FOXK1 and IRF2

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down)

		FOXK1	IRF2
Description		forkhead box K1	interferon regulatory factor 2
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm	Chromatin Nucleus Nucleoplasm Cytosol Focal Adhesion
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding 14-3-3 Protein Binding Sequence-specific Double-stranded DNA Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Intracellular Glucose Homeostasis Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Muscle Organ Development Negative Regulation Of Autophagy Regulation Of Glucose Metabolic Process Cell Differentiation Response To Starvation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Canonical Glycolysis	Negative Regulation Of Transcription By RNA Polymerase II Immune System Process Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Cell Population Proliferation Positive Regulation Of Transcription By RNA Polymerase II Defense Response To Virus
Pathways		UCH proteinases	Pyroptosis Interferon gamma signaling Interferon alpha/beta signaling Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Cognitive decline rate in late mild cognitive impairment ( 26252872) Diastolic blood pressure ( 30224653) Disease progression in age-related macular degeneration ( 29346644) Emotional lability in attention deficit hyperactivity disorder ( 31085060) Heel bone mineral density ( 30598549) Itch intensity from mosquito bite ( 28199695) Mosquito bite size ( 28199695)	Acute kidney injury in critical illness ( 27576016) Adverse response to drug ( 30420678) Chronic lymphocytic leukemia ( 28165464) Hippocampal volume in Alzheimer's disease dementia ( 29274321) Lewy body disease ( 25188341) Night sleep phenotypes ( 27126917) Nonsyndromic cleft lip ( 31609978) Type 1 diabetes ( 34012112)
Interacting Genes		6 interacting genes: ASXL1 CEBPA IRF2 PTEN SRF WEE2-AS1	24 interacting genes: APP ATG7 BRD7 CSNK2A1 EP300 FKBP7 FOXK1 HMGB1 HMGN1 IRF2BP1 IRF2BP2 IRF8 KAT2A KAT2B MDM2 NFE2L2 NFKB1 PPP3CB PRKACA RELA SPI1 STAT1 TRIM55 TRIM63
Entrez ID		221937	3660
HPRD ID		18750	00962
Ensembl ID		ENSG00000164916	ENSG00000168310
Uniprot IDs		P85037	P14316
PDB IDs		8BZM	8YTG
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Transcription By RNA Polymerase II Learning Or Memory Positive Regulation Of RNA Biosynthetic Process Gland Development Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Cognition Positive Regulation Of Nucleobase-containing Compound Metabolic Process Thymus Development Chromatin Binding Chromatin DNA Binding Positive Regulation Of DNA-templated Transcription Initiation Regulation Of DNA-templated Transcription Initiation RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of Macromolecule Biosynthetic Process Multicellular Organismal-level Homeostasis Negative Regulation Of Synaptic Vesicle Clustering Serum Response Element Binding Positive Regulation Of Biosynthetic Process Hematopoietic Or Lymphoid Organ Development Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Animal Organ Development Response To Vitamin B2 C/EBP Complex Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity Bronchus Cartilage Development Lung Smooth Muscle Development Memory Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of Osteoblast Differentiation Regulation Of Fat Cell Differentiation CHOP-C/EBP Complex Histone Deacetylase Binding Regulation Of RNA Biosynthetic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process DNA-binding Transcription Factor Activity Response To Nutrient Regulation Of Cell Differentiation Regulation Of Axonogenesis Central Nervous System Myelin Maintenance Rhythmic Synaptic Transmission Negative Regulation Of Cell Differentiation Negative Regulation Of Cell Population Proliferation White Fat Cell Proliferation	Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of DNA-templated Transcription Response To Stress Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Metabolic Process Positive Regulation Of RNA Biosynthetic Process Regulation Of Carbohydrate Catabolic Process Regulation Of Small Molecule Metabolic Process Positive Regulation Of DNA-templated Transcription Response To Nutrient Levels Cellular Response To Oxygen-containing Compound Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Metabolic Process Response To Cytokine Transcription Cis-regulatory Region Binding Response To Peptide Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Cellular Response To Peptide Hormone Stimulus Regulation Of Glucose Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Response To Hormone Defense Response Nucleoplasm Positive Regulation Of Gene Expression, Epigenetic Regulation Of Glycolytic Process Regulation Of Metabolic Process Negative Regulation Of Small Molecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Positive Regulation Of Gene Expression Regulation Of Cellular Response To Stress Regulation Of Generation Of Precursor Metabolites And Energy Regulation Of Macromolecule Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Macromolecule Biosynthetic Process Regulation Of ATP Metabolic Process Regulation Of Purine Nucleotide Metabolic Process
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