ASXL1 and DEFB115

		ASXL1	DEFB115
Description		ASXL transcriptional regulator 1	defensin beta 115
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm PR-DUB Complex	Extracellular Region
	Molecular Function	DNA Binding Chromatin Binding Transcription Coactivator Activity Protein Binding Zinc Ion Binding Nuclear Retinoic Acid Receptor Binding Peroxisome Proliferator Activated Receptor Binding Metal Ion Binding	Protein Binding
	Biological Process	Cell Morphogenesis Heart Morphogenesis Chromatin Organization Regulation Of DNA-templated Transcription Animal Organ Morphogenesis Hemopoiesis Response To Retinoic Acid Negative Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Regulation Of Kidney Size Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Retinoic Acid Receptor Signaling Pathway Hematopoietic Or Lymphoid Organ Development Thymus Development Bone Marrow Development Homeostasis Of Number Of Cells Bone Development Lung Saccule Development Podocyte Development	Defense Response Defense Response To Bacterium Innate Immune Response Defense Response To Gram-negative Bacterium
Pathways		UCH proteinases	Beta defensins Defensins
Drugs
Diseases		C syndrome, including: Opitz trigonocephaly syndrome; Bohring-Opitz syndrome (BOPS)
GWAS		Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Inflammatory bowel disease ( 28067908) Red cell distribution width ( 32888494)	Prudent dietary pattern ( 28644415)
Interacting Genes		17 interacting genes: APP BAP1 BRD4 DEFB115 DEFB116 FASN FOXK1 GOLGA6L9 ID1 IRAG1 MRPS7 NCOA6 POLD1 SRM SRPK1 STAT3 UBC	4 interacting genes: ASXL1 POFUT1 UBQLN1 UBQLN2
Entrez ID		171023	245929
HPRD ID		16516	18944
Ensembl ID		ENSG00000171456	ENSG00000215547
Uniprot IDs		A0A2R8Y5U1 Q498B9 Q8IXJ9	Q30KQ5
PDB IDs		8H1T 8SVF
Enriched GO Terms of Interacting Partners?		Neutrophil Differentiation Amyloid-beta Complex Growth Cone Lamellipodium Enzyme Binding Regulation Of Response To Calcium Ion Response To Stress Amylin Binding Positive Regulation Of ATP Metabolic Process Positive Regulation Of Toll Signaling Pathway Regulation Of Inflammatory Response Chromatin Binding Granulocyte Differentiation Fatty Acid Synthase Activity [acyl-carrier-protein] S-acetyltransferase Activity [acyl-carrier-protein] S-malonyltransferase Activity (3R)-hydroxyacyl-[acyl-carrier-protein] Dehydratase Activity Fatty Acyl-[ACP] Hydrolase Activity Phosphopantetheine Binding Spermidine Synthase Activity Nucleate Erythrocyte Differentiation Thrombocyte Differentiation Histone H4K8ac Reader Activity	Positive Regulation Of ERAD Pathway Regulation Of ERAD Pathway Polyubiquitin Modification-dependent Protein Binding Positive Regulation Of Response To Endoplasmic Reticulum Stress Autophagosome Regulation Of Response To Endoplasmic Reticulum Stress Autophagosome Assembly ERAD Pathway Autophagosome Organization Negative Regulation Of Store-operated Calcium Channel Activity Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Negative Regulation Of G Protein-coupled Receptor Internalization Regulation Of Signal Transduction Protein O-linked Glycosylation Via Fucose Peptide-O-fucosyltransferase Activity Positive Regulation Of Proteolysis Vacuole Organization Response To Endoplasmic Reticulum Stress Negative Regulation Of Clathrin-dependent Endocytosis Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Regulation Of Macroautophagy Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Retinoic Acid Receptor Signaling Pathway PR-DUB Complex Lung Saccule Development Regulation Of Kidney Size Regulation Of Cell Communication Regulation Of Signaling Bone Marrow Development Negative Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Autophagy Peroxisome Proliferator Activated Receptor Binding Regulation Of Protein Catabolic Process Regulation Of Proteolysis Regulation Of Autophagy Regulation Of Toll-like Receptor 3 Signaling Pathway Podocyte Development Fucose Metabolic Process Aggrephagy Regulation Of Retinoic Acid Receptor Signaling Pathway Negative Regulation Of Transport Negative Regulation Of Receptor Internalization Nuclear Retinoic Acid Receptor Binding Regulation Of Clathrin-dependent Endocytosis Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Proteasomal Protein Catabolic Process Regulation Of Cellular Response To Stress Positive Regulation Of Catabolic Process
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