SC5D and SLC19A2

Number of citations of the paper that reports this interaction (PubMedID 40355756)
172

Data Source:
BioGRID (affinity chromatography technology)

		SC5D	SLC19A2
Description		sterol-C5-desaturase	solute carrier family 19 member 2
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane	Plasma Membrane Membrane
	Molecular Function	C-5 Sterol Desaturase Activity Iron Ion Binding Oxidoreductase Activity Delta7-sterol 5(6)-desaturase Activity	Protein Binding Folic Acid Transmembrane Transporter Activity Thiamine Transmembrane Transporter Activity Vitamin Transmembrane Transporter Activity
	Biological Process	Lipid Metabolic Process Steroid Biosynthetic Process Cholesterol Biosynthetic Process Steroid Metabolic Process Lipid Biosynthetic Process Sterol Biosynthetic Process Cholesterol Biosynthetic Process Via Desmosterol Cholesterol Biosynthetic Process Via Lathosterol Negative Regulation Of Ferroptosis	Spermatogenesis Thiamine Diphosphate Biosynthetic Process Folic Acid Transport Thiamine Transport Pyridoxine Transport Thiamine-containing Compound Metabolic Process Vitamin Transport Transmembrane Transport Thiamine Transmembrane Transport
Pathways		Activation of gene expression by SREBF (SREBP) Cholesterol biosynthesis via desmosterol Cholesterol biosynthesis via lathosterol	Vitamin B1 (thiamin) metabolism
Drugs
Diseases
GWAS			Plasma factor V levels in venous thrombosis ( 31271701) Venous thromboembolism ( 21980494)
Interacting Genes		7 interacting genes: CGREF1 FRMD5 RPS25 SCN4B SLC19A2 UBE4A VGLL1	3 interacting genes: CERS2 DEDD SC5D
Entrez ID		6309	10560
HPRD ID		09078	04897
Ensembl ID		ENSG00000109929	ENSG00000117479
Uniprot IDs		O75845	A0A024R8Y5 A0A024R928 O60779
PDB IDs			8Z7Z 8Z80
Enriched GO Terms of Interacting Partners?		Voltage-gated Sodium Channel Activity Involved In Cardiac Muscle Cell Action Potential AV Node Cell Action Potential Pyridoxine Transport Thiamine Transmembrane Transporter Activity Thiamine Transport Folic Acid Transmembrane Transporter Activity Thiamine Diphosphate Metabolic Process Thiamine Diphosphate Biosynthetic Process Thiamine Transmembrane Transport Vitamin Transmembrane Transporter Activity Thiamine-containing Compound Metabolic Process Folic Acid Transport	Cholesterol Biosynthetic Process Via Lathosterol Cholesterol Biosynthetic Process Via Desmosterol C-5 Sterol Desaturase Activity Delta7-sterol 5(6)-desaturase Activity Negative Regulation Of Schwann Cell Proliferation Involved In Axon Regeneration Negative Regulation Of Schwann Cell Migration Negative Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I Sphingosine N-acyltransferase Activity Negative Regulation Of Glial Cell Migration Negative Regulation Of Schwann Cell Proliferation N-acyltransferase Activity Negative Regulation Of Transcription By RNA Polymerase I Negative Regulation Of Ferroptosis Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I Negative Regulation Of Axon Regeneration Negative Regulation Of Neuron Projection Regeneration Regulation Of Ferroptosis Lipid Biosynthetic Process Negative Regulation Of Glial Cell Proliferation Regulation Of Glial Cell Migration Response To Immobilization Stress Decidualization Regulation Of Axon Regeneration Regulation Of Neuron Projection Regeneration Cholesterol Biosynthetic Process Sterol Biosynthetic Process Regulation Of Transcription By RNA Polymerase I Regulation Of Glial Cell Proliferation Negative Regulation Of Gliogenesis Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Ceramide Biosynthetic Process Endoplasmic Reticulum Membrane Lipid Metabolic Process
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