SLC19A2 and SC5D

Number of citations of the paper that reports this interaction (PubMedID 40355756)
172

Data Source:
BioGRID (affinity chromatography technology)

		SLC19A2	SC5D
Description		solute carrier family 19 member 2	sterol-C5-desaturase
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Protein Binding Folic Acid Transmembrane Transporter Activity Thiamine Transmembrane Transporter Activity Vitamin Transmembrane Transporter Activity	C-5 Sterol Desaturase Activity Iron Ion Binding Oxidoreductase Activity Delta7-sterol 5(6)-desaturase Activity
	Biological Process	Spermatogenesis Thiamine Diphosphate Biosynthetic Process Folic Acid Transport Thiamine Transport Pyridoxine Transport Thiamine-containing Compound Metabolic Process Vitamin Transport Transmembrane Transport Thiamine Transmembrane Transport	Lipid Metabolic Process Steroid Biosynthetic Process Cholesterol Biosynthetic Process Steroid Metabolic Process Lipid Biosynthetic Process Sterol Biosynthetic Process Cholesterol Biosynthetic Process Via Desmosterol Cholesterol Biosynthetic Process Via Lathosterol Negative Regulation Of Ferroptosis
Pathways		Vitamin B1 (thiamin) metabolism	Activation of gene expression by SREBF (SREBP) Cholesterol biosynthesis via desmosterol Cholesterol biosynthesis via lathosterol
Drugs
Diseases
GWAS		Plasma factor V levels in venous thrombosis ( 31271701) Venous thromboembolism ( 21980494)
Interacting Genes		3 interacting genes: CERS2 DEDD SC5D	7 interacting genes: CGREF1 FRMD5 RPS25 SCN4B SLC19A2 UBE4A VGLL1
Entrez ID		10560	6309
HPRD ID		04897	09078
Ensembl ID		ENSG00000117479	ENSG00000109929
Uniprot IDs		A0A024R8Y5 A0A024R928 O60779	O75845
PDB IDs		8Z7Z 8Z80
Enriched GO Terms of Interacting Partners?		Cholesterol Biosynthetic Process Via Lathosterol Cholesterol Biosynthetic Process Via Desmosterol C-5 Sterol Desaturase Activity Delta7-sterol 5(6)-desaturase Activity Negative Regulation Of Schwann Cell Proliferation Involved In Axon Regeneration Negative Regulation Of Schwann Cell Migration Negative Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I Sphingosine N-acyltransferase Activity Negative Regulation Of Glial Cell Migration Negative Regulation Of Schwann Cell Proliferation N-acyltransferase Activity Negative Regulation Of Transcription By RNA Polymerase I Negative Regulation Of Ferroptosis Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I Negative Regulation Of Axon Regeneration Negative Regulation Of Neuron Projection Regeneration Regulation Of Ferroptosis Lipid Biosynthetic Process Negative Regulation Of Glial Cell Proliferation Regulation Of Glial Cell Migration Response To Immobilization Stress Decidualization Regulation Of Axon Regeneration Regulation Of Neuron Projection Regeneration Cholesterol Biosynthetic Process Sterol Biosynthetic Process Regulation Of Transcription By RNA Polymerase I Regulation Of Glial Cell Proliferation Negative Regulation Of Gliogenesis Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Ceramide Biosynthetic Process Endoplasmic Reticulum Membrane Lipid Metabolic Process	Voltage-gated Sodium Channel Activity Involved In Cardiac Muscle Cell Action Potential AV Node Cell Action Potential Pyridoxine Transport Thiamine Transmembrane Transporter Activity Thiamine Transport Folic Acid Transmembrane Transporter Activity Thiamine Diphosphate Metabolic Process Thiamine Diphosphate Biosynthetic Process Thiamine Transmembrane Transport Vitamin Transmembrane Transporter Activity Thiamine-containing Compound Metabolic Process Folic Acid Transport
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