CASP12

Description		caspase 12 (gene/pseudogene)
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Cytosol NLRP1 Inflammasome Complex
	Molecular Function	Cysteine-type Endopeptidase Activity Cysteine-type Peptidase Activity
	Biological Process	Proteolysis Apoptotic Process Regulation Of Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of Inflammatory Response
Pathways
Drugs
Diseases
GWAS		General risk tolerance (MTAG) ( 30643258) Schizophrenia ( 33169155) Self-reported risk-taking behaviour ( 30181555)
Interacting Genes		2 interacting genes: CASP9 UBE2K
Entrez ID		100506742
HPRD ID
Ensembl ID
Uniprot IDs		Q6UXS9
PDB IDs
Enriched GO Terms of Interacting Partners?		Caspase Complex Response To Anesthetic Apoptosome Glial Cell Apoptotic Process Response To Indole-3-methanol Free Ubiquitin Chain Polymerization Response To Cobalt Ion Fibroblast Apoptotic Process Positive Regulation Of Peptidyl-threonine Phosphorylation Filopodium Tip Ubiquitin-ubiquitin Ligase Activity Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Type I Interferon-mediated Signaling Pathway Positive Regulation Of Execution Phase Of Apoptosis Platelet Formation Cellular Response To Dexamethasone Stimulus Cellular Response To Interferon-beta Response To Interferon-beta Ubiquitin Conjugating Enzyme Activity Response To Dexamethasone Proteolysis Regulation Of Type I Interferon-mediated Signaling Pathway Leukocyte Apoptotic Process Epithelial Cell Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Cellular Response To Glucocorticoid Stimulus Cellular Response To Corticosteroid Stimulus Response To Ischemia Cysteine-type Endopeptidase Activity Type I Interferon-mediated Signaling Pathway Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Cytokine-mediated Signaling Pathway Interferon-mediated Signaling Pathway Positive Regulation Of Response To Cytokine Stimulus Enzyme Activator Activity Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Protein Polymerization
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