SC5D and SCN4B

		SC5D	SCN4B
Description		sterol-C5-desaturase	sodium voltage-gated channel beta subunit 4
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane	Voltage-gated Sodium Channel Complex Plasma Membrane Intercalated Disc Membrane
	Molecular Function	C-5 Sterol Desaturase Activity Iron Ion Binding Oxidoreductase Activity Delta7-sterol 5(6)-desaturase Activity	Voltage-gated Sodium Channel Activity Protein Binding Sodium Channel Regulator Activity Transmembrane Transporter Binding Voltage-gated Sodium Channel Activity Involved In Cardiac Muscle Cell Action Potential
	Biological Process	Lipid Metabolic Process Steroid Biosynthetic Process Cholesterol Biosynthetic Process Steroid Metabolic Process Lipid Biosynthetic Process Sterol Biosynthetic Process Cholesterol Biosynthetic Process Via Desmosterol Cholesterol Biosynthetic Process Via Lathosterol Negative Regulation Of Ferroptosis	Monoatomic Ion Transport Sodium Ion Transport Positive Regulation Of Sodium Ion Transport Neuronal Action Potential Sodium Ion Transmembrane Transport Establishment Of Localization In Cell Cardiac Muscle Contraction Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Cardiac Conduction Cardiac Muscle Cell Action Potential Involved In Contraction Membrane Depolarization During Cardiac Muscle Cell Action Potential AV Node Cell Action Potential Regulation Of Heart Rate By Cardiac Conduction
Pathways		Activation of gene expression by SREBF (SREBP) Cholesterol biosynthesis via desmosterol Cholesterol biosynthesis via lathosterol	Interaction between L1 and Ankyrins Phase 0 - rapid depolarisation Sensory perception of sweet, bitter, and umami (glutamate) taste
Drugs			Ranolazine Valproic acid Oxcarbazepine Cocaine Zonisamide Brivaracetam Dichlorobenzyl alcohol Fish oil
Diseases			Long QT syndrome, including: Romano-Ward syndrome; Jervell and Lange-Nielsen syndrome (JLNS)
GWAS
Interacting Genes		7 interacting genes: CGREF1 FRMD5 RPS25 SCN4B SLC19A2 UBE4A VGLL1	3 interacting genes: SC5D SCN2A YIF1A
Entrez ID		6309	6330
HPRD ID		09078	09749
Ensembl ID		ENSG00000109929	ENSG00000177098
Uniprot IDs		O75845	B0YJ93 Q8IWT1
PDB IDs			4MZ2 4MZ3 5XAW 6VSV 7DTD
Enriched GO Terms of Interacting Partners?		Voltage-gated Sodium Channel Activity Involved In Cardiac Muscle Cell Action Potential AV Node Cell Action Potential Pyridoxine Transport Thiamine Transmembrane Transporter Activity Thiamine Transport Folic Acid Transmembrane Transporter Activity Thiamine Diphosphate Metabolic Process Thiamine Diphosphate Biosynthetic Process Thiamine Transmembrane Transport Vitamin Transmembrane Transporter Activity Thiamine-containing Compound Metabolic Process Folic Acid Transport	Cholesterol Biosynthetic Process Via Lathosterol Cholesterol Biosynthetic Process Via Desmosterol C-5 Sterol Desaturase Activity Delta7-sterol 5(6)-desaturase Activity Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress Regulation Of Ferroptosis Negative Regulation Of Ferroptosis Voltage-gated Sodium Channel Complex Voltage-gated Sodium Channel Activity Node Of Ranvier Cholesterol Biosynthetic Process Sodium Channel Activity Neuronal Action Potential Cardiac Muscle Cell Action Potential Involved In Contraction Monoatomic Cation Channel Activity COPII-coated ER To Golgi Transport Vesicle Sterol Biosynthetic Process Cardiac Muscle Cell Action Potential
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