ROR2 and PTPN7

Number of citations of the paper that reports this interaction (PubMedID 28065597)
51

Data Source:
BioGRID (two hybrid)

		ROR2	PTPN7
Description		receptor tyrosine kinase like orphan receptor 2	protein tyrosine phosphatase non-receptor type 7
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GO Annotations	Cellular Component	Plasma Membrane Membrane Axon Clathrin-coated Endocytic Vesicle Membrane Receptor Complex	Nucleoplasm Cytoplasm Cytosol Cytoskeleton Cytoplasmic Side Of Plasma Membrane Microtubule Cytoskeleton Mitotic Spindle
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Binding ATP Binding Coreceptor Activity Kinase Activity Transferase Activity Wnt-protein Binding Mitogen-activated Protein Kinase Kinase Kinase Binding Metal Ion Binding	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Non-membrane Spanning Protein Tyrosine Phosphatase Activity Protein Binding Hydrolase Activity
	Biological Process	Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Wnt Signaling Pathway Positive Regulation Of Cell Migration	MAPK Cascade Protein Dephosphorylation Signal Transduction
Pathways		PCP/CE pathway WNT5A-dependent internalization of FZD2, FZD5 and ROR2	Negative regulation of MAPK pathway Interleukin-37 signaling
Drugs
Diseases		Robinow syndrome Brachydactyly, including: type A; type B; type D; type E
GWAS		Bipolar disorder (inflammation and infection response interaction) ( 25781172) Bipolar disorder and schizophrenia ( 22688191) Birth weight ( 31043758) Bone mineral density (hip) ( 26911590) Facial morphology ( 31763980) Iris color (L* coordinate) ( 30895295) Nose size ( 27182965) Offspring birth weight ( 31043758) Serum immune biomarker levels ( 32066700) Type 2 diabetes ( 25483131)	Basophil percentage of white cells ( 32888494) Breast cancer ( 23535733) Mean spheric corpuscular volume ( 32888494) Plateletcrit ( 32888494)
Interacting Genes		73 interacting genes: ACTMAP ALG13 ARID5A ATXN7L1 BHLHE40 C10orf55 C1orf94 CDC14A CDC25C CREM CRX DAB1 DAZAP2 DUSP1 DUSP10 DUSP14 DUSP18 DUSP19 DUSP21 DUSP29 DUSP6 ERBB2 EYA2 FAM168B FOSB FZD2 FZD5 HIVEP1 IKBKG ILKAP ISX KRTAP19-7 KRTAP6-2 KRTAP7-1 LHX6 MAGED1 MAP3K7 MTMR1 MTMR2 MTMR6 MTMR9 PITX1 PLA2G10 POU2AF1 PPM1A PPM1B PPM1F PPP3CB PRKAB2 PRR20A PRR20B PRR20C PRR20D PRR20E PRR23E PTPN11 PTPN12 PTPN20 PTPN6 PTPN7 PTPRR RBPMS SOX14 STOX1 STYX TAB1 TENT5A TLX3 TPTE VENTX WNT5A ZMYM4 ZNF34	17 interacting genes: AATK APP CCDC57 EGFR EPHA2 ERBB3 ERBB4 GMCL1 IGF1R MAPK1 MAPK14 MAPK3 PPP1CA PRKACA PTK7 ROR2 SIRPA
Entrez ID		4920	5778
HPRD ID		03822	01480
Ensembl ID		ENSG00000169071	ENSG00000143851
Uniprot IDs		Q01974	B4DZD9 P35236
PDB IDs		3ZZW 4GT4 6OSH 6OSN 6OSV 9FSE	1ZC0 2A3K 2GP0 2GPH 2HVL 2QDC 2QDM 2QDP 3D42 3D44 3O4S 3O4T 3O4U
Enriched GO Terms of Interacting Partners?		Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Dephosphorylation Protein Serine/threonine Phosphatase Activity Protein Dephosphorylation Peptidyl-tyrosine Dephosphorylation Hydrolase Activity MAP Kinase Tyrosine/serine/threonine Phosphatase Activity Protein Tyrosine/serine/threonine Phosphatase Activity Phosphate-containing Compound Metabolic Process Non-membrane Spanning Protein Tyrosine Phosphatase Activity Cation Binding Calmodulin-dependent Protein Phosphatase Activity Regulation Of Phosphatidylinositol Dephosphorylation Intracellular Signaling Cassette Phosphatidylinositol Dephosphorylation Regulation Of ERK1 And ERK2 Cascade Regulation Of MAPK Cascade Peptidyl-threonine Dephosphorylation MAPK Cascade Negative Regulation Of MAPK Cascade Positive Regulation Of Macromolecule Biosynthetic Process Phosphatidylinositol-3,5-bisphosphate 3-phosphatase Activity Negative Regulation Of ERK1 And ERK2 Cascade Phospholipid Dephosphorylation Positive Regulation Of Biosynthetic Process Phosphatidylinositol-3-phosphate Phosphatase Activity Positive Regulation Of Metabolic Process Sequence-specific Double-stranded DNA Binding Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Linear Polyubiquitin Binding Regulation Of Metabolic Process N-terminal Protein Myristoylation Protein Serine/threonine Kinase Binding Regulation Of DNA-templated Transcription Regulation Of Dephosphorylation Regulation Of RNA Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Neuron Differentiation Negative Regulation Of Signaling Receptor Tyrosine Kinase Binding Protein Binding Regulation Of Protein Serine/threonine Kinase Activity Phosphatidylinositol Phosphate Phosphatase Activity Positive Regulation Of Nucleobase-containing Compound Metabolic Process	Protein Kinase Activity Kinase Activity ERBB2 Signaling Pathway Protein Tyrosine Kinase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway ATP Binding Receptor Complex Transmembrane Receptor Protein Tyrosine Kinase Activity Regulation Of MAPK Cascade Enzyme-linked Receptor Protein Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Response To Growth Factor Positive Regulation Of Cellular Component Organization Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Transferase Activity Nucleotide Binding ERBB2-ERBB3 Signaling Pathway ERBB3 Signaling Pathway Regulation Of Cell Migration Regulation Of Cell Motility Animal Organ Development Regulation Of Signal Transduction Response To Epidermal Growth Factor Regulation Of Locomotion Regulation Of ERK1 And ERK2 Cascade Regulation Of Intracellular Signal Transduction Glial Cell Development MAP Kinase Activity Intracellular Signaling Cassette Schwann Cell Development Apoptotic Process Regulation Of Cell Communication Regulation Of Signaling Programmed Cell Death Cell Death Positive Regulation Of Cell Communication Positive Regulation Of Signaling Stress-activated MAPK Cascade Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of Protein Localization Epidermal Growth Factor Receptor Activity Neuregulin Receptor Activity Interleukin-34-mediated Signaling Pathway Regulation Of Cellular Component Organization Anatomical Structure Morphogenesis
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