UBE4A and SC5D

		UBE4A	SC5D
Description		ubiquitination factor E4A	sterol-C5-desaturase
Image			No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Cytoplasm	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Transferase Activity Ubiquitin-ubiquitin Ligase Activity Ubiquitin Protein Ligase Activity	C-5 Sterol Desaturase Activity Iron Ion Binding Oxidoreductase Activity Delta7-sterol 5(6)-desaturase Activity
	Biological Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination ERAD Pathway	Lipid Metabolic Process Steroid Biosynthetic Process Cholesterol Biosynthetic Process Steroid Metabolic Process Lipid Biosynthetic Process Sterol Biosynthetic Process Cholesterol Biosynthetic Process Via Desmosterol Cholesterol Biosynthetic Process Via Lathosterol Negative Regulation Of Ferroptosis
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Activation of gene expression by SREBF (SREBP) Cholesterol biosynthesis via desmosterol Cholesterol biosynthesis via lathosterol
Drugs
Diseases
GWAS		Celiac disease and Rheumatoid arthritis ( 26546613) Fat distribution (HIV) ( 21897333)
Interacting Genes		17 interacting genes: CASP6 CLIC6 EPHA2 FILNC1 GZMB IP6K1 MAVS NFE2L1 PTTG1 RSAD2 SC5D SLA UBE2D1 UBE2D2 UBE2D3 UBE2D4 VCP	7 interacting genes: CGREF1 FRMD5 RPS25 SCN4B SLC19A2 UBE4A VGLL1
Entrez ID		9354	6309
HPRD ID		06793	09078
Ensembl ID		ENSG00000110344	ENSG00000109929
Uniprot IDs		Q14139	O75845
PDB IDs		1WGM
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Protein K48-linked Ubiquitination Protein Polyubiquitination Protein Ubiquitination Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation Proteolysis Post-translational Protein Modification Ubiquitin-protein Transferase Activity Regulation Of Protein Localization Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process ATP Binding Molecular Function Activator Activity Protein K6-linked Ubiquitination Positive Regulation Of Establishment Of Protein Localization To Mitochondrion Pyroptotic Inflammatory Response Nucleotide Binding Notochord Cell Development Regulation Of Nucleus Organization Delta7-sterol 5(6)-desaturase Activity Protein K11-linked Ubiquitination Flavin Adenine Dinucleotide Catabolic Process D4 Dopamine Receptor Binding Positive Regulation Of IP-10 Production Negative Regulation Of Viral Genome Replication Response To Stress Axial Mesoderm Formation Regulation Of Establishment Of Protein Localization Cytolytic Granule Lumen C-5 Sterol Desaturase Activity Negative Regulation Of BMP Signaling Pathway VCP-NSFL1C Complex Endoplasmic Reticulum Stress-induced Pre-emptive Quality Control Positive Regulation Of Protein K63-linked Deubiquitination D3 Dopamine Receptor Binding Regulation Of Peroxisome Organization Negative Regulation Of Lymphangiogenesis Notochord Formation Alcohol Metabolic Process Cholesterol Biosynthetic Process Via Lathosterol Cholesterol Biosynthetic Process Via Desmosterol Macromolecule Catabolic Process Protein Autoubiquitination Cellular Response To Arsenite Ion Mitotic Spindle Disassembly Positive Regulation Of Oxidative Phosphorylation Inositol 5-diphosphate Pentakisphosphate 5-kinase Activity Diphosphoinositol Tetrakisphosphate Kinase Activity D2 Dopamine Receptor Binding	Voltage-gated Sodium Channel Activity Involved In Cardiac Muscle Cell Action Potential AV Node Cell Action Potential Pyridoxine Transport Thiamine Transmembrane Transporter Activity Thiamine Transport Folic Acid Transmembrane Transporter Activity Thiamine Diphosphate Metabolic Process Thiamine Diphosphate Biosynthetic Process Thiamine Transmembrane Transport Vitamin Transmembrane Transporter Activity Thiamine-containing Compound Metabolic Process Folic Acid Transport
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