TSPAN3 and RXFP4

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		TSPAN3	RXFP4
Description		tetraspanin 3	relaxin family peptide/INSL5 receptor 4
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Extracellular Exosome	Plasma Membrane Membrane
	Molecular Function		G Protein-coupled Receptor Activity Galanin Receptor Activity Protein Binding
	Biological Process		Signal Transduction G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Positive Regulation Of Feeding Behavior
Pathways			G alpha (i) signalling events Relaxin receptors
Drugs
Diseases
GWAS		Hip circumference adjusted for BMI ( 34021172)	A body shape index ( 34021172) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		7 interacting genes: CLDN11 DRD2 EWSR1 LTB4R2 MC4R RXFP4 SLC13A1	10 interacting genes: ACTR10 GAPDH GJA8 KNG1 MAGED1 QDPR RLN3 TSPAN3 TTC4 TTI1
Entrez ID		10099	339403
HPRD ID		15512	16421
Ensembl ID		ENSG00000140391	ENSG00000173080
Uniprot IDs		O60637	Q8TDU9
PDB IDs			7YJ4 7YK6 7YK7
Enriched GO Terms of Interacting Partners?		Regulation Of Behavior G Protein-coupled Receptor Activity Regulation Of Feeding Behavior Feeding Behavior Plasma Membrane G Protein-coupled Receptor Complex Dopamine Neurotransmitter Receptor Activity, Coupled Via Gi/Go Positive Regulation Of Glial Cell-derived Neurotrophic Factor Production Positive Regulation Of Dopamine Uptake Involved In Synaptic Transmission Orbitofrontal Cortex Development G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Dopamine Receptor Signaling Pathway RNA Polymerase II, Holoenzyme Transcription Factor TFIIF Complex Melanocyte-stimulating Hormone Receptor Activity Response To Melanocyte-stimulating Hormone Sodium:sulfate Symporter Activity Monoatomic Anion:sodium Symporter Activity Neuropeptide Signaling Pathway Leukotriene B4 Receptor Activity Leukotriene Receptor Activity Dopamine Binding Dopamine Neurotransmitter Receptor Activity Cerebral Cortex GABAergic Interneuron Migration Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Circadian Sleep/wake Cycle, Sleep Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Negative Regulation Of Dephosphorylation Positive Regulation Of Renal Sodium Excretion Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Hyaloid Vascular Plexus Regression Branching Morphogenesis Of A Nerve Negative Regulation Of Dopamine Secretion Positive Regulation Of Neurotransmitter Uptake Regulation Of Locomotion Involved In Locomotory Behavior Melanocortin Receptor Activity Leukotriene Signaling Pathway Keratinocyte Migration Regulation Of Synapse Structural Plasticity Regulation Of Renal Sodium Excretion Interneuron Migration From The Subpallium To The Cortex Regulation Of Dopamine Uptake Involved In Synaptic Transmission Heterotrimeric G-protein Binding Nervous System Process Involved In Regulation Of Systemic Arterial Blood Pressure Phospholipase C-activating Dopamine Receptor Signaling Pathway Regulation Of Eating Behavior Secondary Active Sulfate Transmembrane Transporter Activity Galanin Receptor Activity Negative Regulation Of Synaptic Transmission, Glutamatergic Response To Histamine
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