ROR2 and PITX1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ROR2	PITX1
Description		receptor tyrosine kinase like orphan receptor 2	paired like homeodomain 1
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Axon Clathrin-coated Endocytic Vesicle Membrane Receptor Complex	Chromatin Nucleus Transcription Regulator Complex Cytoplasm
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Binding ATP Binding Coreceptor Activity Kinase Activity Transferase Activity Wnt-protein Binding Mitogen-activated Protein Kinase Kinase Kinase Binding Metal Ion Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Wnt Signaling Pathway Positive Regulation Of Cell Migration	Skeletal System Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Anatomical Structure Morphogenesis Branchiomeric Skeletal Muscle Development Pituitary Gland Development Embryonic Hindlimb Morphogenesis Hindlimb Morphogenesis Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Myoblast Fate Commitment Cartilage Development
Pathways		PCP/CE pathway WNT5A-dependent internalization of FZD2, FZD5 and ROR2
Drugs
Diseases		Robinow syndrome Brachydactyly, including: type A; type B; type D; type E	Congenital clubfoot; Congenital talipes equinovarus
GWAS		Bipolar disorder (inflammation and infection response interaction) ( 25781172) Bipolar disorder and schizophrenia ( 22688191) Birth weight ( 31043758) Bone mineral density (hip) ( 26911590) Facial morphology ( 31763980) Iris color (L* coordinate) ( 30895295) Nose size ( 27182965) Offspring birth weight ( 31043758) Serum immune biomarker levels ( 32066700) Type 2 diabetes ( 25483131)	Appendicular lean mass ( 33097823) Atrial fibrillation ( 29237688) Bulimia nervosa ( 23568457) Colorectal cancer ( 23263487 30529582 24836286) Colorectal cancer or advanced adenoma ( 30510241) DHEAS levels ( 34748635) Height ( 25429064 31562340 18391951 23563607 20881960) Hip circumference adjusted for BMI ( 34021172) Immune response to anthrax vaccine ( 22658931) Testicular germ cell tumor ( 28604732 23666240)
Interacting Genes		73 interacting genes: ACTMAP ALG13 ARID5A ATXN7L1 BHLHE40 C10orf55 C1orf94 CDC14A CDC25C CREM CRX DAB1 DAZAP2 DUSP1 DUSP10 DUSP14 DUSP18 DUSP19 DUSP21 DUSP29 DUSP6 ERBB2 EYA2 FAM168B FOSB FZD2 FZD5 HIVEP1 IKBKG ILKAP ISX KRTAP19-7 KRTAP6-2 KRTAP7-1 LHX6 MAGED1 MAP3K7 MTMR1 MTMR2 MTMR6 MTMR9 PITX1 PLA2G10 POU2AF1 PPM1A PPM1B PPM1F PPP3CB PRKAB2 PRR20A PRR20B PRR20C PRR20D PRR20E PRR23E PTPN11 PTPN12 PTPN20 PTPN6 PTPN7 PTPRR RBPMS SOX14 STOX1 STYX TAB1 TENT5A TLX3 TPTE VENTX WNT5A ZMYM4 ZNF34	98 interacting genes: - ABHD11 ACTMAP AKAP8L ALG13 ANKRD10 ARID5A ATN1 BPIFA1 C10orf55 C1orf94 C9orf57 CDX4 CEACAM6 CFAP68 CYSRT1 DCTN3 DVL3 DZIP3 EFEMP2 EGR1 FAM168A FAM168B FOXO1 GATA1 GOLGA2 HGS HOXA1 HSF4 HYI IGFL2 IPO13 KLHL26 KRT34 KRT83 KRTAP13-1 KRTAP13-2 KRTAP19-5 KRTAP19-7 KRTAP26-1 KRTAP3-3 KRTAP6-1 KRTAP6-2 KRTAP6-3 KRTAP7-1 KRTAP8-1 LASP1 LZTS2 MAGED1 METTL27 MGAT5B MSX2 MYH7B MYOZ3 NEUROD1 NHLRC4 NID2 NR5A1 PFDN5 PLA2G10 PLEKHB2 PLSCR1 PLSCR3 POU1F1 PRR20A PRR20B PRR20C PRR20D PRR20E PSMB11 PTK6 RBPMS RFX6 RHOXF2 RNF31 ROR2 SERGEF SERPINE1 SLC15A2 SMARCA2 SPAG8 STH TBX19 TBX22 TEKT5 TFAP2D TLE5 TP53BP1 TRAF1 TRAPPC2 TRIM23 TSC1 UFSP1 UPF2 VGLL3 YPEL3 ZBTB32 ZNF34
Entrez ID		4920	5307
HPRD ID		03822	03688
Ensembl ID		ENSG00000169071	ENSG00000069011
Uniprot IDs		Q01974	P78337 X5D9A5
PDB IDs		3ZZW 4GT4 6OSH 6OSN 6OSV 9FSE
Enriched GO Terms of Interacting Partners?		Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Dephosphorylation Protein Serine/threonine Phosphatase Activity Protein Dephosphorylation Peptidyl-tyrosine Dephosphorylation Hydrolase Activity MAP Kinase Tyrosine/serine/threonine Phosphatase Activity Protein Tyrosine/serine/threonine Phosphatase Activity Phosphate-containing Compound Metabolic Process Non-membrane Spanning Protein Tyrosine Phosphatase Activity Cation Binding Calmodulin-dependent Protein Phosphatase Activity Regulation Of Phosphatidylinositol Dephosphorylation Intracellular Signaling Cassette Phosphatidylinositol Dephosphorylation Regulation Of ERK1 And ERK2 Cascade Regulation Of MAPK Cascade Peptidyl-threonine Dephosphorylation MAPK Cascade Negative Regulation Of MAPK Cascade Positive Regulation Of Macromolecule Biosynthetic Process Phosphatidylinositol-3,5-bisphosphate 3-phosphatase Activity Negative Regulation Of ERK1 And ERK2 Cascade Phospholipid Dephosphorylation Positive Regulation Of Biosynthetic Process Phosphatidylinositol-3-phosphate Phosphatase Activity Positive Regulation Of Metabolic Process Sequence-specific Double-stranded DNA Binding Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Linear Polyubiquitin Binding Regulation Of Metabolic Process N-terminal Protein Myristoylation Protein Serine/threonine Kinase Binding Regulation Of DNA-templated Transcription Regulation Of Dephosphorylation Regulation Of RNA Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Neuron Differentiation Negative Regulation Of Signaling Receptor Tyrosine Kinase Binding Protein Binding Regulation Of Protein Serine/threonine Kinase Activity Phosphatidylinositol Phosphate Phosphatase Activity Positive Regulation Of Nucleobase-containing Compound Metabolic Process	Intermediate Filament Chromatin Protein Binding Keratin Filament DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Sequence-specific Double-stranded DNA Binding Lead Ion Binding Sequence-specific DNA Binding Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Activity Positive Regulation Of Nucleobase-containing Compound Metabolic Process Mercury Ion Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Regulation Of Smooth Muscle Cell-matrix Adhesion Positive Regulation Of Transcription By RNA Polymerase II Axonemal A Tubule Inner Sheath Negative Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Structural Molecule Activity
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