CUL4A and SKP2

Number of citations of the paper that reports this interaction (PubMedID 16537899)
48

Data Source:
HPRD (in vitro)

		CUL4A	SKP2
Description		cullin 4A	S-phase kinase associated protein 2
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cullin-RING Ubiquitin Ligase Complex Cul4A-RING E3 Ubiquitin Ligase Complex Cul4-RING E3 Ubiquitin Ligase Complex	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol SCF Ubiquitin Ligase Complex
	Molecular Function	Protein Binding Ubiquitin Protein Ligase Binding Ubiquitin Protein Ligase Activity Ubiquitin Ligase Complex Scaffold Activity	Protein Binding Identical Protein Binding Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process	G1/S Transition Of Mitotic Cell Cycle In Utero Embryonic Development DNA Repair Ubiquitin-dependent Protein Catabolic Process DNA Damage Response Spermatogenesis Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Protein Ubiquitination Hemopoiesis Negative Regulation Of Granulocyte Differentiation Developmental Process Cellular Response To UV Somatic Stem Cell Population Maintenance MiRNA-mediated Gene Silencing By MRNA Destabilization T Cell Activation Ribosome Biogenesis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Rhythmic Process Regulation Of Protein Metabolic Process Type I Interferon-mediated Signaling Pathway Intrinsic Apoptotic Signaling Pathway Base-excision Repair, AP Site Formation Via Deaminated Base Removal Ubiquitin-dependent Protein Catabolic Process Via The C-end Degron Rule Pathway Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of DNA Damage Checkpoint Regulation Of Nucleotide-excision Repair	G1/S Transition Of Mitotic Cell Cycle G2/M Transition Of Mitotic Cell Cycle Protein Polyubiquitination DNA Double-strand Break Processing Immune System Process Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Innate Immune Response Positive Regulation Of Smooth Muscle Cell Proliferation Defense Response To Virus Regulation Of Cell Cycle Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Cellular Response To Cell-matrix Adhesion Positive Regulation Of Protein Polyubiquitination Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Protein Localization To Site Of Double-strand Break
Pathways		Recognition of DNA damage by PCNA-containing replication complex DNA Damage Recognition in GG-NER Formation of Incision Complex in GG-NER Dual Incision in GG-NER Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Neddylation	APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 SCF(Skp2)-mediated degradation of p27/p21 Ub-specific processing proteases Orc1 removal from chromatin Cyclin D associated events in G1 Regulation of RUNX2 expression and activity Neddylation Aberrant regulation of mitotic exit in cancer due to RB1 defects Regulation of BACH1 activity Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Atrial fibrillation ( 30061737) Bipolar disorder ( 31043756 34002096) HDL cholesterol levels ( 32203549) Immature fraction of reticulocytes ( 32888494) Intracranial aneurysm ( 30823506) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean platelet volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Platelet distribution width ( 27863252 32888494) Red cell distribution width ( 32888494)	Appendicular lean mass ( 33097823) Birth weight ( 31043758) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483) Red cell distribution width ( 27863252 32888494)
Interacting Genes		26 interacting genes: CAND1 CDKN1B CENPA CHEK1 COMMD1 COPS2 DCUN1D4 DDB1 DDB2 H1-2 H3C1 HOXA9 IRS2 LNCAROD PAFAH1B1 RBX1 SALL2 SENP8 SKP2 ST7 TP53 TUBG1 UBC UBE2D1 UBE2E3 UBE2M	68 interacting genes: ACE2 AKT1 BRAP BRCA1 BTG1 BTG2 CCNA2 CCNE1 CCNT1 CDC14B CDC34 CDK2 CDK9 CDKN1B CDKN1C CDT1 CEBPA CFLAR CHKA CKS1B CKS1BP7 CUL1 CUL4A DDB1 DUSP1 E2F1 ELF4 ESR1 FZR1 GPS1 KPNA1 KPNA6 MEF2D MTOR MYB MYBL2 MYC NHERF1 NLK NUDT1 ORC1 PAX8 PDCD4 PFDN1 PIM1 POLR1A POLR2A PSMD9 PTK2 RAG2 RB1 RBL2 RND3 SIRT4 SIRT6 SKP1 SMAD4 SQSTM1 STK11 TAL1 TCF3 TLE5 TRIM21 UBB VHL WEE1 YWHAB YY1
Entrez ID		8451	6502
HPRD ID		07218	03256
Ensembl ID		ENSG00000139842	ENSG00000145604
Uniprot IDs		A0A087WWN2 A0A0A0MR50 Q13619	Q13309
PDB IDs		2HYE 4A0K 7OKQ 7OPC 7OPD 8B3G 8B3I	1FQV 1FS1 1FS2 1LDK 2ASS 2AST 7B5L 7B5M 7B5R 7LUO 7Z8T 7Z8V 7ZBW 7ZBZ 8BYA 8BYL 8CDJ 8CDK 8OR0 8OR3 8OR4
Enriched GO Terms of Interacting Partners?		Post-translational Protein Modification Protein Modification By Small Protein Conjugation Cul4A-RING E3 Ubiquitin Ligase Complex Nucleotide-excision Repair Protein Neddylation Cul4B-RING E3 Ubiquitin Ligase Complex Protein Modification Process Nucleus Positive Regulation Of Post-translational Protein Modification Regulation Of Post-translational Protein Modification Protein Ubiquitination Nucleoplasm Cullin Family Protein Binding Cellular Response To UV Cul4-RING E3 Ubiquitin Ligase Complex Base-excision Repair, AP Site Formation Via Deaminated Base Removal Cellular Response To Light Stimulus Protein K48-linked Ubiquitination Positive Regulation Of Protein Ubiquitination Positive Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly NEDD8 Transferase Activity Regulation Of Protein Modification Process Ubiquitin-protein Transferase Activity DNA Damage Response, Signal Transduction By P53 Class Mediator Epigenetic Regulation Of Gene Expression Protein Polyubiquitination Mitotic Cell Cycle Phase Transition Signal Transduction In Response To DNA Damage Regulation Of Mitotic Cell Cycle DNA Metabolic Process Macromolecule Metabolic Process Response To UV Cellular Response To Antibiotic Cell Cycle Phase Transition DNA Repair Protein-containing Complex Protein Metabolic Process UV-damage Excision Repair Cellular Response To Radiation Protein Deneddylation DNA Damage Response Negative Regulation Of Mitophagy Chromosome Organization Positive Regulation Of Protein Metabolic Process Interferon-mediated Signaling Pathway Protein-containing Complex Binding Regulation Of Protein Ubiquitination Nuclear Membrane Disassembly Inner Cell Mass Cell Proliferation Replicative Senescence	Nucleoplasm Regulation Of Primary Metabolic Process Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Mitotic Cell Cycle Nucleus Regulation Of Cell Cycle Positive Regulation Of Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Population Proliferation Positive Regulation Of RNA Metabolic Process Cellular Response To Stress Regulation Of Cell Cycle Phase Transition Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Apoptotic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Programmed Cell Death Regulation Of RNA Metabolic Process Negative Regulation Of Metabolic Process Nucleic Acid Metabolic Process G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Nucleobase-containing Compound Metabolic Process Cell Cycle G1/S Phase Transition Regulation Of Protein Metabolic Process Negative Regulation Of Cell Cycle DNA-templated Transcription Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Mitotic Cell Cycle Phase Transition Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Cell Cycle Process Cell Cycle Phase Transition Intracellular Signal Transduction Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Protein Modification Process Positive Regulation Of Biosynthetic Process Cell Population Proliferation Regulation Of Protein Modification Process Regulation Of Cell Differentiation
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