ASXL1 and DEFB116

		ASXL1	DEFB116
Description		ASXL transcriptional regulator 1	defensin beta 116
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm PR-DUB Complex	Extracellular Region
	Molecular Function	DNA Binding Chromatin Binding Transcription Coactivator Activity Protein Binding Zinc Ion Binding Nuclear Retinoic Acid Receptor Binding Peroxisome Proliferator Activated Receptor Binding Metal Ion Binding
	Biological Process	Cell Morphogenesis Heart Morphogenesis Chromatin Organization Regulation Of DNA-templated Transcription Animal Organ Morphogenesis Hemopoiesis Response To Retinoic Acid Negative Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Regulation Of Kidney Size Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Retinoic Acid Receptor Signaling Pathway Hematopoietic Or Lymphoid Organ Development Thymus Development Bone Marrow Development Homeostasis Of Number Of Cells Bone Development Lung Saccule Development Podocyte Development	Defense Response Defense Response To Bacterium Innate Immune Response
Pathways		UCH proteinases	Beta defensins Defensins
Drugs
Diseases		C syndrome, including: Opitz trigonocephaly syndrome; Bohring-Opitz syndrome (BOPS)
GWAS		Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Inflammatory bowel disease ( 28067908) Red cell distribution width ( 32888494)	Prudent dietary pattern ( 28644415) Smoking initiation (ever regular vs never regular) ( 30679032) Smoking status (ever vs never smokers) ( 30643258)
Interacting Genes		17 interacting genes: APP BAP1 BRD4 DEFB115 DEFB116 FASN FOXK1 GOLGA6L9 ID1 IRAG1 MRPS7 NCOA6 POLD1 SRM SRPK1 STAT3 UBC	2 interacting genes: ASXL1 POFUT1
Entrez ID		171023	245930
HPRD ID		16516	19020
Ensembl ID		ENSG00000171456	ENSG00000215545
Uniprot IDs		A0A2R8Y5U1 Q498B9 Q8IXJ9	Q30KQ4
PDB IDs		8H1T 8SVF
Enriched GO Terms of Interacting Partners?		Neutrophil Differentiation Amyloid-beta Complex Growth Cone Lamellipodium Enzyme Binding Regulation Of Response To Calcium Ion Response To Stress Amylin Binding Positive Regulation Of ATP Metabolic Process Positive Regulation Of Toll Signaling Pathway Regulation Of Inflammatory Response Chromatin Binding Granulocyte Differentiation Fatty Acid Synthase Activity [acyl-carrier-protein] S-acetyltransferase Activity [acyl-carrier-protein] S-malonyltransferase Activity (3R)-hydroxyacyl-[acyl-carrier-protein] Dehydratase Activity Fatty Acyl-[ACP] Hydrolase Activity Phosphopantetheine Binding Spermidine Synthase Activity Nucleate Erythrocyte Differentiation Thrombocyte Differentiation Histone H4K8ac Reader Activity	Protein O-linked Glycosylation Via Fucose Peptide-O-fucosyltransferase Activity Positive Regulation Of Retinoic Acid Receptor Signaling Pathway PR-DUB Complex Lung Saccule Development Bone Marrow Development Regulation Of Kidney Size Negative Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Fucose Metabolic Process Regulation Of Retinoic Acid Receptor Signaling Pathway Peroxisome Proliferator Activated Receptor Binding Podocyte Development Nuclear Retinoic Acid Receptor Binding Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Segmentation Animal Organ Development Somitogenesis Negative Regulation Of Fat Cell Differentiation Heart Morphogenesis Thymus Development
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