LINC02582 and UMOD

Number of citations of the paper that reports this interaction (PubMedID 31601781)
39

Data Source:
BioGRID (unspecified method)

		LINC02582	UMOD
Description		long intergenic non-protein coding RNA 2582	uromodulin
Image		No pdb structure
GO Annotations	Cellular Component		Spindle Pole Extracellular Region Extracellular Space Endoplasmic Reticulum Golgi Lumen Plasma Membrane Cilium Cell Surface Membrane Basolateral Plasma Membrane Apical Plasma Membrane Extrinsic Component Of Membrane Cell Projection Ciliary Membrane Extracellular Exosome Side Of Membrane
	Molecular Function		Calcium Ion Binding Protein Binding IgG Binding
	Biological Process		Kidney Development Organ Or Tissue Specific Immune Response Immune System Process Renal Water Homeostasis Glomerular Filtration Lipid Metabolic Process Intracellular Calcium Ion Homeostasis Intracellular Sodium Ion Homeostasis Autophagy Apoptotic Process Inflammatory Response Cellular Defense Response Response To Unfolded Protein Endoplasmic Reticulum Organization Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Leukocyte Cell-cell Adhesion Regulation Of Blood Pressure Negative Regulation Of Cell Population Proliferation RNA Splicing Response To Xenobiotic Stimulus Response To Water Deprivation Gene Expression Urate Transport Intracellular Phosphate Ion Homeostasis Intracellular Chloride Ion Homeostasis Response To Lipopolysaccharide Tumor Necrosis Factor-mediated Signaling Pathway Cellular Response To Stress Multicellular Organismal Response To Stress Cellular Response To Unfolded Protein Response To Endoplasmic Reticulum Stress Regulation Of Urine Volume ERAD Pathway Protein Transport Into Plasma Membrane Raft Innate Immune Response Citric Acid Secretion Multicellular Organismal-level Homeostasis Chemical Homeostasis Monoatomic Ion Homeostasis Defense Response To Gram-negative Bacterium Multicellular Organismal-level Water Homeostasis Regulation Of Protein Transport Phosphate Ion Homeostasis Chloride Ion Homeostasis Calcium Ion Homeostasis Potassium Ion Homeostasis Sodium Ion Homeostasis Micturition Renal Sodium Ion Absorption Urea Transmembrane Transport Collecting Duct Development Juxtaglomerular Apparatus Development Loop Of Henle Development Metanephric Ascending Thin Limb Development Metanephric Distal Convoluted Tubule Development Metanephric Thick Ascending Limb Development Protein Localization To Vacuole Apoptotic Signaling Pathway Connective Tissue Replacement Renal Urate Salt Excretion Antibacterial Innate Immune Response Neutrophil Migration
Pathways			Asparagine N-linked glycosylation
Drugs
Diseases			Nephronophthisis-medullary cystic kidney disease, including; Nephronophthisis (NPH) ; Nephronophthisis-like nephropathy 1; Medullary cystic kidney disease 1; Medullary cystic kidney disease 2 (MSKD2) Uromodulin-associated kidney diseases, including: Medullary cystic kidney disease 2; Familial juvenile hyperuremic nephropathy; Glomerulocystic kidney disease
GWAS			Chronic kidney disease ( 20383146 29124443 26831199) Chronic kidney disease and serum creatinine levels ( 20686651) Chronic kidney disease x type 2 diabetes interaction ( 32541925) Creatinine levels ( 29124443) Diastolic blood pressure ( 27841878) Diastolic blood pressure x smoking status (ever vs never) interaction (1df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Estimated glomerular filtration rate ( 31015462 30604766 29124443) Estimated glomerular filtration rate (creatinine, CKDi25) ( 33137338) Estimated glomerular filtration rate (creatinine, Rapid3) ( 33137338) Femoral neck bone geometry ( 22087292) Glomerular filtration rate ( 27588450) Glomerular filtration rate (creatinine) ( 28452372 26831199) Glomerular filtration rate (cystatin C) ( 28452372) Glomerular filtration rate in diabetes ( 29703844) Glomerular filtration rate in diabetics (creatinine) ( 26831199) Glomerular filtration rate in non diabetics (creatinine) ( 26831199) Glomerular filtration rate in type 2 diabetes ( 29703844) Hypertension ( 27618447 21082022) Hyperuricemia ( 29124443) Kidney function decline traits ( 25493955) Kidney stones ( 31729369) Medication use (calcium channel blockers) ( 31015401) Renal function and chronic kidney disease ( 19430482) Renal function-related traits (eGRFcrea) ( 22797727) Renal function-related traits (sCR) ( 22797727) Serum uric acid levels ( 29124443) Type 1 diabetes ( 34127860) Urate levels ( 31578528) Urinary uromodulin levels ( 24578125)
Interacting Genes		10 interacting genes: A2M ACTB ALB APOE HBB HPX IGLC6 MAPKAPK3 UMOD USP7	4 interacting genes: LINC02582 LTA MMP8 TMEM132D
Entrez ID		100505817	7369
HPRD ID			11771
Ensembl ID		ENSG00000261780	ENSG00000169344
Uniprot IDs			P07911
PDB IDs			4WRN 6TQK 6TQL 6ZS5 6ZYA 7PFP 7Q3N
Enriched GO Terms of Interacting Partners?		Blood Microparticle Extracellular Space Endocytic Vesicle Lumen Cellular Oxidant Detoxification Extracellular Region Extracellular Exosome Cellular Detoxification Regulation Of Immune Response Regulation Of Innate Immune Response Regulation Of Immune System Process Oxygen Binding Antioxidant Activity One-carbon Compound Transport Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Nitric Oxide Metabolic Process Platelet Alpha Granule Lumen Regulation Of Humoral Immune Response Platelet Aggregation Tau Protein Binding Positive Regulation Of Norepinephrine Uptake Cellular Response To Cytochalasin B Homotypic Cell-cell Adhesion Negative Regulation Of Phospholipid Efflux Regulation Of Nitric Oxide Biosynthetic Process Negative Regulation Of Postsynaptic Membrane Organization Positive Regulation Of Lipid Transport Across Blood-brain Barrier Negative Regulation Of Lipid Transport Across Blood-brain Barrier Regulation Of Cellular Response To Very-low-density Lipoprotein Particle Stimulus Metal Chelating Activity Regulation Of Nitric Oxide Metabolic Process Intermediate-density Lipoprotein Particle Clearance Renal Absorption Citric Acid Secretion Regulation Of Defense Response Negative Regulation Of Complement Activation, Lectin Pathway Regulation Of Norepinephrine Uptake Enterobactin Binding Exogenous Protein Binding Cellular Response To Calcium Ion Starvation Positive Regulation Of Presynaptic Membrane Organization Chylomicron Remnant Lipid Transport Involved In Lipid Storage Lipoprotein Particle Positive Regulation Of Neurofibrillary Tangle Assembly Discoidal High-density Lipoprotein Particle Metanephric Thick Ascending Limb Development Protein Transport Into Plasma Membrane Raft Micturition Regulation Of Protein Localization Intracellular Monoatomic Cation Homeostasis	Response To Molecule Of Bacterial Origin Response To Lipopolysaccharide Positive Regulation Of Chronic Inflammatory Response Regulation Of Chronic Inflammatory Response Positive Regulation Of Chronic Inflammatory Response To Antigenic Stimulus Positive Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Positive Regulation Of Inflammatory Response Positive Regulation Of Microglial Cell Activation Tumor Necrosis Factor Binding
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