ROR2 and ALG13

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ROR2	ALG13
Description		receptor tyrosine kinase like orphan receptor 2	ALG13 UDP-N-acetylglucosaminyltransferase subunit
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Axon Clathrin-coated Endocytic Vesicle Membrane Receptor Complex	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane UDP-N-acetylglucosamine Transferase Complex Cytoplasmic Side Of Endoplasmic Reticulum Membrane
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Binding ATP Binding Coreceptor Activity Kinase Activity Transferase Activity Wnt-protein Binding Mitogen-activated Protein Kinase Kinase Kinase Binding Metal Ion Binding	Catalytic Activity N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase Activity Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Transferase Activity Glycosyltransferase Activity Hexosyltransferase Activity Hydrolase Activity
	Biological Process	Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Wnt Signaling Pathway Positive Regulation Of Cell Migration	Protein N-linked Glycosylation Dolichol-linked Oligosaccharide Biosynthetic Process Proteolysis
Pathways		PCP/CE pathway WNT5A-dependent internalization of FZD2, FZD5 and ROR2	Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein Defective ALG14 causes ALG14-CMS
Drugs
Diseases		Robinow syndrome Brachydactyly, including: type A; type B; type D; type E
GWAS		Bipolar disorder (inflammation and infection response interaction) ( 25781172) Bipolar disorder and schizophrenia ( 22688191) Birth weight ( 31043758) Bone mineral density (hip) ( 26911590) Facial morphology ( 31763980) Iris color (L* coordinate) ( 30895295) Nose size ( 27182965) Offspring birth weight ( 31043758) Serum immune biomarker levels ( 32066700) Type 2 diabetes ( 25483131)	Rosacea symptom severity ( 29771307) Shoulder impingement or rotator cuff tear ( 33482370)
Interacting Genes		73 interacting genes: ACTMAP ALG13 ARID5A ATXN7L1 BHLHE40 C10orf55 C1orf94 CDC14A CDC25C CREM CRX DAB1 DAZAP2 DUSP1 DUSP10 DUSP14 DUSP18 DUSP19 DUSP21 DUSP29 DUSP6 ERBB2 EYA2 FAM168B FOSB FZD2 FZD5 HIVEP1 IKBKG ILKAP ISX KRTAP19-7 KRTAP6-2 KRTAP7-1 LHX6 MAGED1 MAP3K7 MTMR1 MTMR2 MTMR6 MTMR9 PITX1 PLA2G10 POU2AF1 PPM1A PPM1B PPM1F PPP3CB PRKAB2 PRR20A PRR20B PRR20C PRR20D PRR20E PRR23E PTPN11 PTPN12 PTPN20 PTPN6 PTPN7 PTPRR RBPMS SOX14 STOX1 STYX TAB1 TENT5A TLX3 TPTE VENTX WNT5A ZMYM4 ZNF34	30 interacting genes: ATN1 ATXN1L BAG4 CPSF7 DMRTB1 EIF4ENIF1 ESRP1 EXOSC7 GRN HOXA1 KRT31 MAPKBP1 NXF2 PCM1 PITX1 PRRC2B QKI RBFOX1 RBFOX2 RBPMS RERE RHOU ROR2 RPL14 SF1 TRIM14 TXNL4A U2AF1 YTHDF3 ZC3H10
Entrez ID		4920	79868
HPRD ID		03822	06542
Ensembl ID		ENSG00000169071	ENSG00000101901
Uniprot IDs		Q01974	A0A087WT15 A0A087WX43 Q9NP73
PDB IDs		3ZZW 4GT4 6OSH 6OSN 6OSV 9FSE
Enriched GO Terms of Interacting Partners?		Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Dephosphorylation Protein Serine/threonine Phosphatase Activity Protein Dephosphorylation Peptidyl-tyrosine Dephosphorylation Hydrolase Activity MAP Kinase Tyrosine/serine/threonine Phosphatase Activity Protein Tyrosine/serine/threonine Phosphatase Activity Phosphate-containing Compound Metabolic Process Non-membrane Spanning Protein Tyrosine Phosphatase Activity Cation Binding Calmodulin-dependent Protein Phosphatase Activity Regulation Of Phosphatidylinositol Dephosphorylation Intracellular Signaling Cassette Phosphatidylinositol Dephosphorylation Regulation Of ERK1 And ERK2 Cascade Regulation Of MAPK Cascade Peptidyl-threonine Dephosphorylation MAPK Cascade Negative Regulation Of MAPK Cascade Positive Regulation Of Macromolecule Biosynthetic Process Phosphatidylinositol-3,5-bisphosphate 3-phosphatase Activity Negative Regulation Of ERK1 And ERK2 Cascade Phospholipid Dephosphorylation Positive Regulation Of Biosynthetic Process Phosphatidylinositol-3-phosphate Phosphatase Activity Positive Regulation Of Metabolic Process Sequence-specific Double-stranded DNA Binding Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Linear Polyubiquitin Binding Regulation Of Metabolic Process N-terminal Protein Myristoylation Protein Serine/threonine Kinase Binding Regulation Of DNA-templated Transcription Regulation Of Dephosphorylation Regulation Of RNA Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Neuron Differentiation Negative Regulation Of Signaling Receptor Tyrosine Kinase Binding Protein Binding Regulation Of Protein Serine/threonine Kinase Activity Phosphatidylinositol Phosphate Phosphatase Activity Positive Regulation Of Nucleobase-containing Compound Metabolic Process	RNA Binding MRNA Binding RNA Processing Nucleic Acid Binding MRNA Processing MRNA Metabolic Process Regulation Of RNA Splicing Regulation Of MRNA Metabolic Process RNA Splicing RNA Metabolic Process Cytoplasmic Stress Granule U2AF Complex Regulation Of MRNA Splicing, Via Spliceosome Nucleus Negative Regulation Of Metabolic Process Regulation Of MRNA Processing Regulation Of Macromolecule Metabolic Process Transcription Coactivator Activity Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Alternative MRNA Splicing, Via Spliceosome Regulation Of Primary Metabolic Process Regulation Of Metabolic Process Regulation Of Defense Response To Bacterium MRNA Splicing, Via Spliceosome Nucleic Acid Metabolic Process Transcription Corepressor Activity Negative Regulation Of RNA Metabolic Process RNA Splicing, Via Transesterification Reactions Regulation Of Nucleobase-containing Compound Metabolic Process P-body Protein Binding Negative Regulation Of MRNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of MRNA Catabolic Process Stress Granule Assembly Positive Regulation Of Aspartic-type Peptidase Activity Semicircular Canal Formation Internal N(7)-methylguanine-containing RNA Reader Activity Negative Regulation Of MRNA Modification Regulation Of Inner Ear Auditory Receptor Cell Fate Specification Negative Regulation Of Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA MiRNA Binding Positive Regulation Of MRNA Metabolic Process RNA Transport Nucleobase-containing Compound Metabolic Process
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