ASXL1 and FOXK1

Number of citations of the paper that reports this interaction (PubMedID 32669118)
72

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology)

		ASXL1	FOXK1
Description		ASXL transcriptional regulator 1	forkhead box K1
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm PR-DUB Complex	Chromatin Nucleus Nucleoplasm Cytoplasm
	Molecular Function	DNA Binding Chromatin Binding Transcription Coactivator Activity Protein Binding Zinc Ion Binding Nuclear Retinoic Acid Receptor Binding Peroxisome Proliferator Activated Receptor Binding Metal Ion Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding 14-3-3 Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Cell Morphogenesis Heart Morphogenesis Chromatin Organization Regulation Of DNA-templated Transcription Animal Organ Morphogenesis Hemopoiesis Response To Retinoic Acid Negative Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Regulation Of Kidney Size Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Retinoic Acid Receptor Signaling Pathway Hematopoietic Or Lymphoid Organ Development Thymus Development Bone Marrow Development Homeostasis Of Number Of Cells Bone Development Lung Saccule Development Podocyte Development	Negative Regulation Of Transcription By RNA Polymerase II Intracellular Glucose Homeostasis Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Muscle Organ Development Negative Regulation Of Autophagy Regulation Of Glucose Metabolic Process Cell Differentiation Response To Starvation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Canonical Glycolysis
Pathways		UCH proteinases	UCH proteinases
Drugs
Diseases		C syndrome, including: Opitz trigonocephaly syndrome; Bohring-Opitz syndrome (BOPS)
GWAS		Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Inflammatory bowel disease ( 28067908) Red cell distribution width ( 32888494)	Apolipoprotein A1 levels ( 32203549) Cognitive decline rate in late mild cognitive impairment ( 26252872) Diastolic blood pressure ( 30224653) Disease progression in age-related macular degeneration ( 29346644) Emotional lability in attention deficit hyperactivity disorder ( 31085060) Heel bone mineral density ( 30598549) Itch intensity from mosquito bite ( 28199695) Mosquito bite size ( 28199695)
Interacting Genes		17 interacting genes: APP BAP1 BRD4 DEFB115 DEFB116 FASN FOXK1 GOLGA6L9 ID1 IRAG1 MRPS7 NCOA6 POLD1 SRM SRPK1 STAT3 UBC	6 interacting genes: ASXL1 CEBPA IRF2 PTEN SRF WEE2-AS1
Entrez ID		171023	221937
HPRD ID		16516	18750
Ensembl ID		ENSG00000171456	ENSG00000164916
Uniprot IDs		A0A2R8Y5U1 Q498B9 Q8IXJ9	P85037
PDB IDs		8H1T 8SVF	8BZM
Enriched GO Terms of Interacting Partners?		Neutrophil Differentiation Amyloid-beta Complex Growth Cone Lamellipodium Enzyme Binding Regulation Of Response To Calcium Ion Response To Stress Amylin Binding Positive Regulation Of ATP Metabolic Process Positive Regulation Of Toll Signaling Pathway Regulation Of Inflammatory Response Chromatin Binding Granulocyte Differentiation Fatty Acid Synthase Activity [acyl-carrier-protein] S-acetyltransferase Activity [acyl-carrier-protein] S-malonyltransferase Activity (3R)-hydroxyacyl-[acyl-carrier-protein] Dehydratase Activity Fatty Acyl-[ACP] Hydrolase Activity Phosphopantetheine Binding Spermidine Synthase Activity Nucleate Erythrocyte Differentiation Thrombocyte Differentiation Histone H4K8ac Reader Activity	Positive Regulation Of Transcription By RNA Polymerase II Learning Or Memory Positive Regulation Of RNA Biosynthetic Process Gland Development Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Cognition Positive Regulation Of Nucleobase-containing Compound Metabolic Process Thymus Development Chromatin Binding Chromatin DNA Binding Positive Regulation Of DNA-templated Transcription Initiation Regulation Of DNA-templated Transcription Initiation RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of Macromolecule Biosynthetic Process Multicellular Organismal-level Homeostasis Negative Regulation Of Synaptic Vesicle Clustering Serum Response Element Binding Positive Regulation Of Biosynthetic Process Hematopoietic Or Lymphoid Organ Development Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Animal Organ Development Response To Vitamin B2 C/EBP Complex Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity Bronchus Cartilage Development Lung Smooth Muscle Development Memory Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of Osteoblast Differentiation Regulation Of Fat Cell Differentiation CHOP-C/EBP Complex Histone Deacetylase Binding Regulation Of RNA Biosynthetic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process DNA-binding Transcription Factor Activity Response To Nutrient Regulation Of Cell Differentiation Regulation Of Axonogenesis Central Nervous System Myelin Maintenance Rhythmic Synaptic Transmission Negative Regulation Of Cell Differentiation Negative Regulation Of Cell Population Proliferation White Fat Cell Proliferation
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