GJC1 and SLC66A1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		GJC1	SLC66A1
Description		gap junction protein gamma 1	solute carrier family 66 member 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Gap Junction Connexin Complex Intercalated Disc Membrane Synapse Anchoring Junction	Lysosome Lysosomal Membrane Membrane Organelle Membrane
	Molecular Function	Monoatomic Ion Channel Activity Gap Junction Channel Activity Protein Binding Gap Junction Channel Activity Involved In SA Node Cell-atrial Cardiac Muscle Cell Electrical Coupling Gap Junction Channel Activity Involved In AV Node Cell-bundle Of His Cell Electrical Coupling	L-histidine Transmembrane Transporter Activity Protein Binding Basic Amino Acid Transmembrane Transporter Activity L-lysine Transmembrane Transporter Activity L-arginine Transmembrane Transporter Activity
	Biological Process	Vasculogenesis Muscle Contraction Cell-cell Junction Assembly Cell Communication Cell-cell Signaling Chemical Synaptic Transmission Heart Development Visual Perception Gap Junction Assembly Monoatomic Ion Transmembrane Transport Cell Development Cardiac Muscle Tissue Development Transmembrane Transport Atrial Cardiac Muscle Cell Action Potential SA Node Cell To Atrial Cardiac Muscle Cell Communication By Electrical Coupling AV Node Cell To Bundle Of His Cell Communication By Electrical Coupling	Amino Acid Transport Lysine Transport Transmembrane Transport Intracellular Amino Acid Homeostasis L-histidine Transmembrane Transport L-lysine Transmembrane Transport L-arginine Transmembrane Transport
Pathways		Electric Transmission Across Gap Junctions Gap junction assembly	Miscellaneous transport and binding events
Drugs
Diseases
GWAS
Interacting Genes		8 interacting genes: APOL3 CNST MEOX2 SLC66A1 TJP1 TJP3 TMEM86A UBQLN4	10 interacting genes: AQP6 GJA5 GJA8 GJC1 GPR152 GPRC5D NINJ2 SLC35H1 SLC39A2 SLC39A9
Entrez ID		10052	54896
HPRD ID		08819	17896
Ensembl ID		ENSG00000182963	ENSG00000040487
Uniprot IDs		P36383	A0A024RAA1 Q6ZP29
PDB IDs		3SHW
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Blood-brain Barrier Permeability Regulation Of Blood-brain Barrier Permeability Establishment Of Endothelial Intestinal Barrier Positive Regulation Of Vascular Permeability Protein Localization To Cell-cell Junction Maintenance Of Blood-brain Barrier Tight Junction Establishment Of Endothelial Barrier Endothelial Cell Development Regulation Of Vascular Permeability Protein Localization To Cell Junction Cell Adhesion Molecule Binding Lysine Transport Nuclear Proteasome Complex Alkenylglycerophosphocholine Hydrolase Activity Bicellular Tight Junction Negative Regulation Of Autophagosome Maturation Epithelial Cell Development Somite Specification Protein Localization To Bicellular Tight Junction Adherens Junction Maintenance Protein Localization To Adherens Junction L-lysine Transmembrane Transport L-lysine Transmembrane Transporter Activity L-histidine Transmembrane Transporter Activity L-histidine Transmembrane Transport Cytosolic Proteasome Complex Positive Regulation Of Golgi To Plasma Membrane Protein Transport Connexin Binding Cell-cell Junction Organization Anatomical Structure Homeostasis Tissue Homeostasis Ameloblast Differentiation Cell Junction Protein-containing Complex Basic Amino Acid Transmembrane Transporter Activity Intracellular Amino Acid Homeostasis L-arginine Transmembrane Transporter Activity Aromatic Amino Acid Transport K48-linked Polyubiquitin Modification-dependent Protein Binding Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin L-arginine Transmembrane Transport Regulation Of Golgi To Plasma Membrane Protein Transport Azole Transmembrane Transport Vascular Process In Circulatory System	Gap Junction Channel Activity Involved In SA Node Cell-atrial Cardiac Muscle Cell Electrical Coupling Gap Junction Gap Junction Channel Activity SA Node Cell To Atrial Cardiac Muscle Cell Communication By Electrical Coupling Connexin Complex Transmembrane Transport Gap Junction Channel Activity Involved In AV Node Cell-bundle Of His Cell Electrical Coupling SA Node Cell To Atrial Cardiac Muscle Cell Communication AV Node Cell To Bundle Of His Cell Communication By Electrical Coupling AV Node Cell To Bundle Of His Cell Communication Gap Junction Assembly Cell Communication By Electrical Coupling Involved In Cardiac Conduction Cell-cell Junction Assembly Cell Communication By Electrical Coupling Metal Ion Transmembrane Transporter Activity Cell Communication Involved In Cardiac Conduction Monoatomic Ion Transport Zinc Ion Transmembrane Transporter Activity Membrane Zinc Ion Transmembrane Transport Zinc Ion Transport Cell-cell Junction Organization Cardiac Muscle Cell Action Potential Involved In Contraction Cardiac Muscle Cell Action Potential Intercalated Disc Nitrate Transmembrane Transporter Activity Gap Junction Channel Activity Involved In Purkinje Myocyte-ventricular Cardiac Muscle Cell Electrical Coupling Mitral Valve Development Septum Primum Development Gap Junction Channel Activity Involved In Atrial Cardiac Muscle Cell-AV Node Cell Electrical Coupling Atrial Ventricular Junction Remodeling Gap Junction Channel Activity Involved In Bundle Of His Cell-Purkinje Myocyte Electrical Coupling Positive Regulation Of Cell Communication By Chemical Coupling Atrial Cardiac Muscle Cell To AV Node Cell Communication By Electrical Coupling Cell Junction Assembly Vasomotion Purkinje Myocyte To Ventricular Cardiac Muscle Cell Communication By Electrical Coupling Regulation Of Purkinje Myocyte Action Potential Monoatomic Ion Transmembrane Transport Cardiac Muscle Tissue Development Plasma Membrane PH-gated Chloride Channel Activity Nitrate Transmembrane Transport Foramen Ovale Closure Bundle Of His Cell To Purkinje Myocyte Communication By Electrical Coupling Regulation Of Bundle Of His Cell Action Potential Cell Communication By Chemical Coupling Pulmonary Valve Formation Atrial Cardiac Muscle Cell To AV Node Cell Communication Regulation Of Cellular Response To Testosterone Stimulus
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