FRMD5 and SC5D

		FRMD5	SC5D
Description		FERM domain containing 5	sterol-C5-desaturase
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoskeleton Adherens Junction Membrane Anchoring Junction	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Integrin Binding Protein Binding Cytoskeletal Protein Binding Protein Kinase Binding	C-5 Sterol Desaturase Activity Iron Ion Binding Oxidoreductase Activity Delta7-sterol 5(6)-desaturase Activity
	Biological Process	Regulation Of Cell Migration Actomyosin Structure Organization Positive Regulation Of Cell Adhesion Negative Regulation Of Cell Motility	Lipid Metabolic Process Steroid Biosynthetic Process Cholesterol Biosynthetic Process Steroid Metabolic Process Lipid Biosynthetic Process Sterol Biosynthetic Process Cholesterol Biosynthetic Process Via Desmosterol Cholesterol Biosynthetic Process Via Lathosterol Negative Regulation Of Ferroptosis
Pathways			Activation of gene expression by SREBF (SREBP) Cholesterol biosynthesis via desmosterol Cholesterol biosynthesis via lathosterol
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Hemoglobin levels ( 32327693) Lipoprotein phospholipase A2 activity in cardiovascular disease ( 28753643) Serum albumin levels ( 23022100) Serum alkaline phosphatase levels ( 33547301) Triglyceride levels ( 28334899) Triglycerides ( 20686565 24097068 25961943) Urinary tract infection frequency ( 28928442) Uterine fibroid number (single vs multiple) ( 30196971)
Interacting Genes		3 interacting genes: CEP250 NELFCD SC5D	7 interacting genes: CGREF1 FRMD5 RPS25 SCN4B SLC19A2 UBE4A VGLL1
Entrez ID		84978	6309
HPRD ID		17493	09078
Ensembl ID		ENSG00000171877	ENSG00000109929
Uniprot IDs		A0A087WVP2 A8K1U8 B3KVN9 B5MC67 H0YKW6 Q7Z6J6	O75845
PDB IDs
Enriched GO Terms of Interacting Partners?		Cholesterol Biosynthetic Process Via Lathosterol Cholesterol Biosynthetic Process Via Desmosterol C-5 Sterol Desaturase Activity Delta7-sterol 5(6)-desaturase Activity Regulation Of Centriole-centriole Cohesion NELF Complex Positive Regulation Of Protein Localization To Centrosome Regulation Of Ferroptosis Negative Regulation Of Ferroptosis Spindle Pole Centrosome Centriole-centriole Cohesion Regulation Of Protein Localization To Centrosome Detection Of Light Stimulus Involved In Visual Perception Protein Localization To Centrosome Negative Regulation Of DNA-templated Transcription, Elongation Negative Regulation Of Transcription Elongation By RNA Polymerase II Cholesterol Biosynthetic Process Sterol Biosynthetic Process Protein Localization To Cytoskeleton Non-motile Cilium Assembly Photoreceptor Inner Segment Detection Of Light Stimulus	Voltage-gated Sodium Channel Activity Involved In Cardiac Muscle Cell Action Potential AV Node Cell Action Potential Pyridoxine Transport Thiamine Transmembrane Transporter Activity Thiamine Transport Folic Acid Transmembrane Transporter Activity Thiamine Diphosphate Metabolic Process Thiamine Diphosphate Biosynthetic Process Thiamine Transmembrane Transport Vitamin Transmembrane Transporter Activity Thiamine-containing Compound Metabolic Process Folic Acid Transport
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