GJC1 and CNST

Number of citations of the paper that reports this interaction (PubMedID 19864490)
62

Data Source:
BioGRID (pull down)

		GJC1	CNST
Description		gap junction protein gamma 1	consortin, connexin sorting protein
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Gap Junction Connexin Complex Intercalated Disc Membrane Synapse Anchoring Junction	Golgi Apparatus Trans-Golgi Network Plasma Membrane Membrane Transport Vesicle Cytoplasmic Vesicle Protein-containing Complex
	Molecular Function	Monoatomic Ion Channel Activity Gap Junction Channel Activity Protein Binding Gap Junction Channel Activity Involved In SA Node Cell-atrial Cardiac Muscle Cell Electrical Coupling Gap Junction Channel Activity Involved In AV Node Cell-bundle Of His Cell Electrical Coupling	Protein Binding Phosphatase Binding Connexin Binding
	Biological Process	Vasculogenesis Muscle Contraction Cell-cell Junction Assembly Cell Communication Cell-cell Signaling Chemical Synaptic Transmission Heart Development Visual Perception Gap Junction Assembly Monoatomic Ion Transmembrane Transport Cell Development Cardiac Muscle Tissue Development Transmembrane Transport Atrial Cardiac Muscle Cell Action Potential SA Node Cell To Atrial Cardiac Muscle Cell Communication By Electrical Coupling AV Node Cell To Bundle Of His Cell Communication By Electrical Coupling	Positive Regulation Of Golgi To Plasma Membrane Protein Transport
Pathways		Electric Transmission Across Gap Junctions Gap junction assembly
Drugs
Diseases
GWAS			Antisaccade task score ( 31596458)
Interacting Genes		8 interacting genes: APOL3 CNST MEOX2 SLC66A1 TJP1 TJP3 TMEM86A UBQLN4	13 interacting genes: EWSR1 GJA1 GJB1 GJB2 GJB3 GJB6 GJC1 PIGP POT1 PPP1CA PPP1CC ROPN1 SNCA
Entrez ID		10052	163882
HPRD ID		08819	08718
Ensembl ID		ENSG00000182963	ENSG00000162852
Uniprot IDs		P36383	Q6PJW8
PDB IDs		3SHW
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Blood-brain Barrier Permeability Regulation Of Blood-brain Barrier Permeability Establishment Of Endothelial Intestinal Barrier Positive Regulation Of Vascular Permeability Protein Localization To Cell-cell Junction Maintenance Of Blood-brain Barrier Tight Junction Establishment Of Endothelial Barrier Endothelial Cell Development Regulation Of Vascular Permeability Protein Localization To Cell Junction Cell Adhesion Molecule Binding Lysine Transport Nuclear Proteasome Complex Alkenylglycerophosphocholine Hydrolase Activity Bicellular Tight Junction Negative Regulation Of Autophagosome Maturation Epithelial Cell Development Somite Specification Protein Localization To Bicellular Tight Junction Adherens Junction Maintenance Protein Localization To Adherens Junction L-lysine Transmembrane Transport L-lysine Transmembrane Transporter Activity L-histidine Transmembrane Transporter Activity L-histidine Transmembrane Transport Cytosolic Proteasome Complex Positive Regulation Of Golgi To Plasma Membrane Protein Transport Connexin Binding Cell-cell Junction Organization Anatomical Structure Homeostasis Tissue Homeostasis Ameloblast Differentiation Cell Junction Protein-containing Complex Basic Amino Acid Transmembrane Transporter Activity Intracellular Amino Acid Homeostasis L-arginine Transmembrane Transporter Activity Aromatic Amino Acid Transport K48-linked Polyubiquitin Modification-dependent Protein Binding Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin L-arginine Transmembrane Transport Regulation Of Golgi To Plasma Membrane Protein Transport Azole Transmembrane Transport Vascular Process In Circulatory System	Connexin Complex Gap Junction Channel Activity Gap Junction Assembly Gap Junction Cell Communication By Electrical Coupling Gap Junction Channel Activity Involved In Cell Communication By Electrical Coupling Cell-cell Junction Assembly Cell-cell Signaling Cell-cell Junction Organization Signaling Cell Communication Anchoring Junction Cell Junction Organization Cell Junction Assembly Gap Junction-mediated Intercellular Transport PTW/PP1 Phosphatase Complex Cardiac Muscle Tissue Development Atrial Cardiac Muscle Cell Action Potential Intercellular Transport Presynapse Cell Communication By Electrical Coupling Involved In Cardiac Conduction Striated Muscle Tissue Development Cell Communication Involved In Cardiac Conduction Transmembrane Transport Entrainment Of Circadian Clock By Photoperiod Protein Phosphatase 1 Binding Cellular Component Assembly Muscle Tissue Development Photoperiodism Entrainment Of Circadian Clock Maintenance Of Blood-brain Barrier Chromosome, Telomeric Region Cardiac Muscle Cell Action Potential Involved In Contraction Response To Electrical Stimulus Cardiac Muscle Cell Action Potential Beta-tubulin Binding Cell Junction Alpha-tubulin Binding Kinesin Binding Intercalated Disc Postsynapse Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Positive Regulation Of DNA Strand Elongation Positive Regulation Of Telomeric D-loop Disassembly G-rich Single-stranded DNA Binding Glycogen Metabolic Process
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