LINC02582 and MAPKAPK3

Number of citations of the paper that reports this interaction (PubMedID 31601781)
39

Data Source:
BioGRID (unspecified method)

		LINC02582	MAPKAPK3
Description		long intergenic non-protein coding RNA 2582	MAPK activated protein kinase 3
Image		No pdb structure
GO Annotations	Cellular Component		Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function		Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Calcium/calmodulin-dependent Protein Kinase Activity MAP Kinase Kinase Activity Protein Binding Calmodulin Binding ATP Binding Calcium-dependent Protein Serine/threonine Kinase Activity Kinase Activity Transferase Activity Mitogen-activated Protein Kinase Binding Protein Serine Kinase Activity
	Biological Process		MAPK Cascade Toll-like Receptor Signaling Pathway Signal Transduction Response To Lipopolysaccharide Response To Cytokine Intracellular Signal Transduction Macropinocytosis Vascular Endothelial Growth Factor Receptor Signaling Pathway
Pathways			p38MAPK events Oxidative Stress Induced Senescence VEGFA-VEGFR2 Pathway activated TAK1 mediates p38 MAPK activation
Drugs			2-[2-(2-FLUOROPHENYL)PYRIDIN-4-YL]-1,5,6,7-TETRAHYDRO-4H-PYRROLO[3,2-C]PYRIDIN-4-ONE 2-(2-QUINOLIN-3-YLPYRIDIN-4-YL)-1,5,6,7-TETRAHYDRO-4H-PYRROLO[3,2-C]PYRIDIN-4-ONE
Diseases
GWAS			Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cholangiocarcinoma in primary sclerosing cholangitis (time to event) ( 28779025) Cortical surface area (MOSTest) ( 32665545) Depressive symptom (appetite changes) (binary trait) ( 31530331) Depressive symptoms (binary sum-score) ( 31530331) Depressive symptoms (sum-score) ( 31530331) High light scatter reticulocyte count ( 32888494) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		10 interacting genes: A2M ACTB ALB APOE HBB HPX IGLC6 MAPKAPK3 UMOD USP7	21 interacting genes: APP ATF1 BECN1 COPS6 EEF2 EEF2K EZH2 HSPB1 IGHM LINC02582 MAPK13 MAPK14 NEDD4 NEDD4L RAB2A RCSD1 SMS SRPK2 SUMO3 TCF3 THAP12
Entrez ID		100505817	7867
HPRD ID			03678
Ensembl ID		ENSG00000261780	ENSG00000114738
Uniprot IDs			Q16644
PDB IDs			3FHR 3FXW 3R1N 3SHE 7NRB
Enriched GO Terms of Interacting Partners?		Blood Microparticle Extracellular Space Endocytic Vesicle Lumen Cellular Oxidant Detoxification Extracellular Region Extracellular Exosome Cellular Detoxification Regulation Of Immune Response Regulation Of Innate Immune Response Regulation Of Immune System Process Oxygen Binding Antioxidant Activity One-carbon Compound Transport Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Nitric Oxide Metabolic Process Platelet Alpha Granule Lumen Regulation Of Humoral Immune Response Platelet Aggregation Tau Protein Binding Positive Regulation Of Norepinephrine Uptake Cellular Response To Cytochalasin B Homotypic Cell-cell Adhesion Negative Regulation Of Phospholipid Efflux Regulation Of Nitric Oxide Biosynthetic Process Negative Regulation Of Postsynaptic Membrane Organization Positive Regulation Of Lipid Transport Across Blood-brain Barrier Negative Regulation Of Lipid Transport Across Blood-brain Barrier Regulation Of Cellular Response To Very-low-density Lipoprotein Particle Stimulus Metal Chelating Activity Regulation Of Nitric Oxide Metabolic Process Intermediate-density Lipoprotein Particle Clearance Renal Absorption Citric Acid Secretion Regulation Of Defense Response Negative Regulation Of Complement Activation, Lectin Pathway Regulation Of Norepinephrine Uptake Enterobactin Binding Exogenous Protein Binding Cellular Response To Calcium Ion Starvation Positive Regulation Of Presynaptic Membrane Organization Chylomicron Remnant Lipid Transport Involved In Lipid Storage Lipoprotein Particle Positive Regulation Of Neurofibrillary Tangle Assembly Discoidal High-density Lipoprotein Particle Metanephric Thick Ascending Limb Development Protein Transport Into Plasma Membrane Raft Micturition Regulation Of Protein Localization Intracellular Monoatomic Cation Homeostasis	Response To Growth Factor Cellular Response To Growth Factor Stimulus Receptor Catabolic Process Response To Hydrogen Peroxide Regulation Of Dendrite Development Response To Nerve Growth Factor Cellular Response To Nerve Growth Factor Stimulus Negative Regulation Of Potassium Ion Export Across Plasma Membrane Receptor Metabolic Process Regulation Of Synapse Organization Response To Metal Ion Positive Regulation Of Cell Cycle Response To Reactive Oxygen Species Sodium Channel Inhibitor Activity Cellular Response To Brain-derived Neurotrophic Factor Stimulus Regulation Of Dendrite Morphogenesis Potassium Channel Inhibitor Activity Cellular Response To Hydrogen Peroxide Regulation Of Potassium Ion Export Across Plasma Membrane Regulation Of Plasma Membrane Bounded Cell Projection Organization Response To Stress Negative Regulation Of Sodium Ion Transport Regulation Of Cell Projection Organization Regulation Of Neuron Projection Development Cellular Response To UV MAP Kinase Activity Response To Lead Ion Regulation Of Cell Cycle Positive Regulation Of Cellular Component Organization Positive Regulation Of Metabolic Process Protein Metabolic Process Regulation Of Protein Metabolic Process Response To Other Organism Cellular Response To Copper Ion Cellular Response To Light Stimulus Stress-activated MAPK Cascade Cellular Response To Reactive Oxygen Species Cellular Response To Chemical Stress Negative Regulation Of Potassium Ion Transmembrane Transport Intracellular Transport Cytosol Positive Regulation Of Transport Vesicle-mediated Transport Cellular Response To Stress P38MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Viral Budding Lysosomal Transport Intracellular Signaling Cassette Extracellular Exosome
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?