ROR2 and KRTAP6-2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ROR2	KRTAP6-2
Description		receptor tyrosine kinase like orphan receptor 2	keratin associated protein 6-2
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Axon Clathrin-coated Endocytic Vesicle Membrane Receptor Complex	Cytosol Intermediate Filament
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Binding ATP Binding Coreceptor Activity Kinase Activity Transferase Activity Wnt-protein Binding Mitogen-activated Protein Kinase Kinase Kinase Binding Metal Ion Binding	Protein Binding Identical Protein Binding
	Biological Process	Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Wnt Signaling Pathway Positive Regulation Of Cell Migration	Keratinization
Pathways		PCP/CE pathway WNT5A-dependent internalization of FZD2, FZD5 and ROR2	Keratinization
Drugs
Diseases		Robinow syndrome Brachydactyly, including: type A; type B; type D; type E
GWAS		Bipolar disorder (inflammation and infection response interaction) ( 25781172) Bipolar disorder and schizophrenia ( 22688191) Birth weight ( 31043758) Bone mineral density (hip) ( 26911590) Facial morphology ( 31763980) Iris color (L* coordinate) ( 30895295) Nose size ( 27182965) Offspring birth weight ( 31043758) Serum immune biomarker levels ( 32066700) Type 2 diabetes ( 25483131)
Interacting Genes		73 interacting genes: ACTMAP ALG13 ARID5A ATXN7L1 BHLHE40 C10orf55 C1orf94 CDC14A CDC25C CREM CRX DAB1 DAZAP2 DUSP1 DUSP10 DUSP14 DUSP18 DUSP19 DUSP21 DUSP29 DUSP6 ERBB2 EYA2 FAM168B FOSB FZD2 FZD5 HIVEP1 IKBKG ILKAP ISX KRTAP19-7 KRTAP6-2 KRTAP7-1 LHX6 MAGED1 MAP3K7 MTMR1 MTMR2 MTMR6 MTMR9 PITX1 PLA2G10 POU2AF1 PPM1A PPM1B PPM1F PPP3CB PRKAB2 PRR20A PRR20B PRR20C PRR20D PRR20E PRR23E PTPN11 PTPN12 PTPN20 PTPN6 PTPN7 PTPRR RBPMS SOX14 STOX1 STYX TAB1 TENT5A TLX3 TPTE VENTX WNT5A ZMYM4 ZNF34	186 interacting genes: ADAM12 ADAMTSL4 ANAPC11 ANKS1A ANXA11 APOBEC1 AQP1 ARID5A ATG9A ATN1 ATOSB ATPAF2 BEX2 BHLHE40 C10orf55 C1orf94 C6orf15 CAMK2A CAMK2B CASC3 CATSPER1 CCDC120 CCDC17 CCDC28A-AS1 CCER1 CCNK CELF5 CERCAM CERK CFP CHIC2 CIMIP1 CIMIP2B COL8A1 CREB5 CTRC CYSRT1 DAZAP2 DHRS1 DMRT3 ENKD1 ESR2 FAAP20 FAM168A FAM83A FOXD2 FOXD4L1 FOXD4L3 FOXP3 FRS3 GALT GATA3 GCM2 GLIS2 GLYCTK GNE GPS2 GRINA GRN GSTP1 HAPLN2 HELT HEY1 HEY2 HEYL HHEX HOXA1 HOXB9 HOXC8 HOXC9 HSF4 HYAL2 IGFN1 INCA1 INO80B ITGB4 KLHL38 KPRP KRT83 KRTAP11-1 KRTAP12-1 KRTAP12-2 KRTAP12-3 KRTAP12-4 KRTAP15-1 KRTAP19-5 KRTAP26-1 KRTAP3-3 KRTAP4-11 KRTAP4-12 KRTAP6-1 KRTAP6-3 LASP1 LCE2B LCE2D LCE5A LETM1 LGALS9C LRFN4 LRRC41 LYVE1 MEIS2 MGAT5B MKRN3 NAF1 NDUFA9 NEU4 NFKBID NID2 NPBWR2 NR1D2 NSD1 OLIG3 OTX1 OXER1 PATL1 PATZ1 PAX3 PDP1 PHLDA1 PITX1 PKD2 PLEKHN1 PLSCR4 POGZ POU5F2 PRR13 PRR3 PRR30 PRR35 RASD1 RBFOX2 RBPMS2 RERE RHOXF2 RNF38 ROR2 RTP5 RUNX1T1 RUSC1 SAMD7 SAXO4 SHARPIN SIAH3 SMAP2 SMARCC1 SMN1 SMN2 SMUG1 SNRPB SNRPC SPAG8 SPATA8 SPMIP9 TBX6 TCF7L2 TEKT3 TEKT4 TEKT5 TENT5B TENT5D TEPSIN TFAP2D TLE5 TLX2 TLX3 TNIP1 TOLLIP TPRX1 TRIP13 TSGA10IP TSPAN4 TSPYL6 VAC14 VENTX VGLL3 VPS37C YPEL3 ZBTB32 ZC3H10 ZIC1 ZNF414 ZNF503 ZNF581 ZNF683 ZNF843
Entrez ID		4920	337967
HPRD ID		03822	11219
Ensembl ID		ENSG00000169071	ENSG00000186930
