XRN2 and ALDH1B1

Number of citations of the paper that reports this interaction (PubMedID 15231747)
47

Data Source:
BioGRID (two hybrid)

		XRN2	ALDH1B1
Description		5'-3' exoribonuclease 2	aldehyde dehydrogenase 1 family member B1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Membrane Aggresome	Nucleoplasm Mitochondrion Mitochondrial Matrix Cytosol
	Molecular Function	3'-5'-RNA Exonuclease Activity Transcription Termination Site Sequence-specific DNA Binding Nucleic Acid Binding DNA Binding RNA Binding Nuclease Activity Exonuclease Activity 5'-3' RNA Exonuclease Activity Protein Binding Zinc Ion Binding 5'-3' Exonuclease Activity Hydrolase Activity Identical Protein Binding Metal Ion Binding	Aldehyde Dehydrogenase (NAD+) Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On The Aldehyde Or Oxo Group Of Donors, NAD Or NADP As Acceptor NAD Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process Nucleobase-containing Compound Metabolic Process DNA-templated Transcription Termination RRNA Processing Termination Of RNA Polymerase II Transcription RNA Processing MRNA Processing RNA Catabolic Process Spermatogenesis RNA Metabolic Process Hippocampus Development Neuron Differentiation Retina Development In Camera-type Eye	Carbohydrate Metabolic Process Ethanol Catabolic Process Aldehyde Metabolic Process
Pathways		Association of TriC/CCT with target proteins during biosynthesis Major pathway of rRNA processing in the nucleolus and cytosol Nuclear RNA decay	Ethanol oxidation Mitochondrial protein degradation
Drugs			NADH
Diseases
GWAS		Autism spectrum disorder ( 30804558) Hip circumference adjusted for BMI ( 34021172) Lupus nephritis in systemic lupus erythematosus ( 24925725) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular volume ( 32888494) Red cell distribution width ( 32888494)	Alcohol consumption (drinkers vs non-drinkers) ( 31959922) Clostridioides difficle infection in antibiotics-users ( 33841421) Emphysema annual change measurement in smokers (percent low attenuation area) ( 31324189) Longevity (100 years and older) ( 33948810) Metabolite levels ( 23823483) Pulse pressure ( 27841878) Smoking status (ever vs never smokers) ( 30643258) Systolic blood pressure ( 27841878) Type 2 diabetes (age of onset) ( 28060188)
Interacting Genes		46 interacting genes: ALDH1B1 APP ATRN BFSP1 CEBPA COMT CRY2 CSNK2A1 CTSC DSCAM DSCR9 DXO DYNLT1 EEF1A1 EIF3L EIF5A EIF6 ERG EXOSC10 EXOSC8 LCN2 LSM3 MAGEA11 MOCS3 MRPL4 MRPS10 OGT PGM1 PLEKHF2 PRAME PSMA3 PYGB RAB14 RNF10 RNF8 SETMAR STK39 TARDBP TIPARP TOLLIP TTC23 TTC3 UPF2 USP16 USP7 YTHDF1	6 interacting genes: EXOSC10 FABP2 FES FILNC1 OGT XRN2
Entrez ID		22803	219
HPRD ID		10309	00005
Ensembl ID		ENSG00000088930	ENSG00000137124
Uniprot IDs		B4DZC3 Q9H0D6	A0A384MTJ7 P30837
PDB IDs			7MJC 7MJD 7RAD
Enriched GO Terms of Interacting Partners?		Macromolecule Metabolic Process Protein Metabolic Process Macromolecule Catabolic Process Nuclear MRNA Surveillance Catabolic Process Positive Regulation Of Protein Metabolic Process Nuclear-transcribed MRNA Catabolic Process Regulation Of Protein Metabolic Process Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process Memory Symbiont-mediated Disruption Of Host Cell PML Body MRNA Catabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Nucleobase-containing Compound Catabolic Process Translation Positive Regulation Of Translational Elongation Regulation Of Protein Catabolic Process Positive Regulation Of Translation Positive Regulation Of Metabolic Process Positive Regulation Of Catabolic Process Response To Blue Light Regulation Of Translation Nuclear RNA Surveillance Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) TRNA Surveillance TRAMP-dependent TRNA Surveillance Pathway Nuclear Polyadenylation-dependent RRNA Catabolic Process RNA Surveillance Kinase Binding RNA Catabolic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Monoubiquitinated Protein Deubiquitination Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process RRNA 3'-end Processing Nucleolar Exosome (RNase Complex) Cytosol Regulation Of Translational Elongation TRNA Decay Regulation Of Glycolytic Process Regulation Of Macromolecule Metabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Metabolic Process Regulation Of Proteolysis Double-strand Break Repair Via Nonhomologous End Joining Nucleic Acid Metabolic Process Nucleoplasm Rhythmic Process	Cellular Response To Nutrient 3'-5'-RNA Exonuclease Activity Lipid Binding Exonuclease Activity Nuclear Polyadenylation-dependent Antisense Transcript Catabolic Process Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Nuclear Polyadenylation-dependent SnoRNA Catabolic Process Nuclear Polyadenylation-dependent SnRNA Catabolic Process Nuclear Polyadenylation-dependent CUT Catabolic Process Nuclease Activity Nuclear-transcribed MRNA Catabolic Process Transcription Termination Site Sequence-specific DNA Binding MRNA Catabolic Process Apical Cortex Long-chain Fatty Acid Binding Response To Nutrient Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) TRNA Surveillance RNA Catabolic Process SnRNA Catabolic Process TRAMP-dependent TRNA Surveillance Pathway RRNA Processing Nuclear Polyadenylation-dependent RRNA Catabolic Process Sno(s)RNA Catabolic Process Positive Regulation Of MRNA Cis Splicing, Via Spliceosome CUT Catabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Non-canonical Inflammasome Complex Assembly Positive Regulation Of Transcription By Glucose Carbon Catabolite Regulation Of Transcription Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Protein O-acetylglucosaminyltransferase Activity Termination Of RNA Polymerase II Transcription 5'-3' RNA Exonuclease Activity Poly(A)-dependent SnoRNA 3'-end Processing RRNA Metabolic Process Positive Regulation Of Monocyte Differentiation Cellular Response To Nutrient Levels RRNA 3'-end Processing Nucleolar Exosome (RNase Complex) Regulation Of Transcription By Glucose 5'-3' Exonuclease Activity Cellular Response To Vitamin D TRNA Decay Nuclear MRNA Surveillance NSL Complex Myoblast Proliferation Regulation Of Telomerase RNA Localization To Cajal Body Intestinal Lipid Absorption
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