CDH4

Description		cadherin 4
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Adherens Junction Membrane Catenin Complex
	Molecular Function	Calcium Ion Binding Beta-catenin Binding Cadherin Binding Metal Ion Binding
	Biological Process	Cell Morphogenesis Cell-cell Junction Assembly Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Axon Guidance Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Cell Migration Adherens Junction Organization Cell-cell Adhesion Mediated By Cadherin Positive Regulation Of Axon Extension Axon Extension Cell-cell Adhesion
Pathways		Adherens junctions interactions Myogenesis Myogenesis
Drugs
Diseases
GWAS		β2-Glycoprotein I (β2-GPI) plasma levels ( 23279374) 3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134) Axial length ( 24144296) Cerebrospinal T-tau levels ( 20932310) Cognitive decline rate in late mild cognitive impairment ( 26252872) Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes ( 29221444) Erosive tooth wear (severe vs non-severe) ( 29898447) Erosive tooth wear (severe vs none or mild) ( 29898447) Femur bone mineral density x serum urate levels interaction ( 34046847) Fish intake frequency ( 31320941) General cognitive ability ( 29844566) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Gut microbiota relative abundance (unassigned genus belonging to family Lachnospiraceae) ( 33208821) HDL cholesterol levels ( 32759990) Hip circumference adjusted for BMI ( 28552196) Household income (MTAG) ( 31844048) Longevity ( 20834067) Metabolite levels ( 23823483) Metabolite levels (X-11787) ( 23934736) Multiple system atrophy ( 27629089) Night sleep phenotypes ( 27126917) Obesity-related traits ( 23251661) Obstructive sleep apnea trait (average respiratory event duration) ( 26977737) Sudden cardiac arrest ( 21658281) Volumetric brain MRI ( 17903297)
Interacting Genes		3 interacting genes: CDH2 MTNR1B UBE2I
Entrez ID		1002
HPRD ID		04304
Ensembl ID		ENSG00000179242
Uniprot IDs		P55283
PDB IDs
Enriched GO Terms of Interacting Partners?		Detection Of Muscle Stretch Regulation Of Oligodendrocyte Progenitor Proliferation Positive Regulation Of Cell Communication Positive Regulation Of Synaptic Vesicle Clustering Regulation Of Synaptic Vesicle Clustering Regulation Of Postsynaptic Density Protein 95 Clustering Neuroligin Clustering Involved In Postsynaptic Membrane Assembly Melatonin Receptor Activity Positive Regulation Of Transmission Of Nerve Impulse Positive Regulation Of Circadian Sleep/wake Cycle, Sleep Negative Regulation Of CGMP-mediated Signaling Regulation Of Neuronal Action Potential Negative Regulation Of Transmission Of Nerve Impulse Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep RING-like Zinc Finger Domain Binding SUMO Ligase Complex Small Protein Activating Enzyme Binding HLH Domain Binding SUMO Conjugating Enzyme Activity Fascia Adherens Enzyme Binding Regulation Of Intracellular Signal Transduction Alpha-catenin Binding Mitotic Nuclear Membrane Reassembly Gamma-catenin Binding Synaptic Vesicle Clustering Type B Pancreatic Cell Development Radial Glial Cell Differentiation Negative Regulation Of Vasoconstriction Regulation Of CGMP-mediated Signaling Transferase Complex Negative Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Transmission Of Nerve Impulse Brain Morphogenesis Positive Regulation Of Circadian Rhythm Negative Regulation Of Nervous System Process Regulation Of Circadian Sleep/wake Cycle, Sleep Transcription Factor Binding SUMO Transferase Activity Apicolateral Plasma Membrane Neuronal Stem Cell Population Maintenance Regulation Of Circadian Sleep/wake Cycle Synaptonemal Complex Telencephalon Development Response To Muscle Stretch Catenin Complex Neural Crest Cell Development Desmosome Positive Regulation Of Behavior
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