SC5D and FRMD5

		SC5D	FRMD5
Description		sterol-C5-desaturase	FERM domain containing 5
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane	Cytoskeleton Adherens Junction Membrane Anchoring Junction
	Molecular Function	C-5 Sterol Desaturase Activity Iron Ion Binding Oxidoreductase Activity Delta7-sterol 5(6)-desaturase Activity	Integrin Binding Protein Binding Cytoskeletal Protein Binding Protein Kinase Binding
	Biological Process	Lipid Metabolic Process Steroid Biosynthetic Process Cholesterol Biosynthetic Process Steroid Metabolic Process Lipid Biosynthetic Process Sterol Biosynthetic Process Cholesterol Biosynthetic Process Via Desmosterol Cholesterol Biosynthetic Process Via Lathosterol Negative Regulation Of Ferroptosis	Regulation Of Cell Migration Actomyosin Structure Organization Positive Regulation Of Cell Adhesion Negative Regulation Of Cell Motility
Pathways		Activation of gene expression by SREBF (SREBP) Cholesterol biosynthesis via desmosterol Cholesterol biosynthesis via lathosterol
Drugs
Diseases
GWAS			Appendicular lean mass ( 33097823) Hemoglobin levels ( 32327693) Lipoprotein phospholipase A2 activity in cardiovascular disease ( 28753643) Serum albumin levels ( 23022100) Serum alkaline phosphatase levels ( 33547301) Triglyceride levels ( 28334899) Triglycerides ( 20686565 24097068 25961943) Urinary tract infection frequency ( 28928442) Uterine fibroid number (single vs multiple) ( 30196971)
Interacting Genes		7 interacting genes: CGREF1 FRMD5 RPS25 SCN4B SLC19A2 UBE4A VGLL1	3 interacting genes: CEP250 NELFCD SC5D
Entrez ID		6309	84978
HPRD ID		09078	17493
Ensembl ID		ENSG00000109929	ENSG00000171877
Uniprot IDs		O75845	A0A087WVP2 A8K1U8 B3KVN9 B5MC67 H0YKW6 Q7Z6J6
PDB IDs
Enriched GO Terms of Interacting Partners?		Voltage-gated Sodium Channel Activity Involved In Cardiac Muscle Cell Action Potential AV Node Cell Action Potential Pyridoxine Transport Thiamine Transmembrane Transporter Activity Thiamine Transport Folic Acid Transmembrane Transporter Activity Thiamine Diphosphate Metabolic Process Thiamine Diphosphate Biosynthetic Process Thiamine Transmembrane Transport Vitamin Transmembrane Transporter Activity Thiamine-containing Compound Metabolic Process Folic Acid Transport	Cholesterol Biosynthetic Process Via Lathosterol Cholesterol Biosynthetic Process Via Desmosterol C-5 Sterol Desaturase Activity Delta7-sterol 5(6)-desaturase Activity Regulation Of Centriole-centriole Cohesion NELF Complex Positive Regulation Of Protein Localization To Centrosome Regulation Of Ferroptosis Negative Regulation Of Ferroptosis Spindle Pole Centrosome Centriole-centriole Cohesion Regulation Of Protein Localization To Centrosome Detection Of Light Stimulus Involved In Visual Perception Protein Localization To Centrosome Negative Regulation Of DNA-templated Transcription, Elongation Negative Regulation Of Transcription Elongation By RNA Polymerase II Cholesterol Biosynthetic Process Sterol Biosynthetic Process Protein Localization To Cytoskeleton Non-motile Cilium Assembly Photoreceptor Inner Segment Detection Of Light Stimulus
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