ASXL1 and IRAG1

		ASXL1	IRAG1
Description		ASXL transcriptional regulator 1	inositol 1,4,5-triphosphate receptor associated 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm PR-DUB Complex	Cytoplasm Endoplasmic Reticulum Membrane Membrane Sarcoplasmic Reticulum Platelet Dense Tubular Network Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	DNA Binding Chromatin Binding Transcription Coactivator Activity Protein Binding Zinc Ion Binding Nuclear Retinoic Acid Receptor Binding Peroxisome Proliferator Activated Receptor Binding Metal Ion Binding	Protein Binding
	Biological Process	Cell Morphogenesis Heart Morphogenesis Chromatin Organization Regulation Of DNA-templated Transcription Animal Organ Morphogenesis Hemopoiesis Response To Retinoic Acid Negative Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Regulation Of Kidney Size Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Retinoic Acid Receptor Signaling Pathway Hematopoietic Or Lymphoid Organ Development Thymus Development Bone Marrow Development Homeostasis Of Number Of Cells Bone Development Lung Saccule Development Podocyte Development	CGMP-mediated Signaling Negative Regulation Of Smooth Muscle Contraction Relaxation Of Vascular Associated Smooth Muscle
Pathways		UCH proteinases	cGMP effects
Drugs
Diseases		C syndrome, including: Opitz trigonocephaly syndrome; Bohring-Opitz syndrome (BOPS)
GWAS		Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Inflammatory bowel disease ( 28067908) Red cell distribution width ( 32888494)
Interacting Genes		17 interacting genes: APP BAP1 BRD4 DEFB115 DEFB116 FASN FOXK1 GOLGA6L9 ID1 IRAG1 MRPS7 NCOA6 POLD1 SRM SRPK1 STAT3 UBC	3 interacting genes: ASXL1 ITPR1 PRKG1
Entrez ID		171023	10335
HPRD ID		16516	05242
Ensembl ID		ENSG00000171456	ENSG00000072952
Uniprot IDs		A0A2R8Y5U1 Q498B9 Q8IXJ9	Q9Y6F6
PDB IDs		8H1T 8SVF
Enriched GO Terms of Interacting Partners?		Neutrophil Differentiation Amyloid-beta Complex Growth Cone Lamellipodium Enzyme Binding Regulation Of Response To Calcium Ion Response To Stress Amylin Binding Positive Regulation Of ATP Metabolic Process Positive Regulation Of Toll Signaling Pathway Regulation Of Inflammatory Response Chromatin Binding Granulocyte Differentiation Fatty Acid Synthase Activity [acyl-carrier-protein] S-acetyltransferase Activity [acyl-carrier-protein] S-malonyltransferase Activity (3R)-hydroxyacyl-[acyl-carrier-protein] Dehydratase Activity Fatty Acyl-[ACP] Hydrolase Activity Phosphopantetheine Binding Spermidine Synthase Activity Nucleate Erythrocyte Differentiation Thrombocyte Differentiation Histone H4K8ac Reader Activity	Intracellularly Gated Calcium Channel Activity Platelet Dense Tubular Network Inositol 1,4,5-trisphosphate-gated Calcium Channel Activity Musculoskeletal Movement Inositol 1,4,5-trisphosphate Receptor Activity Involved In Regulation Of Postsynaptic Cytosolic Calcium Levels Release Of Sequestered Calcium Ion Into Cytosol By Endoplasmic Reticulum Epithelial Fluid Transport Platelet Dense Granule Membrane Calcium Ion Transmembrane Transporter Activity Platelet Dense Tubular Network Membrane Calcium Import Into The Mitochondrion Calcineurin Complex Voluntary Musculoskeletal Movement Phospholipase C-activating G Protein-coupled Acetylcholine Receptor Signaling Pathway Calcium Channel Inhibitor Activity Cell Morphogenesis Regulation Of Postsynaptic Cytosolic Calcium Ion Concentration Inositol 1,4,5 Trisphosphate Binding Negative Regulation Of Amino Acid Transport CGMP-dependent Protein Kinase Activity Mitogen-activated Protein Kinase P38 Binding Negative Regulation Of Inositol Phosphate Biosynthetic Process Cell Growth Involved In Cardiac Muscle Cell Development Regulation Of Testosterone Biosynthetic Process Relaxation Of Smooth Muscle Negative Regulation Of Glutamate Secretion Relaxation Of Vascular Associated Smooth Muscle Negative Regulation Of Homotypic Cell-cell Adhesion Negative Regulation Of Smooth Muscle Contraction Negative Regulation Of Platelet Aggregation Positive Regulation Of Retinoic Acid Receptor Signaling Pathway Regulation Of Retinoic Acid Receptor Signaling Pathway Peroxisome Proliferator Activated Receptor Binding Podocyte Development PR-DUB Complex Lung Saccule Development Bone Marrow Development Regulation Of Kidney Size Negative Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway CGMP Binding G Protein-coupled Acetylcholine Receptor Signaling Pathway Mitochondrial Calcium Ion Transmembrane Transport Negative Regulation Of Calcium-mediated Signaling Regulation Of Biological Quality Regulation Of Secretion By Cell Positive Regulation Of Circadian Rhythm Relaxation Of Muscle Collateral Sprouting Negative Regulation Of Muscle Contraction Negative Regulation Of Vascular Associated Smooth Muscle Cell Migration
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