CLDN20 and CNIH3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CLDN20	CNIH3
Description		claudin 20	cornichon family AMPA receptor auxiliary protein 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Golgi Apparatus Cytosol Plasma Membrane Bicellular Tight Junction Membrane Tight Junction Anchoring Junction	Endoplasmic Reticulum Membrane Plasma Membrane ER To Golgi Transport Vesicle Membrane Membrane Dendrite AMPA Glutamate Receptor Complex Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Dendritic Shaft Synapse Postsynaptic Membrane Glutamatergic Synapse
	Molecular Function	Structural Molecule Activity Protein Binding Identical Protein Binding	Signaling Receptor Binding Protein Binding Channel Regulator Activity
	Biological Process	Cell Adhesion Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Bicellular Tight Junction Assembly	Vesicle-mediated Transport Synaptic Transmission, Glutamatergic Regulation Of Membrane Potential Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Regulation Of AMPA Receptor Activity
Pathways		Tight junction interactions	COPII-mediated vesicle transport Cargo concentration in the ER
Drugs
Diseases
GWAS		Dimensional psychopathology (Arousal) ( 29496196) Dimensional psychopathology (Negative) ( 29496196) Waist-hip ratio ( 28552196) Waist-to-hip ratio adjusted for BMI ( 28552196)	Cancer ( 29299148) Gut microbiota relative abundance (Streptococcus) ( 33208821) Low density lipoprotein cholesterol levels ( 32154731) Mean corpuscular hemoglobin ( 32888494) Neonatal white matter microstructure ( 33009551) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494) Opioid dependence ( 26239289) White blood cell count ( 32888494)
Interacting Genes		7 interacting genes: ANKRD46 APP CNIH3 IGFBP5 MAL PLP1 TMEM239	28 interacting genes: AQP6 BIK CD79A CEACAM3 CLDN20 ERGIC3 FAM210B FNDC9 GPX8 KCNN4 LEUTX LMNA LRRC25 NEMP1 ODF4 PLD3 SLC16A2 SMIM3 SORT1 STOM SUSD3 TMEM14B TMEM237 TMEM31 TMEM52B TMEM80 TMPRSS2 VSIR
Entrez ID		49861	149111
HPRD ID		13067	08799
Ensembl ID		ENSG00000171217	ENSG00000143786
Uniprot IDs		A0A140VKA2 P56880	Q8TBE1
PDB IDs
Enriched GO Terms of Interacting Partners?		Structural Constituent Of Myelin Sheath Central Nervous System Myelination Amyloid-beta Complex Dendritic Shaft Growth Cone Lamellipodium Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Trans-synaptic Signaling Chemical Synaptic Transmission Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Cellular Response To CAMP Synaptic Signaling Glial Cell Development Negative Regulation Of Skeletal Muscle Hypertrophy Protein Insertion Into Plasma Membrane Hinge Region Between Urothelial Plaques Of Apical Plasma Membrane Response To CAMP Myelination Axon Ensheathment Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Receptor Ligand Activity Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Insulin-like Growth Factor Binding Protein Complex Membrane Raft Polarization Cell-cell Signaling Response To Purine-containing Compound Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Central Nervous System Development Positive Regulation Of Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Signaling Insulin-like Growth Factor Ternary Complex Protein Localization To Paranode Region Of Axon Regulation Of Extrinsic Apoptotic Signaling Pathway Cell Communication Intermediate-density Lipoprotein Particle	Membrane
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