Uniprot IDs		Q01974	Q3LI66
PDB IDs		3ZZW 4GT4 6OSH 6OSN 6OSV 9FSE
Enriched GO Terms of Interacting Partners?		Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Dephosphorylation Protein Serine/threonine Phosphatase Activity Protein Dephosphorylation Peptidyl-tyrosine Dephosphorylation Hydrolase Activity MAP Kinase Tyrosine/serine/threonine Phosphatase Activity Protein Tyrosine/serine/threonine Phosphatase Activity Phosphate-containing Compound Metabolic Process Non-membrane Spanning Protein Tyrosine Phosphatase Activity Cation Binding Calmodulin-dependent Protein Phosphatase Activity Regulation Of Phosphatidylinositol Dephosphorylation Intracellular Signaling Cassette Phosphatidylinositol Dephosphorylation Regulation Of ERK1 And ERK2 Cascade Regulation Of MAPK Cascade Peptidyl-threonine Dephosphorylation MAPK Cascade Negative Regulation Of MAPK Cascade Positive Regulation Of Macromolecule Biosynthetic Process Phosphatidylinositol-3,5-bisphosphate 3-phosphatase Activity Negative Regulation Of ERK1 And ERK2 Cascade Phospholipid Dephosphorylation Positive Regulation Of Biosynthetic Process Phosphatidylinositol-3-phosphate Phosphatase Activity Positive Regulation Of Metabolic Process Sequence-specific Double-stranded DNA Binding Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Linear Polyubiquitin Binding Regulation Of Metabolic Process N-terminal Protein Myristoylation Protein Serine/threonine Kinase Binding Regulation Of DNA-templated Transcription Regulation Of Dephosphorylation Regulation Of RNA Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Neuron Differentiation Negative Regulation Of Signaling Receptor Tyrosine Kinase Binding Protein Binding Regulation Of Protein Serine/threonine Kinase Activity Phosphatidylinositol Phosphate Phosphatase Activity Positive Regulation Of Nucleobase-containing Compound Metabolic Process	Protein Binding Chromatin DNA-binding Transcription Factor Activity Sequence-specific Double-stranded DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of RNA Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Intermediate Filament Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Sequence-specific DNA Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Axonemal A Tubule Inner Sheath Negative Regulation Of RNA Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Nucleus Positive Regulation Of RNA Metabolic Process DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Keratin Filament Keratinization Regulation Of Gene Expression Anterior/posterior Pattern Specification Regulation Of Primary Metabolic Process Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Sperm Flagellum DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Transcription Corepressor Activity Positive Regulation Of Biosynthetic Process Umbilical Cord Morphogenesis Pattern Specification Process Identical Protein Binding Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Cardiac Ventricle Morphogenesis Flagellated Sperm Motility Sperm Motility Myoblast Fate Commitment Positive Regulation Of Macromolecule Metabolic Process Hair Cycle Cilium-dependent Cell Motility
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