XRN2 and PYGB

		XRN2	PYGB
Description		5'-3' exoribonuclease 2	glycogen phosphorylase B
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Membrane Aggresome	Extracellular Region Cytoplasm Membrane Azurophil Granule Lumen Extracellular Exosome
	Molecular Function	3'-5'-RNA Exonuclease Activity Transcription Termination Site Sequence-specific DNA Binding Nucleic Acid Binding DNA Binding RNA Binding Nuclease Activity Exonuclease Activity 5'-3' RNA Exonuclease Activity Protein Binding Zinc Ion Binding 5'-3' Exonuclease Activity Hydrolase Activity Identical Protein Binding Metal Ion Binding	Catalytic Activity 1,4-alpha-oligoglucan Phosphorylase Activity Protein Binding Glycogen Phosphorylase Activity Transferase Activity Glycosyltransferase Activity Pyridoxal Phosphate Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process Nucleobase-containing Compound Metabolic Process DNA-templated Transcription Termination RRNA Processing Termination Of RNA Polymerase II Transcription RNA Processing MRNA Processing RNA Catabolic Process Spermatogenesis RNA Metabolic Process Hippocampus Development Neuron Differentiation Retina Development In Camera-type Eye	Carbohydrate Metabolic Process Glycogen Metabolic Process Glycogen Catabolic Process
Pathways		Association of TriC/CCT with target proteins during biosynthesis Major pathway of rRNA processing in the nucleolus and cytosol Nuclear RNA decay	Neutrophil degranulation Glycogen breakdown (glycogenolysis)
Drugs			Pyridoxal phosphate Alvocidib
Diseases
GWAS		Autism spectrum disorder ( 30804558) Hip circumference adjusted for BMI ( 34021172) Lupus nephritis in systemic lupus erythematosus ( 24925725) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular volume ( 32888494) Red cell distribution width ( 32888494)	Brain morphology (MOSTest) ( 32665545) Calcium levels ( 24068962) Diisocyanate-induced asthma ( 25918132) Liver enzyme levels (alkaline phosphatase) ( 22001757 33972514) Platelet distribution width ( 32888494) Serum alkaline phosphatase levels ( 31666285) Telomere length ( 30185882) TPE interval (resting) ( 32386560)
Interacting Genes		46 interacting genes: ALDH1B1 APP ATRN BFSP1 CEBPA COMT CRY2 CSNK2A1 CTSC DSCAM DSCR9 DXO DYNLT1 EEF1A1 EIF3L EIF5A EIF6 ERG EXOSC10 EXOSC8 LCN2 LSM3 MAGEA11 MOCS3 MRPL4 MRPS10 OGT PGM1 PLEKHF2 PRAME PSMA3 PYGB RAB14 RNF10 RNF8 SETMAR STK39 TARDBP TIPARP TOLLIP TTC23 TTC3 UPF2 USP16 USP7 YTHDF1	6 interacting genes: ACTN1 CDH5 PPP1R3B PYGL SIAH1 XRN2
Entrez ID		22803	5834
HPRD ID		10309	00720
Ensembl ID		ENSG00000088930	ENSG00000100994
Uniprot IDs		B4DZC3 Q9H0D6	P11216
PDB IDs			5IKO 5IKP
Enriched GO Terms of Interacting Partners?		Macromolecule Metabolic Process Protein Metabolic Process Macromolecule Catabolic Process Nuclear MRNA Surveillance Catabolic Process Positive Regulation Of Protein Metabolic Process Nuclear-transcribed MRNA Catabolic Process Regulation Of Protein Metabolic Process Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process Memory Symbiont-mediated Disruption Of Host Cell PML Body MRNA Catabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Nucleobase-containing Compound Catabolic Process Translation Positive Regulation Of Translational Elongation Regulation Of Protein Catabolic Process Positive Regulation Of Translation Positive Regulation Of Metabolic Process Positive Regulation Of Catabolic Process Response To Blue Light Regulation Of Translation Nuclear RNA Surveillance Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) TRNA Surveillance TRAMP-dependent TRNA Surveillance Pathway Nuclear Polyadenylation-dependent RRNA Catabolic Process RNA Surveillance Kinase Binding RNA Catabolic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Monoubiquitinated Protein Deubiquitination Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process RRNA 3'-end Processing Nucleolar Exosome (RNase Complex) Cytosol Regulation Of Translational Elongation TRNA Decay Regulation Of Glycolytic Process Regulation Of Macromolecule Metabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Metabolic Process Regulation Of Proteolysis Double-strand Break Repair Via Nonhomologous End Joining Nucleic Acid Metabolic Process Nucleoplasm Rhythmic Process	Glycogen Metabolic Process Energy Reserve Metabolic Process Polysaccharide Metabolic Process Structural Constituent Of Postsynapse Vitamin Binding Purine Nucleobase Binding Transcription Termination Site Sequence-specific DNA Binding Negative Regulation Of Glycogen Catabolic Process [phosphorylase] Phosphatase Activity Transmembrane Transporter Binding Platelet Morphogenesis Glycogen Phosphorylase Activity Cell-cell Junction Cell Junction Cell Morphogenesis Identical Protein Binding Actin Filament Network Formation Positive Regulation Of Establishment Of Endothelial Barrier Protein Localization To Bicellular Tight Junction 1,4-alpha-oligoglucan Phosphorylase Activity Energy Derivation By Oxidation Of Organic Compounds 5'-3' RNA Exonuclease Activity Glycogen Granule Blood Vessel Maturation Fibrinogen Binding Bile Acid Binding Termination Of RNA Polymerase II Transcription Fascia Adherens Regulation Of Glycogen Catabolic Process Vascular Endothelial Growth Factor Receptor 2 Binding Glycogen Binding Cell Junction Assembly D-glucose Binding 5'-3' Exonuclease Activity Vinculin Binding BMP Receptor Binding Macromolecule Catabolic Process AMP Binding Beta-catenin Destruction Complex Endothelial Cell Morphogenesis Negative Regulation Of Microtubule Polymerization Generation Of Precursor Metabolites And Energy Protein Phosphatase Type 1 Complex Necroptotic Process
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