SC5D and CGREF1

		SC5D	CGREF1
Description		sterol-C5-desaturase	cell growth regulator with EF-hand domain 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane	Extracellular Region
	Molecular Function	C-5 Sterol Desaturase Activity Iron Ion Binding Oxidoreductase Activity Delta7-sterol 5(6)-desaturase Activity	Calcium Ion Binding Protein Binding Metal Ion Binding
	Biological Process	Lipid Metabolic Process Steroid Biosynthetic Process Cholesterol Biosynthetic Process Steroid Metabolic Process Lipid Biosynthetic Process Sterol Biosynthetic Process Cholesterol Biosynthetic Process Via Desmosterol Cholesterol Biosynthetic Process Via Lathosterol Negative Regulation Of Ferroptosis	Cell Adhesion Negative Regulation Of Cell Population Proliferation Regulation Of Cell Cycle
Pathways		Activation of gene expression by SREBF (SREBP) Cholesterol biosynthesis via desmosterol Cholesterol biosynthesis via lathosterol
Drugs
Diseases
GWAS			Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Left–right brain asymmetry ( 33723403) Response to cytadine analogues (cytosine arabinoside) ( 24483146) Self-reported risk-taking behaviour ( 30271922) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		7 interacting genes: CGREF1 FRMD5 RPS25 SCN4B SLC19A2 UBE4A VGLL1	4 interacting genes: AQP6 CFTR RTN4 SC5D
Entrez ID		6309	10669
HPRD ID		09078	09365
Ensembl ID		ENSG00000109929	ENSG00000138028
Uniprot IDs		O75845	Q99674
PDB IDs
Enriched GO Terms of Interacting Partners?		Voltage-gated Sodium Channel Activity Involved In Cardiac Muscle Cell Action Potential AV Node Cell Action Potential Pyridoxine Transport Thiamine Transmembrane Transporter Activity Thiamine Transport Folic Acid Transmembrane Transporter Activity Thiamine Diphosphate Metabolic Process Thiamine Diphosphate Biosynthetic Process Thiamine Transmembrane Transport Vitamin Transmembrane Transporter Activity Thiamine-containing Compound Metabolic Process Folic Acid Transport	Fluid Transport Water Transport Cholesterol Biosynthetic Process Sterol Biosynthetic Process Nitrate Transmembrane Transporter Activity Chloride Transmembrane Transport Odontogenesis Chloride Transport Steroid Biosynthetic Process Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Delta7-sterol 5(6)-desaturase Activity Negative Regulation Of Vasculogenesis Positive Regulation Of ERBB3 Signaling Pathway Cell Adhesion Involved In Sprouting Angiogenesis Inorganic Anion Transmembrane Transport Cholesterol Metabolic Process Sterol Metabolic Process PH-gated Chloride Channel Activity Nitrate Transmembrane Transport Monoatomic Anion Transmembrane Transport Inorganic Anion Transport Monoatomic Anion Transport Positive Regulation Of Anion Channel Activity C-5 Sterol Desaturase Activity Positive Regulation Of Monoatomic Anion Transport Cholesterol Biosynthetic Process Via Lathosterol Cholesterol Biosynthetic Process Via Desmosterol Positive Regulation Of Protein Localization To Endoplasmic Reticulum Endoplasmic Reticulum Membrane Positive Regulation Of Enamel Mineralization Cell Migration Involved In Vasculogenesis Carbon Dioxide Transmembrane Transporter Activity Carbon Dioxide Transmembrane Transport Transepithelial Water Transport Steroid Metabolic Process Regulation Of Branching Morphogenesis Of A Nerve Intracellular Sphingolipid Homeostasis Central Nervous System Vasculogenesis Endoplasmic Reticulum Tubular Network Membrane Positive Regulation Of Tooth Mineralization Positive Regulation Of Mammary Gland Epithelial Cell Proliferation Positive Regulation Of Toll-like Receptor 9 Signaling Pathway Endoplasmic Reticulum Tubular Network Formation Alcohol Metabolic Process Chloride Channel Inhibitor Activity Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Membrane Hyperpolarization
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