XRN2 and SETMAR

		XRN2	SETMAR
Description		5'-3' exoribonuclease 2	SET and mariner transposase domain methyltransferase
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Membrane Aggresome	Condensed Chromosome Nucleus Chromosome Nucleolus Site Of Double-strand Break
	Molecular Function	3'-5'-RNA Exonuclease Activity Transcription Termination Site Sequence-specific DNA Binding Nucleic Acid Binding DNA Binding RNA Binding Nuclease Activity Exonuclease Activity 5'-3' RNA Exonuclease Activity Protein Binding Zinc Ion Binding 5'-3' Exonuclease Activity Hydrolase Activity Identical Protein Binding Metal Ion Binding	Single-stranded DNA Endodeoxyribonuclease Activity Nucleic Acid Binding DNA Binding Double-stranded DNA Binding Single-stranded DNA Binding Catalytic Activity Nuclease Activity Endonuclease Activity Protein Binding Methyltransferase Activity Zinc Ion Binding Protein-lysine N-methyltransferase Activity Transferase Activity Hydrolase Activity Histone Methyltransferase Activity Histone H3K4 Methyltransferase Activity Protein Homodimerization Activity DNA Topoisomerase Binding Metal Ion Binding Histone H3K36 Methyltransferase Activity Histone H3 Methyltransferase Activity Histone H3K36 Dimethyltransferase Activity
	Biological Process	Nuclear-transcribed MRNA Catabolic Process Nucleobase-containing Compound Metabolic Process DNA-templated Transcription Termination RRNA Processing Termination Of RNA Polymerase II Transcription RNA Processing MRNA Processing RNA Catabolic Process Spermatogenesis RNA Metabolic Process Hippocampus Development Neuron Differentiation Retina Development In Camera-type Eye	DNA Double-strand Break Processing DNA Repair Double-strand Break Repair Via Nonhomologous End Joining DNA Catabolic Process Chromatin Organization Chromatin Remodeling DNA Damage Response Cell Population Proliferation DNA Integration Replication Fork Processing Methylation Mitotic DNA Integrity Checkpoint Signaling Nucleic Acid Metabolic Process Positive Regulation Of DNA Topoisomerase (ATP-hydrolyzing) Activity Positive Regulation Of Double-strand Break Repair Via Nonhomologous End Joining Negative Regulation Of Chromosome Organization
Pathways		Association of TriC/CCT with target proteins during biosynthesis Major pathway of rRNA processing in the nucleolus and cytosol Nuclear RNA decay
Drugs
Diseases
GWAS		Autism spectrum disorder ( 30804558) Hip circumference adjusted for BMI ( 34021172) Lupus nephritis in systemic lupus erythematosus ( 24925725) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular volume ( 32888494) Red cell distribution width ( 32888494)	Fractures (paediatric) ( 32742401) Midgestational circulating levels of PCBs ( 28235828) Periodontitis (DPAL) ( 24024966) Refractive error ( 32231278) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Spondylosis ( 33332786)
Interacting Genes		46 interacting genes: ALDH1B1 APP ATRN BFSP1 CEBPA COMT CRY2 CSNK2A1 CTSC DSCAM DSCR9 DXO DYNLT1 EEF1A1 EIF3L EIF5A EIF6 ERG EXOSC10 EXOSC8 LCN2 LSM3 MAGEA11 MOCS3 MRPL4 MRPS10 OGT PGM1 PLEKHF2 PRAME PSMA3 PYGB RAB14 RNF10 RNF8 SETMAR STK39 TARDBP TIPARP TOLLIP TTC23 TTC3 UPF2 USP16 USP7 YTHDF1	4 interacting genes: H3-5 PRPF19 VPS26C XRN2
Entrez ID		22803	6419
HPRD ID		10309	10225
Ensembl ID		ENSG00000088930	ENSG00000170364
Uniprot IDs		B4DZC3 Q9H0D6	B4DND2 Q53H47 Q96H41
PDB IDs			3BO5 3F2K 3K9J 3K9K 7S03
Enriched GO Terms of Interacting Partners?		Macromolecule Metabolic Process Protein Metabolic Process Macromolecule Catabolic Process Nuclear MRNA Surveillance Catabolic Process Positive Regulation Of Protein Metabolic Process Nuclear-transcribed MRNA Catabolic Process Regulation Of Protein Metabolic Process Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process Memory Symbiont-mediated Disruption Of Host Cell PML Body MRNA Catabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Nucleobase-containing Compound Catabolic Process Translation Positive Regulation Of Translational Elongation Regulation Of Protein Catabolic Process Positive Regulation Of Translation Positive Regulation Of Metabolic Process Positive Regulation Of Catabolic Process Response To Blue Light Regulation Of Translation Nuclear RNA Surveillance Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) TRNA Surveillance TRAMP-dependent TRNA Surveillance Pathway Nuclear Polyadenylation-dependent RRNA Catabolic Process RNA Surveillance Kinase Binding RNA Catabolic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Monoubiquitinated Protein Deubiquitination Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process RRNA 3'-end Processing Nucleolar Exosome (RNase Complex) Cytosol Regulation Of Translational Elongation TRNA Decay Regulation Of Glycolytic Process Regulation Of Macromolecule Metabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Metabolic Process Regulation Of Proteolysis Double-strand Break Repair Via Nonhomologous End Joining Nucleic Acid Metabolic Process Nucleoplasm Rhythmic Process
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