NLK and FOXO4

Number of citations of the paper that reports this interaction (PubMedID 20874444)
0

Data Source:
BioGRID (enzymatic study)

		NLK	FOXO4
Description		nemo like kinase	forkhead box O4
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Speck
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Ubiquitin Protein Ligase Binding SH2 Domain Binding Metal Ion Binding Protein Serine Kinase Activity DNA-binding Transcription Factor Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Nucleic Acid Binding DNA Binding DNA-binding Transcription Factor Activity Protein Binding Beta-catenin Binding Enzyme Binding Identical Protein Binding Sequence-specific DNA Binding DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding Promoter-specific Chromatin Binding
	Biological Process	MAPK Cascade Regulation Of DNA-templated Transcription Protein Phosphorylation Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Wnt Signaling Pathway, Calcium Modulating Pathway Regulation Of Signal Transduction Wnt Signaling Pathway Peptidyl-threonine Phosphorylation Negative Regulation Of Wnt Signaling Pathway Cellular Response To Nutrient Levels Cellular Response To Stress Intracellular Signal Transduction TORC1 Signaling Protein Stabilization Protein Localization To Lysosome Cellular Response To Osmotic Stress Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling Positive Regulation Of Receptor Signaling Pathway Via STAT	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Response To Oxidative Stress Mitotic G2 DNA Damage Checkpoint Signaling Muscle Organ Development Negative Regulation Of Cell Population Proliferation Insulin Receptor Signaling Pathway Positive Regulation Of Smooth Muscle Cell Migration Negative Regulation Of Angiogenesis Cell Differentiation Response To Nutrient Levels Cellular Response To Oxidative Stress Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Stem Cell Differentiation Negative Regulation Of Smooth Muscle Cell Differentiation Negative Regulation Of G0 To G1 Transition Protein K48-linked Ubiquitination Response To Water-immersion Restraint Stress
Pathways		Ca2+ pathway	AKT phosphorylates targets in the nucleus Constitutive Signaling by AKT1 E17K in Cancer Ub-specific processing proteases Regulation of localization of FOXO transcription factors FOXO-mediated transcription of cell death genes FOXO-mediated transcription of cell death genes FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes Regulation of FOXO transcriptional activity by acetylation FOXO-mediated transcription of cell cycle genes FOXO-mediated transcription of cell cycle genes Cardiogenesis
Drugs
Diseases
GWAS		Non-response to bupropion and depression ( 27622933)
Interacting Genes		27 interacting genes: ASGR1 ATXN1 CREBBP CUL1 FBXW5 FOXO4 FOXP3 GRN HIPK2 KRTAP10-1 KRTAP10-3 KRTAP4-2 KRTAP5-6 KRTAP5-9 LEF1 MYB MYBL1 NDOR1 NOTCH1 QRICH1 RCHY1 RPTOR SDR16C5 SKP2 STAT3 USP4 ZHX3	16 interacting genes: AKT1 AKT2 CREBBP CTNNB1 ESR1 FOXG1 NLK PIN1 REL SFN SMAD3 SMAD4 TAF1 TP53 XPO1 YWHAZ
Entrez ID		51701	4303
HPRD ID		17637	02070
Ensembl ID		ENSG00000087095	ENSG00000184481
Uniprot IDs		Q9UBE8	P98177
PDB IDs			1E17 3L2C
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Cell Population Proliferation Cell Population Proliferation Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription Intermediate Filament Response To Hypoxia Response To Decreased Oxygen Levels Positive Regulation Of RNA Metabolic Process Response To Oxygen Levels Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Metabolic Process Regulation Of Cell Population Proliferation Positive Regulation Of Developmental Process T-helper 17 Type Immune Response Regulation Of Cell Development Negative Regulation Of RNA Metabolic Process Regulation Of Multicellular Organismal Development Cytosol Regulation Of Glial Cell Proliferation Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of Cell Development Positive Regulation Of Cell Differentiation Negative Regulation Of Interleukin-4 Production Positive Regulation Of Odontoblast Differentiation RNA Polymerase II Transcription Regulator Complex Nucleoplasm Negative Regulation Of Nucleobase-containing Compound Metabolic Process CD4-positive, Alpha-beta T Cell Differentiation Negative Regulation Of Interleukin-5 Production Positive Regulation Of Neuroepithelial Cell Differentiation Positive Regulation Of Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of Cell Differentiation Regulation Of DNA-templated Transcription Cellular Response To Stress Regulation Of RNA Biosynthetic Process Transcription By RNA Polymerase II Leukocyte Activation Involved In Immune Response Cell Activation Involved In Immune Response SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Odontoblast Differentiation	Intracellular Signaling Cassette Intracellular Signal Transduction Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Protein Stability Negative Regulation Of Metabolic Process Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process Protein Stabilization Transcription Coactivator Binding Transcription Regulator Complex Regulation Of Macromolecule Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Primary Metabolic Process Nucleoplasm Negative Regulation Of Intracellular Signal Transduction Regulation Of Intracellular Signal Transduction DNA-binding Transcription Factor Binding Regulation Of Macromolecule Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Phosphoserine Residue Binding Cellular Response To Oxygen-containing Compound Negative Regulation Of Protein Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Protein Localization Regulation Of Metabolic Process Regulation Of Signal Transduction Negative Regulation Of Signal Transduction Cell Population Proliferation Regulation Of Cell Cycle Gastrulation Transcription Corepressor Binding Negative Regulation Of Signaling Negative Regulation Of Cell Communication Nucleus Regulation Of Protein Metabolic Process Response To Decreased Oxygen Levels Positive Regulation Of Signal Transduction Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Protein Localization To Nucleus Regulation Of Signaling
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?