XRN2 and MOCS3

Number of citations of the paper that reports this interaction (PubMedID 15231747)
47

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		XRN2	MOCS3
Description		5'-3' exoribonuclease 2	molybdenum cofactor synthesis 3
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Membrane Aggresome	Cytoplasm Cytosol
	Molecular Function	3'-5'-RNA Exonuclease Activity Transcription Termination Site Sequence-specific DNA Binding Nucleic Acid Binding DNA Binding RNA Binding Nuclease Activity Exonuclease Activity 5'-3' RNA Exonuclease Activity Protein Binding Zinc Ion Binding 5'-3' Exonuclease Activity Hydrolase Activity Identical Protein Binding Metal Ion Binding	Nucleotide Binding Catalytic Activity Thiosulfate-cyanide Sulfurtransferase Activity Protein Binding ATP Binding Ubiquitin-like Modifier Activating Enzyme Activity Transferase Activity Nucleotidyltransferase Activity Sulfurtransferase Activity URM1 Activating Enzyme Activity Metal Ion Binding Molybdopterin-synthase Sulfurtransferase Activity Molybdopterin-synthase Adenylyltransferase Activity Adenylyltransferase Activity
	Biological Process	Nuclear-transcribed MRNA Catabolic Process Nucleobase-containing Compound Metabolic Process DNA-templated Transcription Termination RRNA Processing Termination Of RNA Polymerase II Transcription RNA Processing MRNA Processing RNA Catabolic Process Spermatogenesis RNA Metabolic Process Hippocampus Development Neuron Differentiation Retina Development In Camera-type Eye	TRNA Wobble Uridine Modification TRNA Wobble Position Uridine Thiolation Mo-molybdopterin Cofactor Biosynthetic Process TRNA Processing Protein Urmylation TRNA Thio-modification
Pathways		Association of TriC/CCT with target proteins during biosynthesis Major pathway of rRNA processing in the nucleolus and cytosol Nuclear RNA decay	Molybdenum cofactor biosynthesis
Drugs
Diseases
GWAS		Autism spectrum disorder ( 30804558) Hip circumference adjusted for BMI ( 34021172) Lupus nephritis in systemic lupus erythematosus ( 24925725) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular volume ( 32888494) Red cell distribution width ( 32888494)	Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756)
Interacting Genes		46 interacting genes: ALDH1B1 APP ATRN BFSP1 CEBPA COMT CRY2 CSNK2A1 CTSC DSCAM DSCR9 DXO DYNLT1 EEF1A1 EIF3L EIF5A EIF6 ERG EXOSC10 EXOSC8 LCN2 LSM3 MAGEA11 MOCS3 MRPL4 MRPS10 OGT PGM1 PLEKHF2 PRAME PSMA3 PYGB RAB14 RNF10 RNF8 SETMAR STK39 TARDBP TIPARP TOLLIP TTC23 TTC3 UPF2 USP16 USP7 YTHDF1	4 interacting genes: EXOSC6 MOCS2 SLC9A8 XRN2
Entrez ID		22803	27304
HPRD ID		10309	10092
Ensembl ID		ENSG00000088930	ENSG00000124217
Uniprot IDs		B4DZC3 Q9H0D6	O95396
PDB IDs			3I2V
Enriched GO Terms of Interacting Partners?		Macromolecule Metabolic Process Protein Metabolic Process Macromolecule Catabolic Process Nuclear MRNA Surveillance Catabolic Process Positive Regulation Of Protein Metabolic Process Nuclear-transcribed MRNA Catabolic Process Regulation Of Protein Metabolic Process Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process Memory Symbiont-mediated Disruption Of Host Cell PML Body MRNA Catabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Nucleobase-containing Compound Catabolic Process Translation Positive Regulation Of Translational Elongation Regulation Of Protein Catabolic Process Positive Regulation Of Translation Positive Regulation Of Metabolic Process Positive Regulation Of Catabolic Process Response To Blue Light Regulation Of Translation Nuclear RNA Surveillance Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) TRNA Surveillance TRAMP-dependent TRNA Surveillance Pathway Nuclear Polyadenylation-dependent RRNA Catabolic Process RNA Surveillance Kinase Binding RNA Catabolic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Monoubiquitinated Protein Deubiquitination Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process RRNA 3'-end Processing Nucleolar Exosome (RNase Complex) Cytosol Regulation Of Translational Elongation TRNA Decay Regulation Of Glycolytic Process Regulation Of Macromolecule Metabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Metabolic Process Regulation Of Proteolysis Double-strand Break Repair Via Nonhomologous End Joining Nucleic Acid Metabolic Process Nucleoplasm Rhythmic Process	Molybdopterin Cofactor Metabolic Process Mo-molybdopterin Cofactor Biosynthetic Process Molybdopterin Synthase Activity Molybdopterin Synthase Complex Molybdopterin Cofactor Biosynthetic Process MRNA Catabolic Process Transcription Termination Site Sequence-specific DNA Binding RRNA Processing Nuclear-transcribed MRNA Catabolic Process RNA Catabolic Process 5'-3' RNA Exonuclease Activity RRNA Metabolic Process Regulation Of Golgi Lumen Acidification Termination Of RNA Polymerase II Transcription Poly(A)-dependent SnoRNA 3'-end Processing U4 SnRNA 3'-end Processing Nucleobase-containing Compound Catabolic Process 5'-3' Exonuclease Activity Sodium:proton Antiporter Activity Potassium:proton Antiporter Activity Nuclear MRNA Surveillance DNA Deamination Nucleolar Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) RNA Exonuclease Activity RRNA Catabolic Process Nuclear Exosome (RNase Complex) Exosome (RNase Complex) Sno(s)RNA Metabolic Process Male Gamete Generation Spermatogenesis DNA-templated Transcription Termination SnRNA 3'-end Processing Gamete Generation Isotype Switching Somatic Recombination Of Immunoglobulin Genes Involved In Immune Response Multivesicular Body Membrane Positive Regulation Of Isotype Switching Somatic Diversification Of Immunoglobulins Involved In Immune Response DNA Modification 3'-5'-RNA Exonuclease Activity MRNA Metabolic Process Acrosome Assembly Aggresome SnRNA Processing Somatic Recombination Of Immunoglobulin Gene Segments Nuclear RNA Surveillance Regulation Of Isotype Switching RNA Surveillance Positive Regulation Of Immunoglobulin Mediated Immune Response
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