ROR2 and MTMR1

Number of citations of the paper that reports this interaction (PubMedID 28065597)
51

Data Source:
BioGRID (two hybrid)

		ROR2	MTMR1
Description		receptor tyrosine kinase like orphan receptor 2	myotubularin related protein 1
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GO Annotations	Cellular Component	Plasma Membrane Membrane Axon Clathrin-coated Endocytic Vesicle Membrane Receptor Complex	Cytoplasm Cytosol Plasma Membrane Membrane
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Binding ATP Binding Coreceptor Activity Kinase Activity Transferase Activity Wnt-protein Binding Mitogen-activated Protein Kinase Kinase Kinase Binding Metal Ion Binding	Phosphatidylinositol-3-phosphate Phosphatase Activity Hydrolase Activity Protein Homodimerization Activity Phosphatidylinositol-3,5-bisphosphate 3-phosphatase Activity Phosphatidylinositol Phosphate Phosphatase Activity
	Biological Process	Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Wnt Signaling Pathway Positive Regulation Of Cell Migration	Lipid Metabolic Process Phosphatidylinositol Biosynthetic Process Protein Destabilization Phosphatidylinositol Dephosphorylation Regulation Of Phosphatidylinositol Dephosphorylation
Pathways		PCP/CE pathway WNT5A-dependent internalization of FZD2, FZD5 and ROR2	Synthesis of PIPs at the plasma membrane RHOF GTPase cycle
Drugs
Diseases		Robinow syndrome Brachydactyly, including: type A; type B; type D; type E
GWAS		Bipolar disorder (inflammation and infection response interaction) ( 25781172) Bipolar disorder and schizophrenia ( 22688191) Birth weight ( 31043758) Bone mineral density (hip) ( 26911590) Facial morphology ( 31763980) Iris color (L* coordinate) ( 30895295) Nose size ( 27182965) Offspring birth weight ( 31043758) Serum immune biomarker levels ( 32066700) Type 2 diabetes ( 25483131)	Mean platelet volume ( 32888494)
Interacting Genes		73 interacting genes: ACTMAP ALG13 ARID5A ATXN7L1 BHLHE40 C10orf55 C1orf94 CDC14A CDC25C CREM CRX DAB1 DAZAP2 DUSP1 DUSP10 DUSP14 DUSP18 DUSP19 DUSP21 DUSP29 DUSP6 ERBB2 EYA2 FAM168B FOSB FZD2 FZD5 HIVEP1 IKBKG ILKAP ISX KRTAP19-7 KRTAP6-2 KRTAP7-1 LHX6 MAGED1 MAP3K7 MTMR1 MTMR2 MTMR6 MTMR9 PITX1 PLA2G10 POU2AF1 PPM1A PPM1B PPM1F PPP3CB PRKAB2 PRR20A PRR20B PRR20C PRR20D PRR20E PRR23E PTPN11 PTPN12 PTPN20 PTPN6 PTPN7 PTPRR RBPMS SOX14 STOX1 STYX TAB1 TENT5A TLX3 TPTE VENTX WNT5A ZMYM4 ZNF34	3 interacting genes: ERBB3 PTK7 ROR2
Entrez ID		4920	8776
HPRD ID		03822	02163
Ensembl ID		ENSG00000169071	ENSG00000063601
Uniprot IDs		Q01974	B7Z3D5 E9PPP8 F8WA39 Q13613 Q8NEC6
PDB IDs		3ZZW 4GT4 6OSH 6OSN 6OSV 9FSE	5C16
Enriched GO Terms of Interacting Partners?		Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Dephosphorylation Protein Serine/threonine Phosphatase Activity Protein Dephosphorylation Peptidyl-tyrosine Dephosphorylation Hydrolase Activity MAP Kinase Tyrosine/serine/threonine Phosphatase Activity Protein Tyrosine/serine/threonine Phosphatase Activity Phosphate-containing Compound Metabolic Process Non-membrane Spanning Protein Tyrosine Phosphatase Activity Cation Binding Calmodulin-dependent Protein Phosphatase Activity Regulation Of Phosphatidylinositol Dephosphorylation Intracellular Signaling Cassette Phosphatidylinositol Dephosphorylation Regulation Of ERK1 And ERK2 Cascade Regulation Of MAPK Cascade Peptidyl-threonine Dephosphorylation MAPK Cascade Negative Regulation Of MAPK Cascade Positive Regulation Of Macromolecule Biosynthetic Process Phosphatidylinositol-3,5-bisphosphate 3-phosphatase Activity Negative Regulation Of ERK1 And ERK2 Cascade Phospholipid Dephosphorylation Positive Regulation Of Biosynthetic Process Phosphatidylinositol-3-phosphate Phosphatase Activity Positive Regulation Of Metabolic Process Sequence-specific Double-stranded DNA Binding Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Linear Polyubiquitin Binding Regulation Of Metabolic Process N-terminal Protein Myristoylation Protein Serine/threonine Kinase Binding Regulation Of DNA-templated Transcription Regulation Of Dephosphorylation Regulation Of RNA Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Neuron Differentiation Negative Regulation Of Signaling Receptor Tyrosine Kinase Binding Protein Binding Regulation Of Protein Serine/threonine Kinase Activity Phosphatidylinositol Phosphate Phosphatase Activity Positive Regulation Of Nucleobase-containing Compound Metabolic Process	Mesenchyme Development Protein Kinase Activity Coreceptor Activity Wound Healing Protein Tyrosine Kinase Activity Positive Regulation Of Cardiac Muscle Tissue Development ERBB3:ERBB2 Complex Receptor Complex Response To Wounding ATP Binding Neuregulin Receptor Activity Heart Development ErbB-3 Class Receptor Binding Neuregulin Binding Regulation Of Cardiac Muscle Tissue Development Wnt Signaling Pathway Schwann Cell Differentiation ERBB2-ERBB3 Signaling Pathway Cell Surface Receptor Signaling Pathway ERBB3 Signaling Pathway Axon Lung-associated Mesenchyme Development Negative Regulation Of Motor Neuron Apoptotic Process Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Axon Guidance Receptor Activity Endocardial Cushion Development Convergent Extension Positive Regulation Of Striated Muscle Tissue Development Regulation Of Motor Neuron Apoptotic Process Enzyme-linked Receptor Protein Signaling Pathway Kinase Activity Schwann Cell Development Motor Neuron Apoptotic Process ERBB2 Signaling Pathway Protein Tyrosine Kinase Activator Activity Positive Regulation Of Calcineurin-NFAT Signaling Cascade Mitogen-activated Protein Kinase Kinase Kinase Binding Establishment Of Planar Polarity Establishment Of Apical/basal Cell Polarity Axis Elongation Establishment Of Monopolar Cell Polarity Establishment Of Epithelial Cell Apical/basal Polarity Establishment Or Maintenance Of Monopolar Cell Polarity Polarized Epithelial Cell Differentiation Peripheral Nervous System Development Coronary Vasculature Development Cochlea Morphogenesis Wnt-protein Binding Tissue Development Establishment Of Epithelial Cell Polarity
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