SETMAR and H3-5

Number of citations of the paper that reports this interaction (PubMedID 23455924)
0

Data Source:
BioGRID (two hybrid)

		SETMAR	H3-5
Description		SET and mariner transposase domain methyltransferase	H3.5 histone
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GO Annotations	Cellular Component	Condensed Chromosome Nucleus Chromosome Nucleolus Site Of Double-strand Break	Nucleosome Euchromatin Nucleus Nucleoplasm Chromosome
	Molecular Function	Single-stranded DNA Endodeoxyribonuclease Activity Nucleic Acid Binding DNA Binding Double-stranded DNA Binding Single-stranded DNA Binding Catalytic Activity Nuclease Activity Endonuclease Activity Protein Binding Methyltransferase Activity Zinc Ion Binding Protein-lysine N-methyltransferase Activity Transferase Activity Hydrolase Activity Histone Methyltransferase Activity Histone H3K4 Methyltransferase Activity Protein Homodimerization Activity DNA Topoisomerase Binding Metal Ion Binding Histone H3K36 Methyltransferase Activity Histone H3 Methyltransferase Activity Histone H3K36 Dimethyltransferase Activity	DNA Binding Protein Binding Structural Constituent Of Chromatin Nucleosomal DNA Binding Protein Heterodimerization Activity
	Biological Process	DNA Double-strand Break Processing DNA Repair Double-strand Break Repair Via Nonhomologous End Joining DNA Catabolic Process Chromatin Organization Chromatin Remodeling DNA Damage Response Cell Population Proliferation DNA Integration Replication Fork Processing Methylation Mitotic DNA Integrity Checkpoint Signaling Nucleic Acid Metabolic Process Positive Regulation Of DNA Topoisomerase (ATP-hydrolyzing) Activity Positive Regulation Of Double-strand Break Repair Via Nonhomologous End Joining Negative Regulation Of Chromosome Organization	Positive Regulation Of Cell Growth
Pathways
Drugs
Diseases
GWAS		Fractures (paediatric) ( 32742401) Midgestational circulating levels of PCBs ( 28235828) Periodontitis (DPAL) ( 24024966) Refractive error ( 32231278) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Spondylosis ( 33332786)
Interacting Genes		4 interacting genes: H3-5 PRPF19 VPS26C XRN2	15 interacting genes: DAXX DNAJC9 FBLIM1 KAT6A KDM1A KDM4B NASP NSD3 PRMT5 PRMT6 PRMT7 SETMAR SMYD1 SMYD3 SUV39H1
Entrez ID		6419	440093
HPRD ID		10225	18443
Ensembl ID		ENSG00000170364	ENSG00000188375
Uniprot IDs		B4DND2 Q53H47 Q96H41	Q6NXT2
PDB IDs		3BO5 3F2K 3K9J 3K9K 7S03	2PUY 3KV4 4Z5T 5BWN 5BWO 5F6K 5I3L 6OI3 7TRL 7W67 7W6I 7W6J 7W6L 7Y0I 7ZEZ 8Q1G 8Q1H 8Q1J 8RBX 8SR6 8T4F 8T4R 8ZXC 9C0O 9DZN
Enriched GO Terms of Interacting Partners?			Chromatin Remodeling Chromatin Organization Histone Methyltransferase Activity Methyltransferase Activity Methylation Histone H3 Methyltransferase Activity Histone H4R3 Methyltransferase Activity Nucleosome Assembly Protein-arginine N-methyltransferase Activity Nucleosome Organization Histone Binding Histone H3K4 Methyltransferase Activity Protein-DNA Complex Assembly Histone Arginine N-methyltransferase Activity Protein-arginine Omega-N Symmetric Methyltransferase Activity Transferase Activity Regulation Of Signal Transduction By P53 Class Mediator Histone H3K36 Dimethyltransferase Activity Nucleoplasm Peptidyl-arginine Methylation Protein-arginine Omega-N Monomethyltransferase Activity Nucleus Chromosome Histone H4 Methyltransferase Activity Transcription Corepressor Activity Histone H3K4 Trimethyltransferase Activity Regulation Of Nucleobase-containing Compound Metabolic Process P53 Binding Histone H3K36 Methyltransferase Activity Histone H3K9 Demethylase Activity Protein-containing Complex Assembly Regulation Of DNA-templated Transcription Negative Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Epigenetic Regulation Of Gene Expression Negative Regulation Of RNA Metabolic Process Protein-containing Complex Organization Regulation Of RNA Metabolic Process Positive Regulation Of ATP-dependent Activity Histone Demethylase Activity Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Chromatin Nuclear Androgen Receptor Binding Histone Methyltransferase Complex S-adenosylmethionine-dependent Methyltransferase Activity Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of ATP-dependent Activity
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