ASXL1 and FASN

Number of citations of the paper that reports this interaction (PubMedID 36180891)
47

Data Source:
BioGRID (affinity chromatography technology)

		ASXL1	FASN
Description		ASXL transcriptional regulator 1	fatty acid synthase
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GO Annotations	Cellular Component	Nucleus Nucleoplasm PR-DUB Complex	Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Membrane Melanosome Glycogen Granule Extracellular Exosome
	Molecular Function	DNA Binding Chromatin Binding Transcription Coactivator Activity Protein Binding Zinc Ion Binding Nuclear Retinoic Acid Receptor Binding Peroxisome Proliferator Activated Receptor Binding Metal Ion Binding	RNA Binding Catalytic Activity Fatty Acid Synthase Activity [acyl-carrier-protein] S-acetyltransferase Activity [acyl-carrier-protein] S-malonyltransferase Activity 3-oxoacyl-[acyl-carrier-protein] Synthase Activity 3-oxoacyl-[acyl-carrier-protein] Reductase (NADPH) Activity Protein Binding Fatty Acyl-[ACP] Hydrolase Activity Oxidoreductase Activity Transferase Activity Acyltransferase Activity Hydrolase Activity Lyase Activity (3R)-hydroxyacyl-[acyl-carrier-protein] Dehydratase Activity Phosphopantetheine Binding Identical Protein Binding Cadherin Binding Enoyl-[acyl-carrier-protein] Reductase (NADPH) Activity
	Biological Process	Cell Morphogenesis Heart Morphogenesis Chromatin Organization Regulation Of DNA-templated Transcription Animal Organ Morphogenesis Hemopoiesis Response To Retinoic Acid Negative Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Regulation Of Kidney Size Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Retinoic Acid Receptor Signaling Pathway Hematopoietic Or Lymphoid Organ Development Thymus Development Bone Marrow Development Homeostasis Of Number Of Cells Bone Development Lung Saccule Development Podocyte Development	Osteoblast Differentiation Epithelial Cell Development Acetyl-CoA Metabolic Process Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Inflammatory Response Response To Nutrient Lipid Biosynthetic Process Ether Lipid Biosynthetic Process Tissue Development Neutrophil Differentiation Monocyte Differentiation Mammary Gland Development Response To Nutrient Levels Host-mediated Perturbation Of Viral Process Fatty-acyl-CoA Biosynthetic Process Response To Caloric Restriction Cellular Response To Interleukin-4 Establishment Of Endothelial Intestinal Barrier
Pathways		UCH proteinases	ChREBP activates metabolic gene expression Vitamin B5 (pantothenate) metabolism Activation of gene expression by SREBF (SREBP) Fatty acyl-CoA biosynthesis Fatty acyl-CoA biosynthesis NR1H2 & NR1H3 regulate gene expression linked to lipogenesis
Drugs			Cerulenin Orlistat
Diseases		C syndrome, including: Opitz trigonocephaly syndrome; Bohring-Opitz syndrome (BOPS)
GWAS		Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Inflammatory bowel disease ( 28067908) Red cell distribution width ( 32888494)	Blood protein levels ( 30072576) Major depressive disorder ( 27777418) Malate levels ( 31560688) Refractive error ( 32231278)
Interacting Genes		17 interacting genes: APP BAP1 BRD4 DEFB115 DEFB116 FASN FOXK1 GOLGA6L9 ID1 IRAG1 MRPS7 NCOA6 POLD1 SRM SRPK1 STAT3 UBC	18 interacting genes: ADIPOQ AKT1 ASXL1 BIRC5 CEBPA CRYAA DUX4 EWSR1 HSP90AA1 LNX1 MTDH NDRG1 PRR12 PTEN RPF1 SNX8 SUMO2 YWHAQ
Entrez ID		171023	2194
HPRD ID		16516	02567
Ensembl ID		ENSG00000171456	ENSG00000169710
Uniprot IDs		A0A2R8Y5U1 Q498B9 Q8IXJ9	P49327
PDB IDs		8H1T 8SVF	1XKT 2CG5 2JFD 2JFK 2PX6 3HHD 3TJM 4PIV 4W82 4W9N 4Z49 5C37 6NNA 7MHD 7MHE 8EYI 8EYK 8G7X 8GKC 8VF7 8VG4 8VLE 8VLO 8VLP 8VM0 8VM5 8VM6 8VM7 8VMC 8VMD 9B7Z 9B80 9MJ9
Enriched GO Terms of Interacting Partners?		Neutrophil Differentiation Amyloid-beta Complex Growth Cone Lamellipodium Enzyme Binding Regulation Of Response To Calcium Ion Response To Stress Amylin Binding Positive Regulation Of ATP Metabolic Process Positive Regulation Of Toll Signaling Pathway Regulation Of Inflammatory Response Chromatin Binding Granulocyte Differentiation Fatty Acid Synthase Activity [acyl-carrier-protein] S-acetyltransferase Activity [acyl-carrier-protein] S-malonyltransferase Activity (3R)-hydroxyacyl-[acyl-carrier-protein] Dehydratase Activity Fatty Acyl-[ACP] Hydrolase Activity Phosphopantetheine Binding Spermidine Synthase Activity Nucleate Erythrocyte Differentiation Thrombocyte Differentiation Histone H4K8ac Reader Activity	Identical Protein Binding Myelin Maintenance Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Protein-containing Complex Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Fat Cell Differentiation Positive Regulation Of Catabolic Process Nitric-oxide Synthase Regulator Activity Regulation Of Ubiquitin-dependent Protein Catabolic Process Peripheral Nervous System Myelin Maintenance Positive Regulation Of Proteolysis Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Protein Catabolic Process Negative Regulation Of Transport Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Response To UV-A Nucleus Regulation Of Gene Expression Response To Heat Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Protein Metabolic Process Synapse Maturation Regulation Of RNA Metabolic Process Apoptotic Process Positive Regulation Of Proteasomal Protein Catabolic Process Plasma Membrane Organization Response To Decreased Oxygen Levels Programmed Cell Death Response To Tumor Necrosis Factor Cell Death Response To Oxygen Levels Protein Refolding Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Peptidyl-serine Phosphorylation Reactive Nitrogen Species Metabolic Process Response To Temperature Stimulus Regulation Of Macromolecule Metabolic Process Regulation Of Smooth Muscle Cell Proliferation 14-3-3 Protein Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nitric Oxide Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Cell Cycle Brown Fat Cell Differentiation Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Regulation Of Protein Catabolic Process Regulation Of Proteolysis Protein Homodimerization Activity
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