CASP12 and CASP9

Number of citations of the paper that reports this interaction (PubMedID 12097332)
0

Data Source:
BioGRID (enzymatic study)

		CASP12	CASP9
Description		caspase 12 (gene/pseudogene)	caspase 9
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Cytosol NLRP1 Inflammasome Complex	Nucleus Cytoplasm Mitochondrion Cytosol Caspase Complex Protein-containing Complex Apoptosome
	Molecular Function	Cysteine-type Endopeptidase Activity Cysteine-type Peptidase Activity	Cysteine-type Endopeptidase Activity Protein Binding Enzyme Activator Activity Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Protein Kinase Binding Identical Protein Binding
	Biological Process	Proteolysis Apoptotic Process Regulation Of Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of Inflammatory Response	Response To Hypoxia Kidney Development Response To Ischemia Proteolysis Apoptotic Process DNA Damage Response Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To UV Protein Processing Platelet Formation Response To Cobalt Ion Response To Estradiol Response To Lipopolysaccharide Glial Cell Apoptotic Process Cellular Response To UV Signal Transduction In Response To DNA Damage Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Fibroblast Apoptotic Process Neuron Apoptotic Process Protein Maturation Cellular Response To Dexamethasone Stimulus Response To Indole-3-methanol Leukocyte Apoptotic Process Response To Anesthetic Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Execution Phase Of Apoptosis Epithelial Cell Apoptotic Process
Pathways			Formation of apoptosome Activation of caspases through apoptosome-mediated cleavage SMAC (DIABLO) binds to IAPs SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes NOD1/2 Signaling Pathway AKT phosphorylates targets in the cytosol Caspase activation via Dependence Receptors in the absence of ligand Constitutive Signaling by AKT1 E17K in Cancer Regulation of the apoptosome activity Regulation of the apoptosome activity
Drugs			Pamidronic acid
Diseases
GWAS		General risk tolerance (MTAG) ( 30643258) Schizophrenia ( 33169155) Self-reported risk-taking behaviour ( 30181555)	Alcoholic chronic pancreatitis ( 28754779) Estimated glomerular filtration rate ( 30604766) Glomerular filtration rate (creatinine) ( 26831199 28452372) Glomerular filtration rate in non diabetics (creatinine) ( 26831199) Orofacial cleft x maternal periconceptional multivitamin use interaction (1df) ( 33937227) Orofacial cleft x maternal periconceptional multivitamin use interaction (2df) ( 33937227) Serum metabolite levels ( 33031748) Urate levels ( 31578528) Urinary metabolite levels in chronic kidney disease ( 31959995)
Interacting Genes		2 interacting genes: CASP9 UBE2K	47 interacting genes: ABL1 AKT1 APAF1 ARNT BCL10 BCL2L1 BIRC2 BIRC3 BIRC5 BIRC6 BIRC7 BIRC8 CAPN2 CARD8 CASP10 CASP12 CASP3 CASP7 CASP8 CYCS DCC DIABLO DSP GMEB1 GZMB HECTD3 HIP1 HSD17B4 HSPD1 ILK JUN LYN MAP2K1 MAP2K2 MAPK1 MAPK3 MSTO1 MZB1 NAIP NLRP1 NOD1 PRKCZ RB1 RNF2 SRF VIM XIAP
Entrez ID		100506742	842
HPRD ID			03756
Ensembl ID			ENSG00000132906
Uniprot IDs		Q6UXS9	F8VVS7 P55211
PDB IDs			1JXQ 1NW9 2AR9 3D9T 3V3K 3YGS 4RHW 5JUY 5WVC 5WVE
Enriched GO Terms of Interacting Partners?		Caspase Complex Response To Anesthetic Apoptosome Glial Cell Apoptotic Process Response To Indole-3-methanol Free Ubiquitin Chain Polymerization Response To Cobalt Ion Fibroblast Apoptotic Process Positive Regulation Of Peptidyl-threonine Phosphorylation Filopodium Tip Ubiquitin-ubiquitin Ligase Activity Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Type I Interferon-mediated Signaling Pathway Positive Regulation Of Execution Phase Of Apoptosis Platelet Formation Cellular Response To Dexamethasone Stimulus Cellular Response To Interferon-beta Response To Interferon-beta Ubiquitin Conjugating Enzyme Activity Response To Dexamethasone Proteolysis Regulation Of Type I Interferon-mediated Signaling Pathway Leukocyte Apoptotic Process Epithelial Cell Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Cellular Response To Glucocorticoid Stimulus Cellular Response To Corticosteroid Stimulus Response To Ischemia Cysteine-type Endopeptidase Activity Type I Interferon-mediated Signaling Pathway Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Cytokine-mediated Signaling Pathway Interferon-mediated Signaling Pathway Positive Regulation Of Response To Cytokine Stimulus Enzyme Activator Activity Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Protein Polymerization	Programmed Cell Death Cell Death Apoptotic Process Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Regulation Of Cell Communication Regulation Of Signaling Execution Phase Of Apoptosis Positive Regulation Of Intracellular Signal Transduction Intracellular Signal Transduction Regulation Of Signal Transduction Cytoplasm Regulation Of Defense Response Regulation Of Inflammatory Response Positive Regulation Of Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Positive Regulation Of Programmed Cell Death Positive Regulation Of Defense Response Neuron Apoptotic Process Pyroptotic Inflammatory Response Bergmann Glial Cell Differentiation Regulation Of Golgi Inheritance Negative Regulation Of Apoptotic Process Cytosol Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Immune System Process Regulation Of Immune Response Cysteine-type Endopeptidase Inhibitor Activity Glial Cell Development Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Immune System Process Regulation Of Macromolecule Metabolic Process Regulation Of Canonical NF-kappaB Signal Transduction Apoptotic Signaling Pathway Regulation Of Protein Modification Process Schwann Cell Development Regulation Of Neuron Apoptotic Process Trachea Formation Response To Lipid Regulation Of Innate Immune Response Regulation Of Metabolic Process Face Development Positive Regulation Of Biosynthetic Process Thymus Development
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