Polyubiquitination Regulation Of Golgi Organization Regulation Of Vasculogenesis Natural Killer Cell Differentiation Cell Morphogenesis Involved In Neuron Differentiation
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