SIRT4

Description		sirtuin 4
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix
	Molecular Function	NAD+ Poly-ADP-ribosyltransferase Activity Histone Deacetylase Activity Protein Binding Zinc Ion Binding Transferase Activity Acyltransferase Activity, Transferring Groups Other Than Amino-acyl Groups Glycosyltransferase Activity Nucleotidyltransferase Activity NAD-dependent Protein Lysine Deacetylase Activity Metal Ion Binding NAD Binding Lipoamidase Activity NAD+ Binding NAD-dependent Protein Lipoamidase Activity NAD-dependent Protein Biotinidase Activity NAD+-protein-cysteine ADP-ribosyltransferase Activity NAD+-protein Mono-ADP-ribosyltransferase Activity
	Biological Process	Regulation Of Glutamine Family Amino Acid Metabolic Process Glutamine Metabolic Process DNA Damage Response Mitochondrion Organization Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Peptidyl-lysine Deacetylation Negative Regulation Of Fatty Acid Oxidation Negative Regulation Of Insulin Secretion Positive Regulation Of Lipid Biosynthetic Process Cellular Response To Hypoxia Tricarboxylic Acid Metabolic Process Negative Regulation Of Pyruvate Decarboxylation To Acetyl-CoA Negative Regulation Of Protein Processing Involved In Protein Targeting To Mitochondrion
Pathways		Regulation of pyruvate dehydrogenase (PDH) complex Transcriptional activation of mitochondrial biogenesis
Drugs
Diseases
GWAS		Bipolar disorder ( 31043756)
Novel Interacting Genes		2 novel interacting genes: PTEN SKP2
Interacting Genes		2 interacting genes: PTEN SKP2
Entrez ID		23409
HPRD ID		06837
Ensembl ID		ENSG00000089163
Uniprot IDs		Q9Y6E7
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Synaptic Vesicle Clustering Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Regulation Of Smooth Muscle Cell Proliferation Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity Central Nervous System Myelin Maintenance Rhythmic Synaptic Transmission Locomotor Rhythm Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase Activity Myelin Sheath Adaxonal Region Phosphatidylinositol-3-phosphate Phosphatase Activity Cellular Response To Electrical Stimulus Ubiquitin Ligase Activator Activity Regulation Of Protein Modification Process Spindle Assembly Involved In Female Meiosis Negative Regulation Of Peptidyl-serine Phosphorylation Regulation Of Synaptic Vesicle Clustering Postsynaptic Specialization Assembly Negative Regulation Of Wound Healing, Spreading Of Epidermal Cells Prepulse Inhibition Neuron-neuron Synaptic Transmission Phosphatidylinositol Phosphate Phosphatase Activity Meiotic Spindle Assembly Negative Regulation Of Cell Size Maternal Behavior Presynaptic Membrane Organization Schmidt-Lanterman Incisure Myelin Maintenance Anaphase-promoting Complex Binding Postsynaptic Density Assembly Forebrain Morphogenesis Negative Regulation Of Excitatory Postsynaptic Potential Presynaptic Membrane Assembly Parental Behavior Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Cellular Response To Cell-matrix Adhesion Synapse Maturation Negative Regulation Of Epithelial Cell Migration Postsynaptic Density Organization Positive Regulation Of Protein Metabolic Process Negative Regulation Of Focal Adhesion Assembly Dendritic Spine Morphogenesis Ubiquitin-specific Protease Binding Positive Regulation Of Protein Polyubiquitination Circadian Behavior Positive Regulation Of Cell Population Proliferation Phosphatidylinositol Dephosphorylation Meiotic Spindle Organization Rhythmic Behavior
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