XRN2 and RAB14

		XRN2	RAB14
Description		5'-3' exoribonuclease 2	RAB14, member RAS oncogene family
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Membrane Aggresome	Golgi Membrane Lysosome Lysosomal Membrane Endosome Early Endosome Late Endosome Rough Endoplasmic Reticulum Golgi Apparatus Golgi Stack Trans-Golgi Network Cytosol Plasma Membrane Cilium Endomembrane System Membrane Trans-Golgi Network Transport Vesicle Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Early Endosome Membrane Nuclear Outer Membrane-endoplasmic Reticulum Membrane Network Phagocytic Vesicle Perinuclear Region Of Cytoplasm Recycling Endosome Recycling Endosome Membrane Extracellular Exosome Tertiary Granule Membrane
	Molecular Function	3'-5'-RNA Exonuclease Activity Transcription Termination Site Sequence-specific DNA Binding Nucleic Acid Binding DNA Binding RNA Binding Nuclease Activity Exonuclease Activity 5'-3' RNA Exonuclease Activity Protein Binding Zinc Ion Binding 5'-3' Exonuclease Activity Hydrolase Activity Identical Protein Binding Metal Ion Binding	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding Myosin V Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process Nucleobase-containing Compound Metabolic Process DNA-templated Transcription Termination RRNA Processing Termination Of RNA Polymerase II Transcription RNA Processing MRNA Processing RNA Catabolic Process Spermatogenesis RNA Metabolic Process Hippocampus Development Neuron Differentiation Retina Development In Camera-type Eye	Phagolysosome Assembly Intracellular Protein Transport Golgi To Endosome Transport Fibroblast Growth Factor Receptor Signaling Pathway Protein Transport Vesicle-mediated Transport Endocytic Recycling Regulation Of Protein Localization Endosomal Vesicle Fusion Early Endosome To Golgi Transport Defense Response To Bacterium Regulation Of Embryonic Development Intracellular Transport Phagosome Maturation
Pathways		Association of TriC/CCT with target proteins during biosynthesis Major pathway of rRNA processing in the nucleolus and cytosol Nuclear RNA decay	Translocation of SLC2A4 (GLUT4) to the plasma membrane Synthesis of PIPs at the plasma membrane Neutrophil degranulation RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs
Drugs
Diseases
GWAS		Autism spectrum disorder ( 30804558) Hip circumference adjusted for BMI ( 34021172) Lupus nephritis in systemic lupus erythematosus ( 24925725) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular volume ( 32888494) Red cell distribution width ( 32888494)	Immune reponse to smallpox (secreted IFN-alpha) ( 22610502)
Interacting Genes		46 interacting genes: ALDH1B1 APP ATRN BFSP1 CEBPA COMT CRY2 CSNK2A1 CTSC DSCAM DSCR9 DXO DYNLT1 EEF1A1 EIF3L EIF5A EIF6 ERG EXOSC10 EXOSC8 LCN2 LSM3 MAGEA11 MOCS3 MRPL4 MRPS10 OGT PGM1 PLEKHF2 PRAME PSMA3 PYGB RAB14 RNF10 RNF8 SETMAR STK39 TARDBP TIPARP TOLLIP TTC23 TTC3 UPF2 USP16 USP7 YTHDF1	20 interacting genes: ADRB2 APP ARHGEF17 ARL8B CHM EXOC5 FGA GARIN6 GSN NR5A1 OCRL OPTN RAB11FIP5 RBSN RUFY1 SH3BP5L SMURF2 TLR4 TNC XRN2
Entrez ID		22803	51552
HPRD ID		10309	06693
Ensembl ID		ENSG00000088930	ENSG00000119396
Uniprot IDs		B4DZC3 Q9H0D6	P61106
PDB IDs			1Z0F 4D0G 4DRZ
Enriched GO Terms of Interacting Partners?		Macromolecule Metabolic Process Protein Metabolic Process Macromolecule Catabolic Process Nuclear MRNA Surveillance Catabolic Process Positive Regulation Of Protein Metabolic Process Nuclear-transcribed MRNA Catabolic Process Regulation Of Protein Metabolic Process Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process Memory Symbiont-mediated Disruption Of Host Cell PML Body MRNA Catabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Nucleobase-containing Compound Catabolic Process Translation Positive Regulation Of Translational Elongation Regulation Of Protein Catabolic Process Positive Regulation Of Translation Positive Regulation Of Metabolic Process Positive Regulation Of Catabolic Process Response To Blue Light Regulation Of Translation Nuclear RNA Surveillance Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) TRNA Surveillance TRAMP-dependent TRNA Surveillance Pathway Nuclear Polyadenylation-dependent RRNA Catabolic Process RNA Surveillance Kinase Binding RNA Catabolic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Monoubiquitinated Protein Deubiquitination Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process RRNA 3'-end Processing Nucleolar Exosome (RNase Complex) Cytosol Regulation Of Translational Elongation TRNA Decay Regulation Of Glycolytic Process Regulation Of Macromolecule Metabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Metabolic Process Regulation Of Proteolysis Double-strand Break Repair Via Nonhomologous End Joining Nucleic Acid Metabolic Process Nucleoplasm Rhythmic Process	Vesicle-mediated Transport Endosome Early Endosome Membrane Early Endosome To Golgi Transport Early Endosome Small GTPase Binding Golgi Vesicle Transport Cellular Response To Amyloid-beta Response To Amyloid-beta Innate Immune Response Response To Mechanical Stimulus Positive Regulation Of CAMP/PKA Signal Transduction Golgi-associated Vesicle Defense Response To Symbiont Defense Response To Gram-negative Bacterium Protein Transport Endosomal Vesicle Fusion Cellular Localization Defense Response To Other Organism Retrograde Transport, Endosome To Golgi Platelet Alpha Granule Post-Golgi Vesicle-mediated Transport Neuronal Dense Core Vesicle Defense Response To Bacterium Lysosomal Transport Establishment Of Protein Localization Cytosolic Transport Recycling Endosome Amyloid Fibril Formation Ionotropic Glutamate Receptor Signaling Pathway Positive Regulation Of Excitatory Postsynaptic Potential Regulation Of Systemic Arterial Blood Pressure By Norepinephrine-epinephrine Ligand-gated Ion Channel Signaling Pathway Vacuolar Transport Negative Regulation Of Cell Communication Positive Regulation Of Mini Excitatory Postsynaptic Potential Negative Regulation Of Signaling Amyloid-beta Complex Regulation Of Extrinsic Apoptotic Signaling Pathway Growth Cone Lamellipodium Positive Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Response To Bacterium Positive Regulation Of Nitric Oxide Metabolic Process Negative Regulation Of Blood Coagulation, Common Pathway Membrane Organization Regulation Of Plasma Membrane Raft Polarization Phosphatidylinositol 3-kinase Catalytic Subunit Binding
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